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Systems biology of stored blood cells: can it help to extend the expiration date?

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Authors
Paglia, Giuseppe
Palsson, Bernhard Ø
Sigurjonsson, Olafur E
Issue Date
2012

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J Proteomics 2012, 76 Spec No.:163-7
Abstract
With increasingly stringent regulations regarding deferral and elimination of blood donors it will become increasingly important to extend the expiration date of blood components beyond the current allowed storage periods. One reason for the storage time limit for blood components is that platelets and red blood cells develop a condition called storage lesions during their storage in plastic blood containers. Systems biology provides comprehensive bio-chemical descriptions of organisms through quantitative measurements and data integration in mathematical models. The biological knowledge for a target organism can be translated in a mathematical format and used to compute physiological properties. The use of systems biology represents a concrete solution in the study of blood cell storage lesions, and it may open up new avenues towards developing better storage methods and better storage media, thereby extending the storage period of blood components. This article is part of a Special Issue entitled: Integrated omics.
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Efst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn
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http://www.sciencedirect.com
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openAccess
ae974a485f413a2113503eed53cd6c53
10.1016/j.jprot.2012.08.014
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