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Persistence of the effect of birth size on dysglycaemia and type 2 diabetes in old age: AGES-Reykjavik Study.

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Authors
von Bonsdorff, Mikaela B
Muller, Majon
Aspelund, Thor
Garcia, Melissa
Eiriksdottir, Gudny
Rantanen, Taina
Gunnarsdottir, Ingibjörg
Birgisdottir, Bryndis Eva
Thorsdottir, Inga
Sigurdsson, Gunnar
Gudnason, Vilmundur
Launer, Lenore
Harris, Tamara B
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Issue Date
2013-08

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Age (Dordr) 2013, 35(4):1401-9
Abstract
We studied the effect of birth size on glucose and insulin metabolism among old non-diabetic individuals. We also explored the combined effect of birth size and midlife body mass index (BMI) on type 2 diabetes in old age. Our study comprised 1,682 Icelanders whose birth records included anthropometrical data. The same individuals had participated in the prospective population-based Reykjavik Study, where BMI was assessed at a mean age of 47 years, and in the AGES-Reykjavik Study during 2002 to 2006, where fasting glucose, insulin and HbA1c were measured and homeostasis model assessment for the degree of insulin resistance (HOMA-IR) calculated at a mean age of 75.5 years. Type 2 diabetes was determined as having a history of diabetes, using glucose-modifying medication or fasting glucose of >7.0 mmol/l. Of the participants, 249 had prevalent type 2 diabetes in old age. Lower birth weight and body length were associated with higher fasting glucose, insulin, HOMA-IR and HbA1c among old non-diabetic individuals. Higher birth weight and ponderal index at birth decreased the risk for type 2 diabetes in old age, odds ratio (OR), 0.61 [95 % confidence interval (CI), 0.48-0.79] and 0.96 (95 % CI, 0.92-1.00), respectively. Compared with those with high birth weight and low BMI in midlife, the odds of diabetes was almost five-fold for individuals with low birth weight and high BMI (OR, 4.93; 95 % CI, 2.14-11.37). Excessive weight gain in adulthood might be particularly detrimental to the health of old individuals with low birth weight.
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http://dx.doi.org/10.1007/s11357-012-9427-5
http://link.springer.com/article/10.1007%2Fs11357-012-9427-5
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Archived with thanks to Age (Dordrecht, Netherlands)
ae974a485f413a2113503eed53cd6c53
10.1007/s11357-012-9427-5
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English Journal Articles (Peer Reviewed)

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