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dc.contributor.authorDura, Polat
dc.contributor.authorBregitha, Caro V V
dc.contributor.authorte Morsche, Rene H M
dc.contributor.authorRoelofs, Hennie M J
dc.contributor.authorKristinsson, Jon O
dc.contributor.authorWobbes, Theo
dc.contributor.authorWitteman, Ben J M
dc.contributor.authorTan, Adriaan C I T L
dc.contributor.authorDrenth, Joost P H
dc.contributor.authorPeters, Wilbert H M
dc.date.accessioned2014-05-16T11:45:55Z
dc.date.available2014-05-16T11:45:55Z
dc.date.issued2013-09
dc.date.submitted2013
dc.identifier.citationEur. J. Cancer Prev. 2013, 22 (5):417-9.en
dc.identifier.issn1473-5709
dc.identifier.pmid23222411
dc.identifier.doi10.1097/CEJ.0b013e32835c7f53
dc.identifier.urihttp://hdl.handle.net/2336/317056
dc.descriptionTo access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.en
dc.description.abstractSusceptibility to esophageal carcinoma (EC) is influenced by the interaction between genetic and environmental factors. To clarify the etiology of EC, several genome-wide association studies have identified single nucleotide polymorphisms (SNPs) in PCLE1 and RFT2 genes as esophageal squamous cell carcinoma (ESCC) susceptibility loci in Asian populations. This study aimed to determine whether these SNPs also modify the risk of esophageal adenocarcinoma (EAC) and ESCC in western populations of Caucasian ethnicity. A European case-control study including 349 EC patients and 580 controls matched for age, sex, geographical location, and race was carried out. The SNPs rs2274223 in the PCLE1 gene at chromosome 10q23 and rs13042395 in the RFT2 gene at chromosome 20p13 were determined using PCR. Genotype distributions were compared between patients and controls, and odds ratios with 95% confidence intervals were calculated. The total EC group included 86 patients with ESCC and 258 patients with EAC. The distribution of PLCE1 and RFT2 genotypes did not differ between patients with EAC or ESSC, and the controls. In contrast to the modulation of the risk of ESCC in Asians, it is unlikely that the PLCE1 rs2274223 and RFT2 13042395 SNPs play a role in EAC or ESCC susceptibility in Dutch Caucasians.
dc.description.sponsorshipBBMRI-NL, Dutch government/NWO 184.021.007/CP 28/CP2011-02en
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.urlhttp://dx.doi.org/10.1097/CEJ.0b013e32835c7f53en
dc.relation.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=&AN=00008469-201309000-00006&PDF=yen
dc.rightsArchived with thanks to European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)en
dc.subject.meshAdenocarcinomaen
dc.subject.meshCarcinoma, Squamous Cellen
dc.subject.meshCase-Control Studiesen
dc.subject.meshEsophageal Neoplasmsen
dc.subject.meshEuropean Continental Ancestry Groupen
dc.subject.meshFemaleen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshGenome-Wide Association Studyen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMembrane Transport Proteinsen
dc.subject.meshNetherlandsen
dc.subject.meshPhosphoinositide Phospholipase Cen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshRisk Factorsen
dc.titleGWAS-uncovered SNPs in PLCE1 and RFT2 genes are not implicated in Dutch esophageal adenocarcinoma and squamous cell carcinoma etiology.en
dc.typeArticleen
dc.contributor.departmentRadboud Univ Nijmegen, Med Ctr, Dept Gastroenterol, NL-6500 HB Nijmegen, Netherlands, Radboud Univ Nijmegen, Med Ctr, Dept Surg, NL-6500 HB Nijmegen, Netherlands, Canisius Wilhelmina Hosp, Dept Gastroenterol, Nijmegen, Netherlands, Hosp Gelderse Vallei, Dept Gastroenterol, Ede, Netherlandsen
dc.identifier.journalEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)en
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractSusceptibility to esophageal carcinoma (EC) is influenced by the interaction between genetic and environmental factors. To clarify the etiology of EC, several genome-wide association studies have identified single nucleotide polymorphisms (SNPs) in PCLE1 and RFT2 genes as esophageal squamous cell carcinoma (ESCC) susceptibility loci in Asian populations. This study aimed to determine whether these SNPs also modify the risk of esophageal adenocarcinoma (EAC) and ESCC in western populations of Caucasian ethnicity. A European case-control study including 349 EC patients and 580 controls matched for age, sex, geographical location, and race was carried out. The SNPs rs2274223 in the PCLE1 gene at chromosome 10q23 and rs13042395 in the RFT2 gene at chromosome 20p13 were determined using PCR. Genotype distributions were compared between patients and controls, and odds ratios with 95% confidence intervals were calculated. The total EC group included 86 patients with ESCC and 258 patients with EAC. The distribution of PLCE1 and RFT2 genotypes did not differ between patients with EAC or ESSC, and the controls. In contrast to the modulation of the risk of ESCC in Asians, it is unlikely that the PLCE1 rs2274223 and RFT2 13042395 SNPs play a role in EAC or ESCC susceptibility in Dutch Caucasians.


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