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dc.contributor.authorUusitupa, M
dc.contributor.authorHermansen, K
dc.contributor.authorSavolainen, M J
dc.contributor.authorSchwab, U
dc.contributor.authorKolehmainen, M
dc.contributor.authorBrader, L
dc.contributor.authorMortensen, L S
dc.contributor.authorCloetens, L
dc.contributor.authorJohansson-Persson, A
dc.contributor.authorOnning, G
dc.contributor.authorLandin-Olsson, M
dc.contributor.authorHerzig, K-H
dc.contributor.authorHukkanen, J
dc.contributor.authorRosqvist, F
dc.contributor.authorIggman, D
dc.contributor.authorPaananen, J
dc.contributor.authorPulkki, K J
dc.contributor.authorSiloaho, M
dc.contributor.authorDragsted, L
dc.contributor.authorBarri, T
dc.contributor.authorOvervad, K
dc.contributor.authorBach Knudsen, K E
dc.contributor.authorHedemann, M S
dc.contributor.authorArner, P
dc.contributor.authorDahlman, I
dc.contributor.authorBorge, G I A
dc.contributor.authorBaardseth, P
dc.contributor.authorUlven, S M
dc.contributor.authorGunnarsdottir, I
dc.contributor.authorJónsdóttir, S
dc.contributor.authorThorsdottir, I
dc.contributor.authorOrešič, M
dc.contributor.authorPoutanen, K S
dc.contributor.authorRisérus, U
dc.contributor.authorAkesson, B
dc.date.accessioned2014-08-14T10:03:11Z
dc.date.available2014-08-14T10:03:11Z
dc.date.issued2013-07
dc.date.submitted2013
dc.identifier.citationJ. Intern. Med. 2013, 274 (1):52-66en
dc.identifier.issn1365-2796
dc.identifier.pmid23398528
dc.identifier.doi10.1111/joim.12044
dc.identifier.urihttp://hdl.handle.net/2336/324778
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.en
dc.description.abstractDifferent healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome.
dc.description.abstractWe conducted a randomized dietary study lasting for 18-24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m(-2) , 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids.
dc.description.abstractBody weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmol L(-1) 95% CI -0.35; -0.01, P = 0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P = 0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37 ng L(-1) , P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, -0.23, -0.41; -0.05, P = 0.012) were associated with IL-1 Ra.
dc.description.abstractHealthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.
dc.description.sponsorshipNordForsk Academy of Finland Finnish Diabetes Research Foundation Finnish Foundation for Cardiovascular Research Sigfrid Juselius Foundation Kuopio University Hospital (Finland) Druvan Foundation ESPEN Skane County Council Research and Development Foundationl Heart-Lung Foundation Diabetesfonden Foundation Cerealia (Sweden) Danish Obesity Research Centre (DanORC) Danish Council for Strategic Research (Dairy-Health, BioFunCarb) (Denmark) Agricultural Productivity Fund University of Iceland (Iceland)en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://dx.doi.org/10.1111/joim.12044en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749468/en
dc.rightsopenAccessen
dc.subjectMataræðien
dc.subjectBlóðfitaen
dc.subjectBlóðþrýstinguren
dc.subjectInsúlínen
dc.subjectOrkaen
dc.subjectBólguren
dc.subject.meshApolipoproteins Aen
dc.subject.meshApolipoproteins Ben
dc.subject.meshBiological Markersen
dc.subject.meshBlood Glucoseen
dc.subject.meshBlood Pressureen
dc.subject.meshCholesterol, HDLen
dc.subject.meshCholesterol, LDLen
dc.subject.meshDenmarken
dc.subject.meshDieten
dc.subject.meshEnergy Intakeen
dc.subject.meshFatty Acidsen
dc.subject.meshFinlanden
dc.subject.meshGlucose Tolerance Testen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshInflammationen
dc.subject.meshInsulin Resistanceen
dc.subject.meshInterleukin 1 Receptor Antagonist Proteinen
dc.subject.meshLipidsen
dc.subject.meshMaleen
dc.subject.meshMetabolic Syndrome Xen
dc.subject.meshMiddle Ageden
dc.subject.meshSwedenen
dc.subject.meshTreatment Outcomeen
dc.titleEffects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome -- a randomized study (SYSDIET).en
dc.typeArticleen
dc.contributor.department[ 1 ] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland [ 2 ] Kuopio Univ Hosp, Res Unit, SF-70210 Kuopio, Finland [ 3 ] Aarhus Univ Hosp, Dept Med & Endocrinol MEA, DK-8000 Aarhus, Denmark [ 4 ] Univ Oulu, Dept Internal Med, Inst Clin Med, SF-90220 Oulu, Finland [ 5 ] Kuopio Univ Hosp, Inst Clin Med, SF-70210 Kuopio, Finland [ 6 ] Lund Univ, Lund, Sweden [ 7 ] Skane Univ Hosp, Dept Endocrinol, Lund, Sweden [ 8 ] Univ Oulu, Inst Biomed, Oulu, Finland [ 9 ] Univ Oulu, Bioctr Oulu, Oulu, Finland [ 10 ] Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland [ 11 ] Uppsala Univ, Dept Publ Hlth & Caring Sci, Uppsala, Sweden [ 12 ] Ctr Clin Res Dalarna, Falun, Sweden [ 13 ] Univ Eastern Finland, Eastern Finland Lab Ctr, Kuopio 70211, Finland [ 14 ] Univ Eastern Finland, Dept Clin Chem, Kuopio 70211, Finland [ 15 ] Univ Eastern Finland, Inst Clin Med, Kuopio 70211, Finland [ 16 ] Univ Copenhagen, Dept Nutr Exercise & Sport, Copenhagen, Denmark [ 17 ] Aarhus Univ, Dept Epidemiol, Sch Publ Hlth, Aarhus, Denmark [ 18 ] Aarhus Univ Hosp, Aalborg Hosp, Dept Cardiol, DK-8000 Aarhus, Denmark [ 19 ] Aarhus Univ, Dept Anim Sci, Aarhus, Denmark [ 20 ] Karolinska Inst, Dept Med H7, Stockholm, Sweden [ 21 ] Norwegian Inst Food Fisheries & Aquaculture Res, Nofima, As, Norway [ 22 ] Fac Hlth Sci, Dept Hlth Nutr & Management, Oslo, Norway [ 23 ] Akershus Univ Coll Appl Sci, Oslo, Norway [ 24 ] Univ Iceland, Unit Nutr Res, Reykjavik, Iceland [ 25 ] Natl Univ Hosp Iceland, Landspitali, Reykjavik, Iceland [ 26 ] VTT Tech Res Ctr Finland, Espoo, Finland [ 27 ] Skane Univ Hosp, Dept Clin Nutr, Lund, Swedenen
dc.identifier.journalJournal of internal medicineen
dc.rights.accessOpen Accessen
refterms.dateFOA2018-09-12T13:30:19Z
html.description.abstractDifferent healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome.
html.description.abstractWe conducted a randomized dietary study lasting for 18-24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m(-2) , 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids.
html.description.abstractBody weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmol L(-1) 95% CI -0.35; -0.01, P = 0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P = 0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37 ng L(-1) , P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, -0.23, -0.41; -0.05, P = 0.012) were associated with IL-1 Ra.
html.description.abstractHealthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.


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