Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids.
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Bjorgvinsdottir, LIndridason, O S
Heidarsdottir, R
Skogstrand, K
Arnar, D O
Torfason, B
Hougaard, D M
Palsson, R
Skuladottir, G V
Issue Date
2013-09
Metadata
Show full item recordCitation
Prostaglandins Leukot. Essent. Fatty Acids 2013, 89 (4):189-94Abstract
Open heart surgery is associated with a systemic inflammatory response. The n-3 long-chain polyunsaturated fatty acids (LC-PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and the n-6 LC-PUFA arachidonic acid (AA) may contribute to modulation of the inflammatory response.We investigated whether the preoperative levels of EPA, DHA and AA in plasma phospholipids (PL) and red blood cell (RBC) membrane lipids in patients (n=168) undergoing open heart surgery were associated with changes in the plasma concentration of selected inflammatory mediators in the immediate postoperative period.
The postoperative concentration of TNF-β was lower (P<0.05) and those of hs-CRP, IL-6, IL-8, IL-18 and IL-10 higher (P<0.05) than the respective preoperative concentrations. We observed that the preoperative levels of EPA and AA in plasma PL and RBC membrane lipids were associated with changes in the concentration of pro-inflammatory and anti-inflammatory mediators, suggesting a complex role in the postoperative inflammatory process.
Description
To access publisher's full text version of this article click on the hyperlink at the bottom of the pageAdditional Links
http://dx.doi.org/10.1016/j.plefa.2013.07.007http://ac.els-cdn.com/S0952327813001579/1-s2.0-S0952327813001579-main.pdf?_tid=4708f0f4-222c-11e4-b5ac-00000aacb35f&acdnat=1407853609_5dc339ee7a7a0cb1edbec315f969dff9
Rights
Archived with thanks to Prostaglandins, leukotrienes, and essential fatty acidsae974a485f413a2113503eed53cd6c53
10.1016/j.plefa.2013.07.007
Scopus Count
Collections
Related articles
- Do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation?
- Authors: Bjorgvinsdottir L, Arnar DO, Indridason OS, Heidarsdottir R, Skogstrand K, Torfason B, Hougaard DM, Palsson R, Skuladottir GV
- Issue date: 2013
- Randomized placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt: effects on circulating eicosanoids and cardiovascular risk factors.
- Authors: Dawczynski C, Massey KA, Ness C, Kiehntopf M, Stepanow S, Platzer M, Grün M, Nicolaou A, Jahreis G
- Issue date: 2013 Oct
- Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and α-linolenic acid conversion in preterm infants.
- Authors: Sauerwald UC, Fink MM, Demmelmair H, Schoenaich PV, Rauh-Pfeiffer AA, Koletzko B
- Issue date: 2012 Mar
- Plasma n-3 and n-6 fatty acids and the incidence of atrial fibrillation following coronary artery bypass graft surgery.
- Authors: Skuladottir GV, Heidarsdottir R, Arnar DO, Torfason B, Edvardsson V, Gottskalksson G, Palsson R, Indridason OS
- Issue date: 2011 Sep
- The Pattern of Fatty Acids Displaced by EPA and DHA Following 12 Months Supplementation Varies between Blood Cell and Plasma Fractions.
- Authors: Walker CG, West AL, Browning LM, Madden J, Gambell JM, Jebb SA, Calder PC
- Issue date: 2015 Aug 3