HLA-Cw6-positive and HLA-Cw6-negative patients with Psoriasis vulgaris have distinct clinical features.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Gudjonsson, Johann EKarason, Ari
Antonsdottir, Arna A
Rúnarsdottir, E Hjaltey
Gulcher, Jeffrey R
Stefansson, Kari
Valdimarsson, Helgi
Issue Date
2002-02-01
Metadata
Show full item recordCitation
J. Invest. Dermatol. 2002, 118(2):362-5Abstract
Psoriasis is associated with HLA-Cw6, and Caucasians who carry this allele have about a 10-fold increased risk of developing psoriasis. We have HLA-C typed 369 patients with familial psoriasis and compared the clinical features of the patients carrying HLA-Cw6 against those carrying other HLA-C types. Some striking clinical differences were observed between the two groups. Patients who are Cw6 positive had a lower age at onset (p=3x10(-7)). Cw6-positive women had an earlier disease onset than Cw6-positive men (p =0.02), but such a difference was not observed for the Cw6-negative patients. The guttate-type onset of psoriasis was mostly confined to this group (p=2x10(-4)) and persistent disseminated guttate-like papules were also predominantly observed in the Cw6-positive patients (p <10(-)4). The Cw6-positive patients also had more extensive plaques on their arms, legs, and trunk (p =0.001), more severe disease (p =0.003), higher incidence of the Koebner's phenomenon (p =0.005), reported more often that their psoriasis got worse during or after throat infections (p =0.02), and more often a favorable response to sunlight (p =0.008) In contrast, dystrophic nail changes were more common in the Cw6-negative patients (p =0.002) and also psoriatic arthritis, although this was not significant (p =0.135). It is concluded that patients with psoriasis have different clinical features depending on whether they are HLA-Cw6 positive or negative.Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldAdditional Links
http://dx.doi.org/10.1046/j.0022-202x.2001.01656.xae974a485f413a2113503eed53cd6c53
10.1046/j.0022-202x.2001.01656.x
Scopus Count
Collections
Related articles
- Comparison of clinical features of HLA-Cw*0602-positive and -negative psoriasis patients in a Han Chinese population.
- Authors: Fan X, Yang S, Sun LD, Liang YH, Gao M, Zhang KY, Huang W, Zhang X
- Issue date: 2007
- Distinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patients--an analysis of 1019 HLA-C- and HLA-B-typed patients.
- Authors: Gudjonsson JE, Karason A, Runarsdottir EH, Antonsdottir AA, Hauksson VB, Jónsson HH, Gulcher J, Stefansson K, Valdimarsson H
- Issue date: 2006 Apr
- HLA antigens may influence the age of onset of psoriasis and psoriatic arthritis.
- Authors: Queiro R, Torre JC, González S, López-Larrea C, Tinturé T, López-Lagunas I
- Issue date: 2003 Mar
- Clinical profile of childhood-onset psoriasis and prevalence of HLA-Cw6: a hospital-based study from India.
- Authors: Sathishkumar D, George R, Daniel D, Peter JV
- Issue date: 2015 Jun
- Clinical associations of the risk alleles of HLA-Cw6 and CCHCR1*WWCC in psoriasis.
- Authors: Suomela S, Kainu K, Onkamo P, Tiala I, Himberg J, Koskinen L, Snellman E, Karvonen SL, Karvonen J, Uurasmaa T, Reunala T, Kivikäs K, Jansén CT, Holopainen P, Elomaa O, Kere J, Saarialho-Kere U
- Issue date: 2007