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dc.contributor.authorBruinsma, Nienke
dc.contributor.authorKristinsson, Karl G
dc.contributor.authorBronzwaer, Stef
dc.contributor.authorSchrijnemakers, Paul
dc.contributor.authorDegener, John
dc.contributor.authorTiemersma, Edine
dc.contributor.authorHryniewicz, Waleria
dc.contributor.authorMonen, Jos
dc.contributor.authorGrundmann, Hajo
dc.date.accessioned2006-06-29T12:18:09Z
dc.date.available2006-06-29T12:18:09Z
dc.date.issued2004
dc.identifier.citationJ. Antimicrob. Chemother. 2004, 54(6):1045-50en
dc.identifier.issn0305-7453
dc.identifier.pmid15531598
dc.identifier.doi10.1093/jac/dkh458
dc.identifier.urihttp://hdl.handle.net/2336/3198
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVES: To forecast trends in resistance to penicillin and erythromycin among Streptococcus pneumoniae in Europe. METHODS: Since 1999, the European Antimicrobial Resistance Surveillance System (EARSS) has collected routine antimicrobial susceptibility test results of S. pneumoniae. To observe and predict changes of reduced susceptibility over time, we used a multinomial logistic regression model. RESULTS: Large variations in penicillin and erythromycin non-susceptibility were observed between countries, and reduced susceptibility to erythromycin (17%) has become more frequent than reduced susceptibility to penicillin (10%) in Europe overall. An overall decrease in single penicillin non-susceptibility, but an increase in dual non-susceptibility was observed, indicating a shift of single penicillin to combined non-susceptibility with erythromycin. By 2006, the proportion of single erythromycin and dual non-susceptibility could increase to as much as 20.4% and 8.9%, respectively. CONCLUSIONS: Our results indicate that appropriately dosed beta-lactams for empirical therapy are still the treatment of choice, and that macrolides should be used with prudence.
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urlhttp://jac.oxfordjournals.org/cgi/content/abstract/54/6/1045en
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAnti-Bacterial Agentsen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectDrug Resistance, Bacterialen
dc.subjectErythromycinen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLogistic Modelsen
dc.subjectMaleen
dc.subjectMicrobial Sensitivity Testsen
dc.subjectMiddle Ageden
dc.subjectPenicillin Resistanceen
dc.subjectPenicillinsen
dc.subjectPneumococcal Infectionsen
dc.subjectPopulation Surveillanceen
dc.subjectResearch Support, Non-U.S. Gov'ten
dc.subjectStreptococcus pneumoniaeen
dc.titleTrends of penicillin and erythromycin resistance among invasive Streptococcus pneumoniae in Europeen
dc.typeArticleen
dc.identifier.journalJournal of antimicrobial chemotherapyen
dc.format.digYES
html.description.abstractOBJECTIVES: To forecast trends in resistance to penicillin and erythromycin among Streptococcus pneumoniae in Europe. METHODS: Since 1999, the European Antimicrobial Resistance Surveillance System (EARSS) has collected routine antimicrobial susceptibility test results of S. pneumoniae. To observe and predict changes of reduced susceptibility over time, we used a multinomial logistic regression model. RESULTS: Large variations in penicillin and erythromycin non-susceptibility were observed between countries, and reduced susceptibility to erythromycin (17%) has become more frequent than reduced susceptibility to penicillin (10%) in Europe overall. An overall decrease in single penicillin non-susceptibility, but an increase in dual non-susceptibility was observed, indicating a shift of single penicillin to combined non-susceptibility with erythromycin. By 2006, the proportion of single erythromycin and dual non-susceptibility could increase to as much as 20.4% and 8.9%, respectively. CONCLUSIONS: Our results indicate that appropriately dosed beta-lactams for empirical therapy are still the treatment of choice, and that macrolides should be used with prudence.


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