The role of the palatine tonsils in the pathogenesis and treatment of psoriasis.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationBr. J. Dermatol. 2013, 168(2):237-42
AbstractPsoriasis is a common chronic skin disease with strong genetic associations and environmental triggers. Patients with psoriasis develop sore throats much more frequently than nonpsoriatic individuals and it is well documented that streptococcal throat infections can trigger the onset of psoriasis, and such infections cause exacerbation of chronic psoriasis. It is now generally accepted that psoriatic lesions are caused by abnormal reactivity of specific T lymphocytes in the skin. However, it has been shown in recent years that activation of specific immunity is always preceded by activation of nonspecific innate immune mechanisms, and that abnormalities in the innate immune system can cause dysregulation in specific immune responses. Here we explore the possible immune mechanisms that are involved in the link between infection of the tonsils and this inflammatory skin disease. Moreover, we survey the literature and discuss the suitability of tonsillectomy as a treatment for psoriasis.
DescriptionTo access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.
RightsArchived with thanks to The British journal of dermatology
- Identical TCR beta-chain rearrangements in streptococcal angina and skin lesions of patients with psoriasis vulgaris.
- Authors: Diluvio L, Vollmer S, Besgen P, Ellwart JW, Chimenti S, Prinz JC
- Issue date: 2006 Jun 1
- Tonsillectomy as a treatment for psoriasis: a review.
- Authors: Wu W, Debbaneh M, Moslehi H, Koo J, Liao W
- Issue date: 2014 Dec
- The association of sore throat and psoriasis might be explained by histologically distinctive tonsils and increased expression of skin-homing molecules by tonsil T cells.
- Authors: Sigurdardottir SL, Thorleifsdottir RH, Valdimarsson H, Johnston A
- Issue date: 2013 Oct
- Psoriasis--as an autoimmune disease caused by molecular mimicry.
- Authors: Valdimarsson H, Thorleifsdottir RH, Sigurdardottir SL, Gudjonsson JE, Johnston A
- Issue date: 2009 Oct
- Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants.
- Authors: Thorleifsdottir RH, Sigurdardottir SL, Sigurgeirsson B, Olafsson JH, Sigurdsson MI, Petersen H, Arnadottir S, Gudjonsson JE, Johnston A, Valdimarsson H
- Issue date: 2012 May 15