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dc.contributor.authorSigurdardottir, S L
dc.contributor.authorThorleifsdottir, R H
dc.contributor.authorValdimarsson, H
dc.contributor.authorJohnston, A
dc.date.accessioned2014-05-19T14:22:36Z
dc.date.available2014-05-19T14:22:36Z
dc.date.issued2013-10
dc.date.submitted2014-05-19
dc.identifier.citationClin. Exp. Immunol. 2013, 174(1):139-51en
dc.identifier.issn1365-2249
dc.identifier.pmid23750651
dc.identifier.doi10.1111/cei.12153
dc.identifier.urihttp://hdl.handle.net/2336/317152
dc.descriptionTo access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.en
dc.description.abstractRecent studies have highlighted the involvement of the palatine tonsils in the pathogenesis of psoriasis, particularly among patients with recurrent throat infections. However, the underlying immunological mechanism is not well understood. In this study we confirm that psoriasis tonsils are infected more frequently by β-haemolytic Streptococci, in particular Group C Streptococcus, compared with recurrently infected tonsils from patients without skin disease. Moreover, we show that tonsils from psoriasis patients contained smaller lymphoid follicles that occupied a smaller tissue area, had a lower germinal centre to marginal zone area ratio and contained fewer tingible body macrophages per unit area compared with recurrently infected tonsils from individuals without skin disease. Psoriasis patients' tonsils had a higher frequency of skin-homing [cutaneous lymphocyte-associated antigen (CLA(+) )] CD4(+) and CD8(+) T cells, and this correlated significantly with their frequency of blood CLA(+) T cells. The psoriasis patients also had a higher frequency of tonsil T cells expressing the interleukin (IL)-23 receptor that was expressed preferentially by the CLA(+) T cell population. In contrast, recurrently infected tonsils of individuals without skin disease had a higher frequency of tonsil T cells expressing the activation marker CD69 and a number of chemokine receptors with unknown relevance to psoriasis. These findings suggest that immune responses in the palatine tonsils of psoriasis patients are dysregulated. The elevated expression of CLA and IL-23 receptor by tonsil T cells may promote the egression of effector T cells from tonsils to the epidermis, suggesting that there may be functional changes within the tonsils, which promote triggering or exacerbation of psoriasis.
dc.description.sponsorshipIcelandic Research Fund 080448021-23 Icelandic Research Fund for Graduate Students Landspitali University Hospital Research Fund Research Fund of the University of Iceland for Doctoral Studies Babcock Endowment Fund American Skin Associationen
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://dx.doi.org/10.1111/cei.12153en
dc.rightsArchived with thanks to Clinical and experimental immunologyen
dc.subject.meshClinical Trials as Topicen
dc.subject.meshComorbidityen
dc.subject.meshHumansen
dc.subject.meshMacrophagesen
dc.subject.meshPalatine Tonsilen
dc.subject.meshPharyngitisen
dc.subject.meshPsoriasisen
dc.subject.meshRecurrenceen
dc.subject.meshSkinen
dc.subject.meshStreptococcal Infectionsen
dc.subject.meshT-Lymphocyte Subsetsen
dc.subject.meshUp-Regulationen
dc.titleThe association of sore throat and psoriasis might be explained by histologically distinctive tonsils and increased expression of skin-homing molecules by tonsil T cells.en
dc.typeArticleen
dc.contributor.departmentLandspitali Univ Hosp, Dept Immunol, Reykjavik, Iceland Univ Iceland, Dept Med, Reykjavik, Iceland Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USAen
dc.identifier.journalClinical and experimental immunologyen
dc.rights.accessNational Consortium - Landsaðganguren
html.description.abstractRecent studies have highlighted the involvement of the palatine tonsils in the pathogenesis of psoriasis, particularly among patients with recurrent throat infections. However, the underlying immunological mechanism is not well understood. In this study we confirm that psoriasis tonsils are infected more frequently by β-haemolytic Streptococci, in particular Group C Streptococcus, compared with recurrently infected tonsils from patients without skin disease. Moreover, we show that tonsils from psoriasis patients contained smaller lymphoid follicles that occupied a smaller tissue area, had a lower germinal centre to marginal zone area ratio and contained fewer tingible body macrophages per unit area compared with recurrently infected tonsils from individuals without skin disease. Psoriasis patients' tonsils had a higher frequency of skin-homing [cutaneous lymphocyte-associated antigen (CLA(+) )] CD4(+) and CD8(+) T cells, and this correlated significantly with their frequency of blood CLA(+) T cells. The psoriasis patients also had a higher frequency of tonsil T cells expressing the interleukin (IL)-23 receptor that was expressed preferentially by the CLA(+) T cell population. In contrast, recurrently infected tonsils of individuals without skin disease had a higher frequency of tonsil T cells expressing the activation marker CD69 and a number of chemokine receptors with unknown relevance to psoriasis. These findings suggest that immune responses in the palatine tonsils of psoriasis patients are dysregulated. The elevated expression of CLA and IL-23 receptor by tonsil T cells may promote the egression of effector T cells from tonsils to the epidermis, suggesting that there may be functional changes within the tonsils, which promote triggering or exacerbation of psoriasis.


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