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dc.contributor.authorSchwartz, Ann V
dc.contributor.authorSigurdsson, Sigurdur
dc.contributor.authorHue, Trisha F
dc.contributor.authorLang, Thomas F
dc.contributor.authorHarris, Tamara B
dc.contributor.authorRosen, Clifford J
dc.contributor.authorVittinghoff, Eric
dc.contributor.authorSiggeirsdottir, Kristin
dc.contributor.authorSigurdsson, Gunnar
dc.contributor.authorOskarsdottir, Diana
dc.contributor.authorShet, Keerthi
dc.contributor.authorPalermo, Lisa
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorLi, Xiaojuan
dc.date.accessioned2014-07-03T15:26:39Z
dc.date.available2014-07-03T15:26:39Z
dc.date.issued2013-06
dc.date.submitted2014
dc.identifier.citationJ. Clin. Endocrinol. Metab. 2013, 98 (6):2294-300en
dc.identifier.issn1945-7197
dc.identifier.pmid23553860
dc.identifier.doi10.1210/jc.2012-3949
dc.identifier.urihttp://hdl.handle.net/2336/322368
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractBone marrow fat (BMF) and bone mineral density (BMD) by dual x-ray energy absorptiometry (DXA) are negatively correlated. However, little is known about the association of BMF with fracture or with separate trabecular and cortical bone compartments.
dc.description.abstractOur objective was to assess the relationships between vertebral BMF, BMD by quantitative computed tomography, and fracture in older adults.
dc.description.abstractWe conducted a cross-sectional study in the Age Gene/Environment Susceptibility-Reykjavik cohort.
dc.description.abstractOutcomes measures included vertebral BMF (L1-L4) measured with magnetic resonance spectroscopy, quantitative computed tomography and DXA scans of the hip and spine, and DXA vertebral fracture assessments. Previous clinical fracture was determined from medical records.
dc.description.abstractIn 257 participants without recent bone-active medication use, mean age was 79 (SD 3.1) years. Mean BMF was 53.5% ± 8.1% in men and 55.0% ± 8.4% in women. Those with prevalent vertebral fracture (21 men, 32 women) had higher mean BMF in models adjusted for BMD. In separate models by sex, the difference was statistically significant only in men (57.3% vs 52.8%, P = 0.02). BMF was associated with lower trabecular volumetric BMD (vBMD) at the spine (-10.5% difference for each 1 SD increase in BMF, P < 0.01), total hip, and femoral neck, but not with cortical vBMD, in women. In men, BMF was marginally associated with trabecular spine vBMD (-6.1%, P = 0.05). Total hip and spine areal BMD (aBMD) were negatively correlated with BMF in women only.
dc.description.abstractHigher marrow fat correlated with lower trabecular, but not cortical, BMD in older women but not men. Higher marrow fat was associated with prevalent vertebral fracture in men, even after adjustment for BMD.
dc.description.sponsorshipNational Institute of Arthritis and Musculoskeletal and Skin Diseases/R01AR057819 National Institutes of Health/N01-AG-12100 National Institute on Aging Intramural Research Program Althingi (The Icelandic Parliament) National Institute of Diabetes and Digestive and Kidney Diseases/R24DK092759 Hjartavernd (The Icelandic Heart Association)en
dc.language.isoenen
dc.publisherEndocrine Societyen
dc.relation.urlhttp://dx.doi.org/10.1210/jc.2012-3949en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667265/en
dc.rightsArchived with thanks to The Journal of clinical endocrinology and metabolismen
dc.subjectBeinþéttnien
dc.subjectAldraðiren
dc.subjectBeinmerguren
dc.subjectKonuren
dc.subjectBeinbroten
dc.subjectHryggurinnen
dc.subject.meshAdipose Tissueen
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshBone Densityen
dc.subject.meshBone Marrowen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshSpinal Fracturesen
dc.titleVertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults.en
dc.typeArticleen
dc.contributor.departmentUniv Calif San Francisco, San Francisco, CA 94107 USA, Iceland Heart Assoc, IS-201 Kopavogur, Iceland, NIA, Lab Epidemiol Demog & Biometry, Intramural Res Program, Bethesda, MD 20892 USA, Maine Med Ctr Res Inst, Scarborough, ME 04074 USA, Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland, Landspitali Univ Hosp, Dept Endocrinol & Metab, IS-101 Reykjavik, Icelanden
dc.identifier.journalThe Journal of clinical endocrinology and metabolismen
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractBone marrow fat (BMF) and bone mineral density (BMD) by dual x-ray energy absorptiometry (DXA) are negatively correlated. However, little is known about the association of BMF with fracture or with separate trabecular and cortical bone compartments.
html.description.abstractOur objective was to assess the relationships between vertebral BMF, BMD by quantitative computed tomography, and fracture in older adults.
html.description.abstractWe conducted a cross-sectional study in the Age Gene/Environment Susceptibility-Reykjavik cohort.
html.description.abstractOutcomes measures included vertebral BMF (L1-L4) measured with magnetic resonance spectroscopy, quantitative computed tomography and DXA scans of the hip and spine, and DXA vertebral fracture assessments. Previous clinical fracture was determined from medical records.
html.description.abstractIn 257 participants without recent bone-active medication use, mean age was 79 (SD 3.1) years. Mean BMF was 53.5% ± 8.1% in men and 55.0% ± 8.4% in women. Those with prevalent vertebral fracture (21 men, 32 women) had higher mean BMF in models adjusted for BMD. In separate models by sex, the difference was statistically significant only in men (57.3% vs 52.8%, P = 0.02). BMF was associated with lower trabecular volumetric BMD (vBMD) at the spine (-10.5% difference for each 1 SD increase in BMF, P < 0.01), total hip, and femoral neck, but not with cortical vBMD, in women. In men, BMF was marginally associated with trabecular spine vBMD (-6.1%, P = 0.05). Total hip and spine areal BMD (aBMD) were negatively correlated with BMF in women only.
html.description.abstractHigher marrow fat correlated with lower trabecular, but not cortical, BMD in older women but not men. Higher marrow fat was associated with prevalent vertebral fracture in men, even after adjustment for BMD.


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