Sarcoid arthropathy and the association with the human leukocyte antigen. The Icelandic Sarcoidosis Study.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Haraldsdottir, Sigridur Olina
MetadataShow full item record
CitationClin. Exp. Rheumatol. 2013, 31 (5):711-6
AbstractThe aim of the present study was to evaluate whether certain HLA antigens were risk factors for developing sarcoid arthritis and whether HLA antigens appear to account for the phenotype and the resolution of the arthritis condition in an unselected nationwide cohort.
The Icelandic Sarcoidosis Study (ISS) contains all tissue-verified cases of sarcoidosis in Iceland since 1981. Of a total of 234 cases, 39 patients were identified with arthritis and of those 36 delivered a biosample for the study. The patient cohort has previously been described in detail. DNA was isolated from EDTA blood and HLA antigen typing was performed. A total of 544 Icelandic stem cell donors acted as controls.
HLA-B8 and HLA-B14 antigens were more common among those who suffered from sarcoid arthritis (24% vs. 11%, p<0.01; 6.5% vs. 2.4%, p<0.05). DRB1*03 was also found more frequently in patients with sarcoid arthritis compared to controls (28% vs. 11%, p<0.001), while DRB1*04 was less frequently reported (5.6% vs. 17%, p<0.01). No differences were found in the HLA-A distribution between the groups. A higher proportion of patients with chronic arthritis had HLA-A11 than those with resolving joint problems (60% vs. 3.8%).
Our nationwide study of patients with sarcoid arthritis further supports the conclusion that genetics may strongly influence the development and the clinical course of the disease. Furthermore, some HLA antigens may even be protective for the disease. Thus, classification of the major histocompatibility complex may have clinical implications.
DescriptionTo access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.
RightsArchived with thanks to Clinical and experimental rheumatology
- Clinical manifestation, prevalence and prognosis of sarcoid arthropathy. A nationwide study: the Icelandic Sarcoidosis Study.
- Authors: Petursdottir D, Haraldsdottir SO, Gislason T, Gudbjornsson B
- Issue date: 2007 Sep
- HLA-DRB1* association with sarcoidosis.
- Authors: Gonzalez-Gay MA, Lopez-Mejias R, Garcia-Porrua C
- Issue date: 2014 Mar-Apr
- Histologic findings in siblings with acute sarcoid arthritis: association with the B8,DR3 phenotype.
- Authors: Kremer JM
- Issue date: 1986 Jun
- "The sarcoidosis map": a joint survey of clinical and immunogenetic findings in two European countries.
- Authors: Martinetti M, Tinelli C, Kolek V, Cuccia M, Salvaneschi L, Pasturenzi L, Semenzato G, Cipriani A, Bartova A, Luisetti M
- Issue date: 1995 Aug
- Could HLA-DR B1*11 allele be a clue for predicting extra-pulmonary sarcoidosis?
- Authors: Ozyilmaz E, Goruroglu Ozturk O, Yunsel D, Deniz A, Hanta I, Kuleci S, Seydaoglu G, Erken E, Kocabas A
- Issue date: 2014 Jul 8