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GWAS-uncovered SNPs in PLCE1 and RFT2 genes are not implicated in Dutch esophageal adenocarcinoma and squamous cell carcinoma etiology.

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Authors
Dura, Polat
Bregitha, Caro V V
te Morsche, Rene H M
Roelofs, Hennie M J
Kristinsson, Jon O
Wobbes, Theo
Witteman, Ben J M
Tan, Adriaan C I T L
Drenth, Joost P H
Peters, Wilbert H M
Útgáfudagur
2013-09

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Citation
Eur. J. Cancer Prev. 2013, 22 (5):417-9.
Útdráttur
Susceptibility to esophageal carcinoma (EC) is influenced by the interaction between genetic and environmental factors. To clarify the etiology of EC, several genome-wide association studies have identified single nucleotide polymorphisms (SNPs) in PCLE1 and RFT2 genes as esophageal squamous cell carcinoma (ESCC) susceptibility loci in Asian populations. This study aimed to determine whether these SNPs also modify the risk of esophageal adenocarcinoma (EAC) and ESCC in western populations of Caucasian ethnicity. A European case-control study including 349 EC patients and 580 controls matched for age, sex, geographical location, and race was carried out. The SNPs rs2274223 in the PCLE1 gene at chromosome 10q23 and rs13042395 in the RFT2 gene at chromosome 20p13 were determined using PCR. Genotype distributions were compared between patients and controls, and odds ratios with 95% confidence intervals were calculated. The total EC group included 86 patients with ESCC and 258 patients with EAC. The distribution of PLCE1 and RFT2 genotypes did not differ between patients with EAC or ESSC, and the controls. In contrast to the modulation of the risk of ESCC in Asians, it is unlikely that the PLCE1 rs2274223 and RFT2 13042395 SNPs play a role in EAC or ESCC susceptibility in Dutch Caucasians.
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http://dx.doi.org/10.1097/CEJ.0b013e32835c7f53
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=&AN=00008469-201309000-00006&PDF=y
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Archived with thanks to European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
ae974a485f413a2113503eed53cd6c53
10.1097/CEJ.0b013e32835c7f53
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English Journal Articles (Peer Reviewed)

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