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dc.contributor.authorCanova, Cristina
dc.contributor.authorHeinrich, Joachim
dc.contributor.authorAnto, Josep Maria
dc.contributor.authorLeynaert, Benedicte
dc.contributor.authorSmith, Matthew
dc.contributor.authorKuenzli, Nino
dc.contributor.authorZock, Jan-Paul
dc.contributor.authorJanson, Christer
dc.contributor.authorCerveri, Isa
dc.contributor.authorde Marco, Roberto
dc.contributor.authorToren, Kjell
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorNowak, Dennis
dc.contributor.authorPin, Isabelle
dc.contributor.authorWjst, Matthias
dc.contributor.authorManfreda, Jure
dc.contributor.authorSvanes, Cecilie
dc.contributor.authorCrane, Julian
dc.contributor.authorAbramson, Michael
dc.contributor.authorBurr, Michael
dc.contributor.authorBurney, Peter
dc.contributor.authorJarvis, Deborah
dc.date.accessioned2014-06-03T14:10:17Z
dc.date.available2014-06-03T14:10:17Z
dc.date.issued2013-10
dc.date.submitted2013
dc.identifier.citationEur. Respir. J. 2013, 42 (4):935-45en
dc.identifier.issn1399-3003
dc.identifier.pmid23471350
dc.identifier.doi10.1183/09031936.00097412
dc.identifier.urihttp://hdl.handle.net/2336/317795
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.en
dc.description.abstractNo large study has described the seasonal variation in asthma attacks in population-based asthmatics in whom sensitisation to allergen has been measured. 2,637 young adults with asthma living in 15 countries reported the months in which they usually had attacks of asthma and had skin-prick tests performed. Differences in seasonal patterns by sensitisation status were assessed using generalised estimating equations. Most young adults with asthma reported periods of the year when their asthma attacks were more common (range: 47% in Sweden to 86% in Spain). Seasonal variation in asthma was not modified by sensitisation to house dust mite or cat allergens. Asthmatics sensitised to grass, birch and Alternaria allergens had different seasonal patterns to those not sensitised to each allergen, with some geographical variation. In southern Europe, those sensitised to grass allergens were more likely to report attacks occurred in spring or summer than in winter (OR March/April 2.60, 95% CI 1.70-3.97; OR May/June 4.43, 95% CI 2.34-8.39) and smaller later peaks were observed in northern Europe (OR May/June 1.25, 95% CI 0.60-2.64; OR July/August 1.66, 95% CI 0.89-3.10). Asthmatics reporting hay fever but who were not sensitised to grass showed no seasonal variations. Seasonal variations in asthma attacks in young adults are common and are different depending on sensitisation to outdoor, but not indoor, allergens.
dc.language.isoenen
dc.publisherEuropean Respiratory Soc Journalsen
dc.relation.urlhttp://erj.ersjournals.com/content/42/4/935.longen
dc.relation.urlhttp://dx.doi.org/10.1183/09031936.00097412en
dc.rightsArchived with thanks to The European respiratory journalen
dc.subjectAsmaen
dc.subjectOfnæmien
dc.subject.meshAdulten
dc.subject.meshAllergensen
dc.subject.meshAlternariaen
dc.subject.meshAsthmaen
dc.subject.meshBetulaen
dc.subject.meshEuropeen
dc.subject.meshFemaleen
dc.subject.meshFollow-Up Studiesen
dc.subject.meshFungien
dc.subject.meshHumansen
dc.subject.meshImmunoglobulin Een
dc.subject.meshMaleen
dc.subject.meshOdds Ratioen
dc.subject.meshPoaceaeen
dc.subject.meshPollenen
dc.subject.meshQuestionnairesen
dc.subject.meshRandom Allocationen
dc.subject.meshRhinitis, Allergic, Seasonalen
dc.subject.meshRisken
dc.subject.meshSeasonsen
dc.subject.meshSkin Testsen
dc.subject.meshYoung Adulten
dc.titleThe influence of sensitisation to pollens and moulds on seasonal variations in asthma attacks.en
dc.typeArticleen
dc.contributor.departmentUniv London Imperial Coll Sci Technol & Med, London, England, Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, MRC HPA Ctr Environm & Hlth, London, England, Cardiff Univ, Dept Primary Care & Publ Hlth, Cardiff CF10 3AX, S Glam, Wales, German Res Ctr Environm Hlth, Helmholtz Ctr Munich, Neuherberg, Germany, Univ Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany, German Res Ctr Environm Hlth, Helmholtz Ctr Munich, CPC Comprehens Pneumol Ctr, Inst Lung Biol & Dis, Munich, Germany, Ctr Res Environm Epidemiol CREAL, Barcelona, Spain, Hosp Mar Res Inst IMIM, Barcelona, Spain, CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain, Univ Pompeu Fabra, Dept Life Expt Sci, Barcelona, Spain, INSERM, Natl Inst Hlth & Med Res, U700, Paris, France, Univ Grenoble 1, CHU Grenoble, INSERM, U823,Inst Albert Bonniot, Grenoble, France, Med Univ Vienna, Dept Otorhinolaryngol, Res Unit Aerobiol & Pollen Informat, Vienna, Austria, Univ Basel, Basel, Switzerland, Swiss Trop & Publ Hlth Inst Swiss TPH, Basel, Switzerland, Uppsala Univ, Dept Med Sci Resp Med & Allergol, Uppsala, Sweden, Univ Gothenburg, Inst Med, Sect Occupat & Environm Med, Gothenburg, Sweden, Univ Pavia, Clin Malattie Apparato Resp, Fdn Ricovero & Cura Carattere Sci Policlin S Matt, I-27100 Pavia, Italy, Univ Verona, Dept Med & Publ Hlth, Unit Epidemiol & Med Stat, I-37100 Verona, Italy, Univ Iceland, Fac Med, Reykjavik, Iceland, Univ Manitoba, Dept Med, Winnipeg, MB, Canada, Univ Bergen, Inst Med, Bergen, Norway, Univ Otago, Asthma Res Grp, Wellington, New Zealand, Monash Univ, Melbourne, Vic 3004, Australiaen
dc.identifier.journalThe European respiratory journalen
dc.rights.accessOpen Access - Opinn aðganguren
refterms.dateFOA2018-09-12T13:20:45Z
html.description.abstractNo large study has described the seasonal variation in asthma attacks in population-based asthmatics in whom sensitisation to allergen has been measured. 2,637 young adults with asthma living in 15 countries reported the months in which they usually had attacks of asthma and had skin-prick tests performed. Differences in seasonal patterns by sensitisation status were assessed using generalised estimating equations. Most young adults with asthma reported periods of the year when their asthma attacks were more common (range: 47% in Sweden to 86% in Spain). Seasonal variation in asthma was not modified by sensitisation to house dust mite or cat allergens. Asthmatics sensitised to grass, birch and Alternaria allergens had different seasonal patterns to those not sensitised to each allergen, with some geographical variation. In southern Europe, those sensitised to grass allergens were more likely to report attacks occurred in spring or summer than in winter (OR March/April 2.60, 95% CI 1.70-3.97; OR May/June 4.43, 95% CI 2.34-8.39) and smaller later peaks were observed in northern Europe (OR May/June 1.25, 95% CI 0.60-2.64; OR July/August 1.66, 95% CI 0.89-3.10). Asthmatics reporting hay fever but who were not sensitised to grass showed no seasonal variations. Seasonal variations in asthma attacks in young adults are common and are different depending on sensitisation to outdoor, but not indoor, allergens.


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