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Clinical symptoms in adults with selective IgA deficiency: a case-control study.

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Authors
Jorgensen, G H
Gardulf, A
Sigurdsson, M I
Sigurdardottir, S Th
Thorsteinsdottir, I
Gudmundsson, S
Hammarström, L
Ludviksson, B R
Issue Date
2013-05

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Citation
J. Clin. Immunol. 2013, 33(4):742-7
Abstract
Selective IgA deficiency (SIgAD) is the most common primary immunodeficiency in Caucasians with a prevalence of 1/600 and is generally considered a mild disorder. In this study, the clinical status of 32 adults with SIgAD was investigated and compared to 63 age- and gender matched controls, randomly selected from a population database. The SIgAD individuals reported significantly more often contracting various upper and lower respiratory infections, with 8 (25.0 %) having been diagnosed with ≥1 pneumonia in the preceding two years, compared to one (1.6 %) control (p < 0.001). Furthermore, the SIgAD individuals were found to have increased proneness to infections and increased prevalence of allergic diseases and autoimmunity, with a total of 84.4 % being affected by any of these diseases, compared to 47.6 % of the controls (p < 0.01). This study challenges the common statement of SIgAD being a mild form of immunodeficiency. It also highlights the importance of using matched controls in PID clinical research to better detect clinically important manifestations.
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http://dx.doi.org/10.1007/s10875-012-9858-x
http://link.springer.com/article/10.1007%2Fs10875-012-9858-x
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Archived with thanks to Journal of clinical immunology
ae974a485f413a2113503eed53cd6c53
10.1007/s10875-012-9858-x
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