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Do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation?

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Authors
Bjorgvinsdottir, Lara
Arnar, David O
Indridason, Olafur S
Heidarsdottir, Ragnhildur
Skogstrand, Kristin
Torfason, Bjarni
Hougaard, David M
Palsson, Runolfur
Skuladottir, Gudrun V
Issue Date
2013

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Citation
Cardiology 2013, 126 (2):107-14
Abstract
Postoperative atrial fibrillation (POAF) has been associated with an inflammatory response to the surgical procedure. n-3 long-chain polyunsaturated fatty acids (LC-PUFA) have been proposed for the prevention of POAF. We investigated the relationship between the plasma concentration of inflammatory mediators, levels of n-3 LC-PUFA in red blood cell (RBC) membrane lipids, and the risk of POAF after coronary artery bypass grafting (CABG).
A total of 125 patients who underwent CABG were studied. Inflammatory mediators in plasma and the content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in RBC membranes were assessed.
Sixty-two patients (49.6%) developed POAF. The POAF group had higher RBC levels of total n-3 LC-PUFA and DHA than did patients remaining in sinus rhythm (p < 0.05). Of the inflammatory mediators, only postoperative interleukin-6 levels differed, being higher in the POAF group (p < 0.05). Inflammatory mediators were not independent predictors of POAF by multivariable logistic regression analysis. Higher levels of DHA and total n-3 LC-PUFA in RBC membranes, measured immediately prior to CABG and on postoperative day 3, were linearly associated with an increased risk of POAF (p < 0.05).
Our findings suggest that inflammatory mediators are not associated with the occurrence of POAF. Interestingly, high n-3 LC-PUFA levels in RBC membranes appear to increase the risk of POAF.
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Additional Links
http://dx.doi.org/10.1159/000351432
http://www.karger.com/Article/Pdf/351432
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Archived with thanks to Cardiology
ae974a485f413a2113503eed53cd6c53
10.1159/000351432
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English Journal Articles (Peer Reviewed)

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