Clonal spread of resistant pneumococci despite diminished antimicrobial use
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsArason, Vilhjalmur A
Sigurdsson, Johann A
Kristinsson, Karl G
MetadataShow full item record
CitationMicrob. Drug Resist. 2002, 8(3):187-92
AbstractThe effects of community-wide interventions to reduce resistance rates are poorly understood. This study evaluated the effect of reduced antimicrobial usage on the spread of penicillin-nonsusceptible pneumococci (PNSP) in four communities in Iceland. The study was performed after interventions to reduce antimicrobial usage and compared to an identical study performed 5 years before. A randomized sample of 953 children was chosen from all 2,900 1- to 6-year-old children living in four well-defined communities. The main outcome measures were nasopharyngeal carriage of PNSP and individual and community use of antimicrobials. Pneumococci were carried by 51.7% of the 743 children enrolled, and 8.1% of the pneumococci were PNSP as opposed to 8.5% in the previous study. The antimicrobial use of participants had been reduced from 1.5 to 1.1 courses/year and the overall use among children <7 years old living in the study areas from 13.6 to 11.1 defined daily dosages/1000 children per day. The prevalence of PNSP increased in the two areas furthest away from the capital area despite reduced consumption. The major risk factors for carriage of PNSP remained the same. Interventions can be effective in reducing antimicrobial use. Pandemic multiresistant clones can also spread fast in small communities with low antimicrobial use, where their appearance may be delayed compared to highly populated urban areas. Clonal spread and herd immunity are important factors to be considered in the evaluation of intervention effects.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- The role of antimicrobial use in the epidemiology of resistant pneumococci: A 10-year follow up.
- Authors: Arason VA, Sigurdsson JA, Erlendsdottir H, Gudmundsson S, Kristinsson KG
- Issue date: 2006 Fall
- Do antimicrobials increase the carriage rate of penicillin resistant pneumococci in children? Cross sectional prevalence study.
- Authors: Arason VA, Kristinsson KG, Sigurdsson JA, Stefánsdóttir G, Mölstad S, Gudmundsson S
- Issue date: 1996 Aug 17
- Clonal analysis of Streptococcus pneumoniae nonsusceptible to penicillin at day-care centers with index cases, in a region with low incidence of resistance: emergence of an invasive type 35B clone among carriers.
- Authors: Henriqus Normark B, Christensson B, Sandgren A, Noreen B, Sylvan S, Burman LG, Olsson-Liljequist B
- Issue date: 2003 Winter
- Epidemiology of penicillin-non-susceptible pneumococci in Iceland, 1995-2010.
- Authors: Hjálmarsdóttir MÁ, Kristinsson KG
- Issue date: 2014 Apr
- Frequency of penicillin-resistant pneumococci in children is correlated to community utilization of antibiotics.
- Authors: Melander E, Ekdahl K, Jönsson G, Mölstad S
- Issue date: 2000 Dec