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dc.contributor.authorGunnarsson, Sverrir I
dc.contributor.authorPalsson, Runolfur
dc.contributor.authorSigurdsson, Gunnar
dc.contributor.authorIndridason, Olafur S
dc.date.accessioned2014-03-18T15:40:54Z
dc.date.available2014-03-18T15:40:54Z
dc.date.issued2013
dc.date.submitted2013
dc.identifier.citationNephron Clin Pract. 2013, 123 (1-2):22-7en
dc.identifier.issn1660-2110
dc.identifier.pmid23752061
dc.identifier.doi10.1159/000351130
dc.identifier.urihttp://hdl.handle.net/2336/314222
dc.descriptionTo access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.en
dc.description.abstractDifferences in body composition may lead to imprecision in estimates of glomerular filtration rate (eGFR) derived from serum creatinine. Our aims were to examine the relationship between eGFR and anthropometric and body composition measures and handgrip strength.
dc.description.abstractWe analyzed data from a cross-sectional study comprising 1,630 randomly selected community-dwelling adults. The Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were used to calculate eGFR from IMDS-standardized serum creatinine. Body mass index and body surface area were calculated from measured height and weight. Body composition was determined by dual-energy x-ray absorptiometry, handgrip strength measured by a hand-held dynamometer. Regression analysis was used to examine the association between eGFR and other factors.
dc.description.abstractIn women, eGFR determined by the MDRD equation was inversely associated with height (β = -0.08; p = 0.012), lean mass percentage (β = -0.06; p = 0.047) and handgrip strength (β = -0.15; p < 0.001) and eGFR calculated using the CKD-EPI equation was inversely associated with handgrip strength (β = -0.08; p = 0.001). In men, there was an inverse association between eGFR by the MDRD equation and lean mass percentage (β = -0.10; p = 0.013) and handgrip strength (β = -0.12; p = 0.022) and between eGFR by the CKD-EPI equation and lean mass percentage (β = -0.07; p = 0.018). The R(2) for these variables was <0.02.
dc.description.abstractThe inverse relationship between eGFR and measures of lean mass percentage and handgrip strength suggests that incorporation of these variables might improve eGFR prediction from serum creatinine in the general population. This effect appears to be small however and needs to be examined in studies that include measured GFR.
dc.language.isoenen
dc.publisherKargeren
dc.relation.urlhttp://dx.doi.org/10.1159/000351130en
dc.rightsArchived with thanks to Nephron. Clinical practiceen
dc.subjectMannslíkaminnen
dc.subjectKrafturen
dc.subject.meshAdulten
dc.subject.meshAge Distributionen
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshAlgorithmsen
dc.subject.meshBody Compositionen
dc.subject.meshComputer Simulationen
dc.subject.meshCreatinineen
dc.subject.meshFemaleen
dc.subject.meshGlomerular Filtration Rateen
dc.subject.meshHand Strengthen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshModels, Biologicalen
dc.subject.meshReference Valuesen
dc.subject.meshReproducibility of Resultsen
dc.subject.meshSensitivity and Specificityen
dc.subject.meshSex Distributionen
dc.subject.meshStatistics as Topicen
dc.titleRelationship between body composition and glomerular filtration rate estimates in the general population.en
dc.typeArticleen
dc.contributor.departmentNatl Univ Hosp Iceland, Landspitali, Internal Med Serv, Div Nephrol, IS-101 Reykjavik, Iceland, Natl Univ Hosp Iceland, Landspitali, Internal Med Serv, Div Endocrinol & Metab, IS-101 Reykjavik, Iceland, Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Icelanden
dc.identifier.journalNephron. Clinical practiceen
dc.rights.accessNational Consortium - Landsaðganguren
html.description.abstractDifferences in body composition may lead to imprecision in estimates of glomerular filtration rate (eGFR) derived from serum creatinine. Our aims were to examine the relationship between eGFR and anthropometric and body composition measures and handgrip strength.
html.description.abstractWe analyzed data from a cross-sectional study comprising 1,630 randomly selected community-dwelling adults. The Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were used to calculate eGFR from IMDS-standardized serum creatinine. Body mass index and body surface area were calculated from measured height and weight. Body composition was determined by dual-energy x-ray absorptiometry, handgrip strength measured by a hand-held dynamometer. Regression analysis was used to examine the association between eGFR and other factors.
html.description.abstractIn women, eGFR determined by the MDRD equation was inversely associated with height (β = -0.08; p = 0.012), lean mass percentage (β = -0.06; p = 0.047) and handgrip strength (β = -0.15; p < 0.001) and eGFR calculated using the CKD-EPI equation was inversely associated with handgrip strength (β = -0.08; p = 0.001). In men, there was an inverse association between eGFR by the MDRD equation and lean mass percentage (β = -0.10; p = 0.013) and handgrip strength (β = -0.12; p = 0.022) and between eGFR by the CKD-EPI equation and lean mass percentage (β = -0.07; p = 0.018). The R(2) for these variables was <0.02.
html.description.abstractThe inverse relationship between eGFR and measures of lean mass percentage and handgrip strength suggests that incorporation of these variables might improve eGFR prediction from serum creatinine in the general population. This effect appears to be small however and needs to be examined in studies that include measured GFR.


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