Seven new loci associated with age-related macular degeneration.

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Authors
Fritsche, Lars G
Chen, Wei
Schu, Matthew
Yaspan, Brian L
Yu, Yi
Thorleifsson, Gudmar
Zack, Donald J
Arakawa, Satoshi
Cipriani, Valentina
Ripke, Stephan
Igo, Robert P
Buitendijk, Gabriëlle H S
Sim, Xueling
Weeks, Daniel E
Guymer, Robyn H
Merriam, Joanna E
Francis, Peter J
Hannum, Gregory
Agarwal, Anita
Armbrecht, Ana Maria
Audo, Isabelle
Aung, Tin
Barile, Gaetano R
Benchaboune, Mustapha
Bird, Alan C
Bishop, Paul N
Branham, Kari E
Brooks, Matthew
Brucker, Alexander J
Cade, William H
Cain, Melinda S
Campochiaro, Peter A
Chan, Chi-Chao
Cheng, Ching-Yu
Chew, Emily Y
Chin, Kimberly A
Chowers, Itay
Clayton, David G
Cojocaru, Radu
Conley, Yvette P
Cornes, Belinda K
Daly, Mark J
Dhillon, Baljean
Edwards, Albert O
Evangelou, Evangelos
Fagerness, Jesen
Ferreyra, Henry A
Friedman, James S
Geirsdottir, Asbjorg
George, Ronnie J
Gieger, Christian
Gupta, Neel
Hagstrom, Stephanie A
Harding, Simon P
Haritoglou, Christos
Heckenlively, John R
Holz, Frank G
Hughes, Guy
Ioannidis, John P A
Ishibashi, Tatsuro
Joseph, Peronne
Jun, Gyungah
Kamatani, Yoichiro
Katsanis, Nicholas
N Keilhauer, Claudia
Khan, Jane C
Kim, Ivana K
Kiyohara, Yutaka
Klein, Barbara E K
Klein, Ronald
Kovach, Jaclyn L
Kozak, Igor
Lee, Clara J
Lee, Kristine E
Lichtner, Peter
Lotery, Andrew J
Meitinger, Thomas
Mitchell, Paul
Mohand-Saïd, Saddek
Moore, Anthony T
Morgan, Denise J
Morrison, Margaux A
Myers, Chelsea E
Naj, Adam C
Nakamura, Yusuke
Okada, Yukinori
Orlin, Anton
Ortube, M Carolina
Othman, Mohammad I
Pappas, Chris
Park, Kyu Hyung
Pauer, Gayle J T
Peachey, Neal S
Poch, Olivier
Priya, Rinki Ratna
Reynolds, Robyn
Richardson, Andrea J
Ripp, Raymond
Rudolph, Guenther
Ryu, Euijung
Sahel, José-Alain
Schaumberg, Debra A
Scholl, Hendrik P N
Schwartz, Stephen G
Scott, William K
Shahid, Humma
Sigurdsson, Haraldur
Silvestri, Giuliana
Sivakumaran, Theru A
Smith, R Theodore
Sobrin, Lucia
Souied, Eric H
Stambolian, Dwight E
Stefansson, Hreinn
Sturgill-Short, Gwen M
Takahashi, Atsushi
Tosakulwong, Nirubol
Truitt, Barbara J
Tsironi, Evangelia E
Uitterlinden, André G
van Duijn, Cornelia M
Vijaya, Lingam
Vingerling, Johannes R
Vithana, Eranga N
Webster, Andrew R
Wichmann, H-Erich
Winkler, Thomas W
Wong, Tien Y
Wright, Alan F
Zelenika, Diana
Zhang, Ming
Zhao, Ling
Zhang, Kang
Klein, Michael L
Hageman, Gregory S
Lathrop, G Mark
Stefansson, Kari
Allikmets, Rando
Baird, Paul N
Gorin, Michael B
Wang, Jie Jin
Klaver, Caroline C W
Seddon, Johanna M
Pericak-Vance, Margaret A
Iyengar, Sudha K
Yates, John R W
Swaroop, Anand
Weber, Bernhard H F
Kubo, Michiaki
Deangelis, Margaret M
Léveillard, Thierry
Thorsteinsdottir, Unnur
Haines, Jonathan L
Farrer, Lindsay A
Heid, Iris M
Abecasis, Gonçalo R
Issue Date
2013-04

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Citation
Nat. Genet. 2013, 45 (4):433-9, 439e1-2
Abstract
Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association study, including >17,100 advanced AMD cases and >60,000 controls of European and Asian ancestry. We identified 19 loci associated at P < 5 × 10(-8). These loci show enrichment for genes involved in the regulation of complement activity, lipid metabolism, extracellular matrix remodeling and angiogenesis. Our results include seven loci with associations reaching P < 5 × 10(-8) for the first time, near the genes COL8A1-FILIP1L, IER3-DDR1, SLC16A8, TGFBR1, RAD51B, ADAMTS9 and B3GALTL. A genetic risk score combining SNP genotypes from all loci showed similar ability to distinguish cases and controls in all samples examined. Our findings provide new directions for biological, genetic and therapeutic studies of AMD.
Additional Links
http://dx.doi.org/10.1038/ng.2578
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739472/
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