Acidification of distal esophagus and sleep-related breathing disturbances
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationChest 2004, 125(6):2101-6
ÚtdrátturSTUDY OBJECTIVES: To investigate whether distal esophageal acidification occurs during sleep in patients suspected of sleep-disordered breathing, and whether such acidification is related to respiratory abnormalities. DESIGN AND PATIENTS: Fourteen middle-aged, snoring men all complaining of daytime sleepiness and suspected of having obstructive sleep apnea. SETTING: Sleep laboratory, Pulmonary Department, Landspitali University Hospital, Reykjavik, Iceland. MEASUREMENTS AND RESULTS: Each patient underwent full nocturnal polysomnography testing, which included continuous monitoring of esophageal pressure (Pes) and pH. We identified all pH events, which were defined as a reduction in esophageal pH of >/= 1.0. During each pH event, the respiratory recordings where examined for the presence of apneas or hypopneas, and Pes was recorded. The data were analyzed to determine the possible relationships between pH events and respiratory events, and between changes in pH and changes in Pes. We found that there were more respiratory events than pH events. The mean (+/- SD) number of apneas and hypopneas per hour of sleep was 33 +/- 22, whereas the mean number of pH events per hour of sleep was 7 +/- 6. Overall, 81% of all pH events were associated with respiratory events. Correlation analysis did not reveal any significant relationship between pH events and the magnitude of Pes or apnea-hypopnea index. CONCLUSIONS: Episodes of esophageal acidification are common in patients with sleep apnea, and are usually associated with respiratory and pressure events. However, changes in pH were independent of the magnitude of the Pes.
Lu00FDsingTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Variables affecting the occurrence of gastroesophageal reflux in obstructive sleep apnea patients.
- Authors: Oztürk O, Oztürk L, Ozdogan A, Oktem F, Pelin Z
- Issue date: 2004 Apr
- Obstructive hypopnea and gastroesophageal reflux as factors associated with residual obstructive sleep apnea syndrome.
- Authors: Wasilewska J, Kaczmarski M, Debkowska K
- Issue date: 2011 May
- Mechanisms of nocturnal gastroesophageal reflux events in obstructive sleep apnea.
- Authors: Shepherd K, Hillman D, Holloway R, Eastwood P
- Issue date: 2011 Sep
- Arousals in obstructive sleep apnea patients with laryngopharyngeal and gastroesophageal reflux.
- Authors: Suzuki M, Saigusa H, Kurogi R, Yamamoto T, Ishiguro T, Yohsizawa T, Kuyama Y, Furukawa T
- Issue date: 2010 Apr
- Obstructive sleep apnea and gastroesophageal reflux.
- Authors: Ing AJ, Ngu MC, Breslin AB
- Issue date: 2000 Mar 6