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dc.contributor.authorZoega, Gunnar M
dc.contributor.authorArnarsson, Arsaell
dc.contributor.authorSasaki, Hiroshi
dc.contributor.authorSöderberg, Per G
dc.contributor.authorJonasson, Fridbert
dc.date.accessioned2014-05-26T13:53:55Z
dc.date.available2014-05-26T13:53:55Z
dc.date.issued2013-05
dc.date.submitted2014-05-26
dc.identifier.citationActa Ophthalmol 2013, 91(3):212-8en
dc.identifier.issn1755-3768
dc.identifier.pmid22339815
dc.identifier.doi10.1111/j.1755-3768.2011.02360.x
dc.identifier.urihttp://hdl.handle.net/2336/317469
dc.descriptionTo access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.en
dc.description.abstractTo examine the corneal endothelium and establish the 7-year cumulative incidence of cornea guttata (CG).
dc.description.abstractPopulation-based prospective cohort study with 573 participants (third wave of the Reykjavik Eye Study (RES) in 2008). Four hundred and thirty-seven subjects had either right or left eyes available for analysis after excluding confounding eye conditions. The baseline for eyes at risk for developing CG is the second wave of the RES in 2001. Participants underwent specular microscopy and a standardized eye examination.
dc.description.abstractThe cumulative 7-year incidence of CG in either eye was estimated as a 95% confidence interval for the expected value for both genders combined (15-23%), for males (8-18%) and for females (19-29%). In right eye only, the 7-year cumulative incidence for both genders combined was estimated to be 6-11%. For genders combined and for males only, the data indicated no correlation between 7-year cumulated incidence and age at baseline. In women, however, the change of 7-year incidence for CG in at least one eye appeared to be correlated to age at baseline. Reduction of endothelial cell density for corneas with CG at baseline was found [CI (0.95)-132 ± 94].
dc.description.abstractThe cumulative 7-year incidence of primary central CG for a middle-aged and older Caucasian population without history of potentially confounding eye disease has been established. Women tend to have higher incidence if onset occurs at middle age. If CG is present, the cell density and the cell size variation decrease within a 7-year period.
dc.description.sponsorshipHelga Jonsdottir and Sigurlidi Kristjansson Memorial Research Funden
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://dx.doi.org/10.1111/j.1755-3768.2011.02360.xen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1755-3768.2011.02360.x/pdfen
dc.rightsArchived with thanks to Acta ophthalmologicaen
dc.subject.meshAge Distributionen
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshCell Counten
dc.subject.meshCorneal Diseasesen
dc.subject.meshCorneal Pachymetryen
dc.subject.meshDescemet Membraneen
dc.subject.meshEndothelium, Cornealen
dc.subject.meshEuropean Continental Ancestry Groupen
dc.subject.meshFemaleen
dc.subject.meshFinlanden
dc.subject.meshFollow-Up Studiesen
dc.subject.meshHumansen
dc.subject.meshIncidenceen
dc.subject.meshMaleen
dc.subject.meshMicroscopyen
dc.subject.meshMiddle Ageden
dc.subject.meshProspective Studiesen
dc.subject.meshSex Distributionen
dc.subject.meshTime Factorsen
dc.titleThe 7-year cumulative incidence of cornea guttata and morphological changes in the corneal endothelium in the Reykjavik Eye Study.en
dc.typeArticleen
dc.contributor.departmentUppsala Univ, Dept Neurosci, Gullstrand Lab, Uppsala, Sweden Univ Akureyri, Akureyri, Iceland Kanazawa Med Univ, Dept Ophthalmol, Uchinada, Ishikawa 92002, Japan Univ Iceland, Dept Ophthalmol, IS-101 Reykjavik, Iceland Landspitali Univ Hosp IS-101 Reykjavik, Icelanden
dc.identifier.journalActa ophthalmologicaen
dc.rights.accessNational Consortium - Landsaðganguren
html.description.abstractTo examine the corneal endothelium and establish the 7-year cumulative incidence of cornea guttata (CG).
html.description.abstractPopulation-based prospective cohort study with 573 participants (third wave of the Reykjavik Eye Study (RES) in 2008). Four hundred and thirty-seven subjects had either right or left eyes available for analysis after excluding confounding eye conditions. The baseline for eyes at risk for developing CG is the second wave of the RES in 2001. Participants underwent specular microscopy and a standardized eye examination.
html.description.abstractThe cumulative 7-year incidence of CG in either eye was estimated as a 95% confidence interval for the expected value for both genders combined (15-23%), for males (8-18%) and for females (19-29%). In right eye only, the 7-year cumulative incidence for both genders combined was estimated to be 6-11%. For genders combined and for males only, the data indicated no correlation between 7-year cumulated incidence and age at baseline. In women, however, the change of 7-year incidence for CG in at least one eye appeared to be correlated to age at baseline. Reduction of endothelial cell density for corneas with CG at baseline was found [CI (0.95)-132 ± 94].
html.description.abstractThe cumulative 7-year incidence of primary central CG for a middle-aged and older Caucasian population without history of potentially confounding eye disease has been established. Women tend to have higher incidence if onset occurs at middle age. If CG is present, the cell density and the cell size variation decrease within a 7-year period.


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