• Childhood cancer survival in Europe 1999-2007: results of EUROCARE-5--a population-based study.

      Gatta, Gemma; Botta, Laura; Rossi, Silvia; Aareleid, Tiiu; Bielska-Lasota, Magdalena; Clavel, Jacqueline; Dimitrova, Nadya; Jakab, Zsuzsanna; Kaatsch, Peter; Lacour, Brigitte; et al. (Elsevier Science Inc, 2014-01)
      Survival and cure rates for childhood cancers in Europe have greatly improved over the past 40 years and are mostly good, although not in all European countries. The EUROCARE-5 survival study estimates survival of children diagnosed with cancer between 2000 and 2007, assesses whether survival differences among European countries have changed, and investigates changes from 1999 to 2007.
    • Metabolomic analysis of platelets during storage: a comparison between apheresis- and buffy coat-derived platelet concentrates.

      Paglia, Giuseppe; Sigurjónsson, Ólafur E; Rolfsson, Óttar; Hansen, Morten Bagge; Brynjólfsson, Sigurður; Gudmundsson, Sveinn; Palsson, Bernhard O; [ 1 ] Univ Iceland, Ctr Syst Biol, Reykjavik, Iceland [ 2 ] Landspitali Univ Hosp, Blood Bank, IS-105 Reykjavik, Iceland [ 3 ] Reykjavik Univ, Sch Sci & Engn, Reykjavik, Iceland [ 4 ] Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark (Wiley-Blackwell, 2015-02)
      Platelet concentrates (PCs) can be prepared using three methods: platelet (PLT)-rich plasma, apheresis, and buffy coat. The aim of this study was to obtain a comprehensive data set that describes metabolism of buffy coat-derived PLTs during storage and to compare it with a previously published parallel data set obtained for apheresis-derived PLTs.
    • Systems biology of stored blood cells: can it help to extend the expiration date?

      Paglia, Giuseppe; Palsson, Bernhard Ø; Sigurjonsson, Olafur E; Center for Systems Biology, University of Iceland (Elsevier Science B.V., 2012)
      With increasingly stringent regulations regarding deferral and elimination of blood donors it will become increasingly important to extend the expiration date of blood components beyond the current allowed storage periods. One reason for the storage time limit for blood components is that platelets and red blood cells develop a condition called storage lesions during their storage in plastic blood containers. Systems biology provides comprehensive bio-chemical descriptions of organisms through quantitative measurements and data integration in mathematical models. The biological knowledge for a target organism can be translated in a mathematical format and used to compute physiological properties. The use of systems biology represents a concrete solution in the study of blood cell storage lesions, and it may open up new avenues towards developing better storage methods and better storage media, thereby extending the storage period of blood components. This article is part of a Special Issue entitled: Integrated omics.