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dc.contributor.authorArnarsson, Arsaell
dc.contributor.authorJonasson, Fridbert
dc.contributor.authorSasaki, Hiroshi
dc.contributor.authorOno, Masaji
dc.contributor.authorJonsson, Vesteinn
dc.contributor.authorKojima, Masami
dc.contributor.authorKatoh, Nobuyo
dc.contributor.authorSasaki, Kazuyuki
dc.date.accessioned2008-07-11T11:21:08Z
dc.date.available2008-07-11T11:21:08Z
dc.date.issued2002
dc.date.submitted2008-07-11
dc.identifier.citationDev Ophthalmol. 2002, 35:12-20en
dc.identifier.issn0250-3751
dc.identifier.pmid12061269
dc.identifier.doi10.1159/000060804
dc.identifier.urihttp://hdl.handle.net/2336/31603
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPURPOSE: The purpose of this study is to examine risk factors for nuclear lens opacification in citizens of Reykjavik. METHODS: 1,045 persons, 583 females and 462 males aged 50 years and older, were randomly sampled and underwent a detailed eye examination and answered a questionnaire. In all Scheimpflug photography of the anterior eye segment was done including the lens as well as retroilluminated photography of the lens. These photographs were used for the diagnosis of lens opacification. The data was analyzed using a logistic regression model. RESULTS: An increased risk for all grades of nuclear opacifications was found with ageing (OR = 1.228, 95% CI = 1.192-1.264, p = 0.000), cigarette smoking for more than 20 pack/years (OR = 2.521, 95% CI = 1.521-4.125, p = 0.000) and pipe or cigar smoking (OR = 2.478, 95% CI = 1.200-5.116, p = 0.014). Outdoor exposure, cortical lens opacification grade II and III and computer usage were not found to be linked to higher risk of nuclear opacification. No correlation was found between nuclear opacification and the consumption of vitamins, herring, sardines and shrimps, cod-liver oil or plant oil, nor were iris color, hyperopia, systemic steroid use, cardiovascular disease, diabetes, glaucoma and pseudoexfoliation found to have a significant effect. CONCLUSIONS: Ageing is a major risk factor for nuclear lens opacification, and smoking is a major modifiable risk factor. Cortical and nuclear lens opacifications do not share the same modifiable risk factors.
dc.language.isoenen
dc.publisherKargeren
dc.relation.urlhttp://dx.doi.org/10.1159/000060804en
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshAgingen
dc.subject.meshCataracten
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshLens Nucleus, Crystallineen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPhotographyen
dc.subject.meshQuestionnairesen
dc.subject.meshRisk Factorsen
dc.subject.meshSmokingen
dc.titleRisk factors for nuclear lens opacification: the Reykjavik Eye Study.en
dc.typeArticleen
dc.contributor.departmentDepartment of Ophthalmology, University Hospital, Reykjavik, Iceland.en
dc.identifier.journalDevelopments in ophthalmologyen
html.description.abstractPURPOSE: The purpose of this study is to examine risk factors for nuclear lens opacification in citizens of Reykjavik. METHODS: 1,045 persons, 583 females and 462 males aged 50 years and older, were randomly sampled and underwent a detailed eye examination and answered a questionnaire. In all Scheimpflug photography of the anterior eye segment was done including the lens as well as retroilluminated photography of the lens. These photographs were used for the diagnosis of lens opacification. The data was analyzed using a logistic regression model. RESULTS: An increased risk for all grades of nuclear opacifications was found with ageing (OR = 1.228, 95% CI = 1.192-1.264, p = 0.000), cigarette smoking for more than 20 pack/years (OR = 2.521, 95% CI = 1.521-4.125, p = 0.000) and pipe or cigar smoking (OR = 2.478, 95% CI = 1.200-5.116, p = 0.014). Outdoor exposure, cortical lens opacification grade II and III and computer usage were not found to be linked to higher risk of nuclear opacification. No correlation was found between nuclear opacification and the consumption of vitamins, herring, sardines and shrimps, cod-liver oil or plant oil, nor were iris color, hyperopia, systemic steroid use, cardiovascular disease, diabetes, glaucoma and pseudoexfoliation found to have a significant effect. CONCLUSIONS: Ageing is a major risk factor for nuclear lens opacification, and smoking is a major modifiable risk factor. Cortical and nuclear lens opacifications do not share the same modifiable risk factors.


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