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dc.contributor.authorRunarsdottir, Solrun Bjork
dc.contributor.authorGudmundsson, Gunnar
dc.contributor.authorAspelund, Thor
dc.contributor.authorHarris, Tamara B
dc.contributor.authorLauner, Lenore J
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorGislason, Thorarinn
dc.date.accessioned2014-05-19T11:31:12Z
dc.date.available2014-05-19T11:31:12Z
dc.date.issued2013-08
dc.date.submitted2014-05-19
dc.identifier.citationCOPD 2013, 10(4):493-9en
dc.identifier.issn1541-2563
dc.identifier.pmid23875743
dc.identifier.doi10.3109/15412555.2013.773303
dc.identifier.urihttp://hdl.handle.net/2336/317138
dc.descriptionTo access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.en
dc.description.abstractThe prevalence and characteristics of airway obstruction in older individuals varies widely with the definition used. We used a random sample of never smoking older population in Iceland to compare the prevalence and clinical profile of subjects diagnosed with Chronic Obstructive Pulmonary Disease (COPD) based on different spirometric criteria.
dc.description.abstractThe study uses data from the Age, Gene/Environment Susceptibility-Reykjavik Study, comprising survivors from the Reykjavik Study. Procedures included standardized questionnaires and pre-bronchodilator spirometry for measurement of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC).
dc.description.abstractTotal of 495 individuals (150 men and 345 women) met study criteria. Mean age 77 years (range 66-92 years) using fixed ratio (FEV1/FVC < 70%) up to 29% of the population were diagnosed with COPD Stage I. The prevalence of COPD increased with age. Only 7 among 495 (1.4%) were diagnosed with COPD using FEV1/FVC LLN and FEV1 LLN.
dc.description.abstractApplication of the GOLD criteria for diagnosis of COPD in older lifelong never smoking subjects identifies a substantial number of non-symptomatic subjects as having COPD. If airway obstruction is defined by FEV1/FVC and FEV1 being below the LLN using appropriate reference equations, only very few non-smoking older individuals fulfill the criteria for COPD.
dc.description.sponsorshipNIH N01-AG-1-2100 NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association) Althingi (the Icelandic Parliament)en
dc.language.isoenen
dc.publisherInforma Healthcareen
dc.relation.urlhttp://dx.doi.org/10.3109/15412555.2013.773303en
dc.rightsArchived with thanks to COPDen
dc.subject.meshAge Factorsen
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshFemaleen
dc.subject.meshForced Expiratory Volumeen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshMaleen
dc.subject.meshPrevalenceen
dc.subject.meshPulmonary Disease, Chronic Obstructiveen
dc.subject.meshQuestionnairesen
dc.subject.meshSmokingen
dc.subject.meshSpirometryen
dc.subject.meshVital Capacityen
dc.titlePrevalence of airflow obstruction in nonsmoking older individuals using different spirometric criteria: the AGES Reykjavik Study.en
dc.typeArticleen
dc.contributor.departmentLandspitali Univ Hosp, Dept Resp Med & Sleep, IS-108 Reykjavik, Iceland Univ Iceland, Fac Med, Reykjavik, Iceland Iceland Heart Assoc, Kopavogur, Iceland NIA, Labaratory Epidemiol Demog & Biometry, Intramural Res Program, Bethesda, MD 20892 USAen
dc.identifier.journalCOPDen
dc.rights.accessClosed - Lokaðen
html.description.abstractThe prevalence and characteristics of airway obstruction in older individuals varies widely with the definition used. We used a random sample of never smoking older population in Iceland to compare the prevalence and clinical profile of subjects diagnosed with Chronic Obstructive Pulmonary Disease (COPD) based on different spirometric criteria.
html.description.abstractThe study uses data from the Age, Gene/Environment Susceptibility-Reykjavik Study, comprising survivors from the Reykjavik Study. Procedures included standardized questionnaires and pre-bronchodilator spirometry for measurement of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC).
html.description.abstractTotal of 495 individuals (150 men and 345 women) met study criteria. Mean age 77 years (range 66-92 years) using fixed ratio (FEV1/FVC < 70%) up to 29% of the population were diagnosed with COPD Stage I. The prevalence of COPD increased with age. Only 7 among 495 (1.4%) were diagnosed with COPD using FEV1/FVC LLN and FEV1 LLN.
html.description.abstractApplication of the GOLD criteria for diagnosis of COPD in older lifelong never smoking subjects identifies a substantial number of non-symptomatic subjects as having COPD. If airway obstruction is defined by FEV1/FVC and FEV1 being below the LLN using appropriate reference equations, only very few non-smoking older individuals fulfill the criteria for COPD.


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