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Etiology of Waldenström macroglobulinemia: genetic factors and immune-related conditions.

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Authors
Manasanch, Elisabet E
Kristinsson, Sigurdur Y
Landgren, Ola
Issue Date
2013-04

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Clin Lymphoma Myeloma Leuk 2013, 13(2):194-7
Abstract
Epidemiologic studies provide an insight into the etiology of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia, which indicates that repetitive immune stimulation and genetic factors play an important role. Here, the current understanding on the causes of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia are reviewed. Recent studies of the literature are discussed, and future population-based studies are proposed to further elucidate the molecular mechanisms that underlie these associations. Finally, the clinical implications of these data are outlined, and perspectives on clinical follow-up and counseling are provided.
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http://dx.doi.org/10.1016/j.clml.2013.02.002
http://www.sciencedirect.com/science/article/pii/S2152265013000074
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Archived with thanks to Clinical lymphoma, myeloma & leukemia
ae974a485f413a2113503eed53cd6c53
10.1016/j.clml.2013.02.002
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