Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Fritsche, Lars GChen, Wei
Schu, Matthew
Yaspan, Brian L
Yu, Yi
Thorleifsson, Gudmar
Zack, Donald J
Arakawa, Satoshi
Cipriani, Valentina
Ripke, Stephan
Igo, Robert P
Buitendijk, Gabriëlle H S
Sim, Xueling
Weeks, Daniel E
Guymer, Robyn H
Merriam, Joanna E
Francis, Peter J
Hannum, Gregory
Agarwal, Anita
Armbrecht, Ana Maria
Audo, Isabelle
Aung, Tin
Barile, Gaetano R
Benchaboune, Mustapha
Bird, Alan C
Bishop, Paul N
Branham, Kari E
Brooks, Matthew
Brucker, Alexander J
Cade, William H
Cain, Melinda S
Campochiaro, Peter A
Chan, Chi-Chao
Cheng, Ching-Yu
Chew, Emily Y
Chin, Kimberly A
Chowers, Itay
Clayton, David G
Cojocaru, Radu
Conley, Yvette P
Cornes, Belinda K
Daly, Mark J
Dhillon, Baljean
Edwards, Albert O
Evangelou, Evangelos
Fagerness, Jesen
Ferreyra, Henry A
Friedman, James S
Geirsdottir, Asbjorg
George, Ronnie J
Gieger, Christian
Gupta, Neel
Hagstrom, Stephanie A
Harding, Simon P
Haritoglou, Christos
Heckenlively, John R
Holz, Frank G
Hughes, Guy
Ioannidis, John P A
Ishibashi, Tatsuro
Joseph, Peronne
Jun, Gyungah
Kamatani, Yoichiro
Katsanis, Nicholas
N Keilhauer, Claudia
Khan, Jane C
Kim, Ivana K
Kiyohara, Yutaka
Klein, Barbara E K
Klein, Ronald
Kovach, Jaclyn L
Kozak, Igor
Lee, Clara J
Lee, Kristine E
Lichtner, Peter
Lotery, Andrew J
Meitinger, Thomas
Mitchell, Paul
Mohand-Saïd, Saddek
Moore, Anthony T
Morgan, Denise J
Morrison, Margaux A
Myers, Chelsea E
Naj, Adam C
Nakamura, Yusuke
Okada, Yukinori
Orlin, Anton
Ortube, M Carolina
Othman, Mohammad I
Pappas, Chris
Park, Kyu Hyung
Pauer, Gayle J T
Peachey, Neal S
Poch, Olivier
Priya, Rinki Ratna
Reynolds, Robyn
Richardson, Andrea J
Ripp, Raymond
Rudolph, Guenther
Ryu, Euijung
Sahel, José-Alain
Schaumberg, Debra A
Scholl, Hendrik P N
Schwartz, Stephen G
Scott, William K
Shahid, Humma
Sigurdsson, Haraldur
Silvestri, Giuliana
Sivakumaran, Theru A
Smith, R Theodore
Sobrin, Lucia
Souied, Eric H
Stambolian, Dwight E
Stefansson, Hreinn
Sturgill-Short, Gwen M
Takahashi, Atsushi
Tosakulwong, Nirubol
Truitt, Barbara J
Tsironi, Evangelia E
Uitterlinden, André G
van Duijn, Cornelia M
Vijaya, Lingam
Vingerling, Johannes R
Vithana, Eranga N
Webster, Andrew R
Wichmann, H-Erich
Winkler, Thomas W
Wong, Tien Y
Wright, Alan F
Zelenika, Diana
Zhang, Ming
Zhao, Ling
Zhang, Kang
Klein, Michael L
Hageman, Gregory S
Lathrop, G Mark
Stefansson, Kari
Allikmets, Rando
Baird, Paul N
Gorin, Michael B
Wang, Jie Jin
Klaver, Caroline C W
Seddon, Johanna M
Pericak-Vance, Margaret A
Iyengar, Sudha K
Yates, John R W
Swaroop, Anand
Weber, Bernhard H F
Kubo, Michiaki
Deangelis, Margaret M
Léveillard, Thierry
Thorsteinsdottir, Unnur
Haines, Jonathan L
Farrer, Lindsay A
Heid, Iris M
Abecasis, Gonçalo R
Issue Date
2013-04
Metadata
Show full item recordCitation
Nat. Genet. 2013, 45 (4):433-9, 439e1-2Abstract
Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association study, including >17,100 advanced AMD cases and >60,000 controls of European and Asian ancestry. We identified 19 loci associated at P < 5 × 10(-8). These loci show enrichment for genes involved in the regulation of complement activity, lipid metabolism, extracellular matrix remodeling and angiogenesis. Our results include seven loci with associations reaching P < 5 × 10(-8) for the first time, near the genes COL8A1-FILIP1L, IER3-DDR1, SLC16A8, TGFBR1, RAD51B, ADAMTS9 and B3GALTL. A genetic risk score combining SNP genotypes from all loci showed similar ability to distinguish cases and controls in all samples examined. Our findings provide new directions for biological, genetic and therapeutic studies of AMD.Additional Links
http://dx.doi.org/10.1038/ng.2578http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739472/
Rights
Archived with thanks to Nature geneticsae974a485f413a2113503eed53cd6c53
10.1038/ng.2578
Scopus Count
Collections
Related articles
- Genome-wide meta-analysis identifies novel loci associated with age-related macular degeneration.
- Authors: Han X, Gharahkhani P, Mitchell P, Liew G, Hewitt AW, MacGregor S
- Issue date: 2020 Aug
- Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
- Authors: Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL, Complications of Age-Related Macular Degeneration Prevention Trial Research Group., Brucker AJ, Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Cortón M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A
- Issue date: 2010 Apr 20
- Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study.
- Authors: Ryu E, Fridley BL, Tosakulwong N, Bailey KR, Edwards AO
- Issue date: 2010 Dec 17
- Shared genetic variants for polypoidal choroidal vasculopathy and typical neovascular age-related macular degeneration in East Asians.
- Authors: Fan Q, Cheung CMG, Chen LJ, Yamashiro K, Ahn J, Laude A, Mathur R, Mun CC, Yeo IY, Lim TH, Teo YY, Khor CC, Park KH, Yoshimura N, Pang CP, Wong TY, Cheng CY
- Issue date: 2017 Dec
- New loci and coding variants confer risk for age-related macular degeneration in East Asians.
- Authors: Cheng CY, Yamashiro K, Chen LJ, Ahn J, Huang L, Huang L, Cheung CM, Miyake M, Cackett PD, Yeo IY, Laude A, Mathur R, Pang J, Sim KS, Koh AH, Chen P, Lee SY, Wong D, Chan CM, Loh BK, Sun Y, Davila S, Nakata I, Nakanishi H, Akagi-Kurashige Y, Gotoh N, Tsujikawa A, Matsuda F, Mori K, Yoneya S, Sakurada Y, Iijima H, Iida T, Honda S, Lai TY, Tam PO, Chen H, Tang S, Ding X, Wen F, Lu F, Zhang X, Shi Y, Zhao P, Zhao B, Sang J, Gong B, Dorajoo R, Yuan JM, Koh WP, van Dam RM, Friedlander Y, Lin Y, Hibberd ML, Foo JN, Wang N, Wong CH, Tan GS, Park SJ, Bhargava M, Gopal L, Naing T, Liao J, Ong PG, Mitchell P, Zhou P, Xie X, Liang J, Mei J, Jin X, Saw SM, Ozaki M, Mizoguchi T, Kurimoto Y, Woo SJ, Chung H, Yu HG, Shin JY, Park DH, Kim IT, Chang W, Sagong M, Lee SJ, Kim HW, Lee JE, Li Y, Liu J, Teo YY, Heng CK, Lim TH, Yang SK, Song K, Vithana EN, Aung T, Bei JX, Zeng YX, Tai ES, Li XX, Yang Z, Park KH, Pang CP, Yoshimura N, Wong TY, Khor CC
- Issue date: 2015 Jan 28