Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsSchwartz, Ann V
Hue, Trisha F
Lang, Thomas F
Harris, Tamara B
Rosen, Clifford J
MetadataShow full item record
CitationJ. Clin. Endocrinol. Metab. 2013, 98 (6):2294-300
AbstractBone marrow fat (BMF) and bone mineral density (BMD) by dual x-ray energy absorptiometry (DXA) are negatively correlated. However, little is known about the association of BMF with fracture or with separate trabecular and cortical bone compartments.
Our objective was to assess the relationships between vertebral BMF, BMD by quantitative computed tomography, and fracture in older adults.
We conducted a cross-sectional study in the Age Gene/Environment Susceptibility-Reykjavik cohort.
Outcomes measures included vertebral BMF (L1-L4) measured with magnetic resonance spectroscopy, quantitative computed tomography and DXA scans of the hip and spine, and DXA vertebral fracture assessments. Previous clinical fracture was determined from medical records.
In 257 participants without recent bone-active medication use, mean age was 79 (SD 3.1) years. Mean BMF was 53.5% ± 8.1% in men and 55.0% ± 8.4% in women. Those with prevalent vertebral fracture (21 men, 32 women) had higher mean BMF in models adjusted for BMD. In separate models by sex, the difference was statistically significant only in men (57.3% vs 52.8%, P = 0.02). BMF was associated with lower trabecular volumetric BMD (vBMD) at the spine (-10.5% difference for each 1 SD increase in BMF, P < 0.01), total hip, and femoral neck, but not with cortical vBMD, in women. In men, BMF was marginally associated with trabecular spine vBMD (-6.1%, P = 0.05). Total hip and spine areal BMD (aBMD) were negatively correlated with BMF in women only.
Higher marrow fat correlated with lower trabecular, but not cortical, BMD in older women but not men. Higher marrow fat was associated with prevalent vertebral fracture in men, even after adjustment for BMD.
DescriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the page
RightsArchived with thanks to The Journal of clinical endocrinology and metabolism
- Circulating sclerostin associated with vertebral bone marrow fat in older men but not women.
- Authors: Ma YH, Schwartz AV, Sigurdsson S, Hue TF, Lang TF, Harris TB, Rosen CJ, Vittinghoff E, Eiriksdottir G, Hauksdottir AM, Siggeirsdottir K, Sigurdsson G, Oskarsdottir D, Napoli N, Palermo L, Gudnason V, Li X
- Issue date: 2014 Dec
- Vertebral bone marrow fat, bone mineral density and diabetes: The Osteoporotic Fractures in Men (MrOS) study.
- Authors: Sheu Y, Amati F, Schwartz AV, Danielson ME, Li X, Boudreau R, Cauley JA, Osteoporotic Fractures in Men (MrOS) Research Group.
- Issue date: 2017 Apr
- Areal and volumetric bone mineral density and risk of multiple types of fracture in older men.
- Authors: Chalhoub D, Orwoll ES, Cawthon PM, Ensrud KE, Boudreau R, Greenspan S, Newman AB, Zmuda J, Bauer D, Cummings S, Cauley JA, Osteoporotic Fractures in Men (MrOS) Study Research Group.
- Issue date: 2016 Nov
- Trabecular volumetric bone mineral density is associated with previous fracture during childhood and adolescence in males: the GOOD study.
- Authors: Darelid A, Ohlsson C, Rudäng R, Kindblom JM, Mellström D, Lorentzon M
- Issue date: 2010 Mar
- Association of moderate/severe vertebral fractures with reduced trabecular volumetric bone density in older women and reduced areal femoral neck bone density in older men from the community: A cross-sectional study (SPAH).
- Authors: Torres GHF, Guzman LFE, Alvarenga JC, Lopes NHM, Pereira RMR
- Issue date: 2019 Feb