Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome -- a randomized study (SYSDIET).
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Uusitupa, MHermansen, K
Savolainen, M J
Schwab, U
Kolehmainen, M
Brader, L
Mortensen, L S
Cloetens, L
Johansson-Persson, A
Onning, G
Landin-Olsson, M
Herzig, K-H
Hukkanen, J
Rosqvist, F
Iggman, D
Paananen, J
Pulkki, K J
Siloaho, M
Dragsted, L
Barri, T
Overvad, K
Bach Knudsen, K E
Hedemann, M S
Arner, P
Dahlman, I
Borge, G I A
Baardseth, P
Ulven, S M
Gunnarsdottir, I
Jónsdóttir, S
Thorsdottir, I
Orešič, M
Poutanen, K S
Risérus, U
Akesson, B
Issue Date
2013-07
Metadata
Show full item recordCitation
J. Intern. Med. 2013, 274 (1):52-66Abstract
Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome.We conducted a randomized dietary study lasting for 18-24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m(-2) , 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids.
Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmol L(-1) 95% CI -0.35; -0.01, P = 0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P = 0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37 ng L(-1) , P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, -0.23, -0.41; -0.05, P = 0.012) were associated with IL-1 Ra.
Healthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.
Description
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.Additional Links
http://dx.doi.org/10.1111/joim.12044http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749468/
Rights
openAccessae974a485f413a2113503eed53cd6c53
10.1111/joim.12044
Scopus Count
Collections
Related articles
- A dietary biomarker approach captures compliance and cardiometabolic effects of a healthy Nordic diet in individuals with metabolic syndrome.
- Authors: Marklund M, Magnusdottir OK, Rosqvist F, Cloetens L, Landberg R, Kolehmainen M, Brader L, Hermansen K, Poutanen KS, Herzig KH, Hukkanen J, Savolainen MJ, Dragsted LO, Schwab U, Paananen J, Uusitupa M, Åkesson B, Thorsdottir I, Risérus U
- Issue date: 2014 Oct
- Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome--a randomized study.
- Authors: Magnusdottir OK, Landberg R, Gunnarsdottir I, Cloetens L, Åkesson B, Rosqvist F, Schwab U, Herzig KH, Hukkanen J, Savolainen MJ, Brader L, Hermansen K, Kolehmainen M, Poutanen K, Uusitupa M, Risérus U, Thorsdottir I
- Issue date: 2014
- Associations between school meal-induced dietary changes and metabolic syndrome markers in 8-11-year-old Danish children.
- Authors: Damsgaard CT, Ritz C, Dalskov SM, Landberg R, Stark KD, Biltoft-Jensen A, Tetens I, Astrup A, Michaelsen KF, Lauritzen L
- Issue date: 2016 Aug
- A whole-grain cereal-based diet lowers postprandial plasma insulin and triglyceride levels in individuals with metabolic syndrome.
- Authors: Giacco R, Costabile G, Della Pepa G, Anniballi G, Griffo E, Mangione A, Cipriano P, Viscovo D, Clemente G, Landberg R, Pacini G, Rivellese AA, Riccardi G
- Issue date: 2014 Aug
- Effects of an isocaloric healthy Nordic diet on ambulatory blood pressure in metabolic syndrome: a randomized SYSDIET sub-study.
- Authors: Brader L, Uusitupa M, Dragsted LO, Hermansen K
- Issue date: 2014 Jan