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dc.contributor.authorBønnelykke, Klaus
dc.contributor.authorMatheson, Melanie C
dc.contributor.authorPers, Tune H
dc.contributor.authorGranell, Raquel
dc.contributor.authorStrachan, David P
dc.contributor.authorAlves, Alexessander Couto
dc.contributor.authorLinneberg, Allan
dc.contributor.authorCurtin, John A
dc.contributor.authorWarrington, Nicole M
dc.contributor.authorStandl, Marie
dc.contributor.authorKerkhof, Marjan
dc.contributor.authorJonsdottir, Ingileif
dc.contributor.authorBukvic, Blazenka K
dc.contributor.authorKaakinen, Marika
dc.contributor.authorSleimann, Patrick
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorSchramm, Katharina
dc.contributor.authorBaltic, Svetlana
dc.contributor.authorKreiner-Møller, Eskil
dc.contributor.authorSimpson, Angela
dc.contributor.authorSt Pourcain, Beate
dc.contributor.authorCoin, Lachlan
dc.contributor.authorHui, Jennie
dc.contributor.authorWalters, Eugene H
dc.contributor.authorTiesler, Carla M T
dc.contributor.authorDuffy, David L
dc.contributor.authorJones, Graham
dc.contributor.authorRing, Susan M
dc.contributor.authorMcArdle, Wendy L
dc.contributor.authorPrice, Loren
dc.contributor.authorRobertson, Colin F
dc.contributor.authorPekkanen, Juha
dc.contributor.authorTang, Clara S
dc.contributor.authorThiering, Elisabeth
dc.contributor.authorMontgomery, Grant W
dc.contributor.authorHartikainen, Anna-Liisa
dc.contributor.authorDharmage, Shyamali C
dc.contributor.authorHusemoen, Lise L
dc.contributor.authorHerder, Christian
dc.contributor.authorKemp, John P
dc.contributor.authorElliot, Paul
dc.contributor.authorJames, Alan
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorAbramson, Michael J
dc.contributor.authorFairfax, Benjamin P
dc.contributor.authorKnight, Julian C
dc.contributor.authorGupta, Ramneek
dc.contributor.authorThompson, Philip J
dc.contributor.authorHolt, Patrick
dc.contributor.authorSly, Peter
dc.contributor.authorHirschhorn, Joel N
dc.contributor.authorBlekic, Mario
dc.contributor.authorWeidinger, Stephan
dc.contributor.authorHakonarsson, Hakon
dc.contributor.authorStefansson, Kari
dc.contributor.authorHeinrich, Joachim
dc.contributor.authorPostma, Dirkje S
dc.contributor.authorCustovic, Adnan
dc.contributor.authorPennell, Craig E
dc.contributor.authorJarvelin, Marjo-Riitta
dc.contributor.authorKoppelman, Gerard H
dc.contributor.authorTimpson, Nicholas
dc.contributor.authorFerreira, Manuel A
dc.contributor.authorBisgaard, Hans
dc.contributor.authorHenderson, A John
dc.date.accessioned2014-08-19T11:46:38Z
dc.date.available2014-08-19T11:46:38Z
dc.date.issued2013-08
dc.identifier.citationMeta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. 2013, 45 (8):902-6 Nat. Genet.en
dc.identifier.issn1546-1718
dc.identifier.pmid23817571
dc.identifier.doi10.1038/ng.2694
dc.identifier.urihttp://hdl.handle.net/2336/324983
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractAllergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urlhttp://dx.doi.org/10.1038/ng.2694en
dc.relation.urlhttp://www.nature.com/ng/journal/v45/n8/pdf/ng.2694.pdfen
dc.rightsArchived with thanks to Nature geneticsen
dc.subjectArfgengien
dc.subjectOfnæmien
dc.subject.meshAllelesen
dc.subject.meshComputational Biologyen
dc.subject.meshGene Regulatory Networksen
dc.subject.meshGenetic Locien
dc.subject.meshGenome-Wide Association Studyen
dc.subject.meshGenomicsen
dc.subject.meshHumansen
dc.subject.meshHypersensitivityen
dc.subject.meshPhenotypeen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshQuantitative Trait Locien
dc.subject.meshSignal Transductionen
dc.titleMeta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.en
dc.typeArticleen
dc.contributor.department[ 1 ] Univ Copenhagen, COPSAC Copenhagen Prospect Studies Asthma Childho, Gentofte, Denmark Show the Organization-Enhanced name(s) [ 2 ] Copenhagen Univ Hosp, Gentofte, Denmark Show the Organization-Enhanced name(s) [ 3 ] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia Show the Organization-Enhanced name(s) [ 4 ] Tech Univ Denmark, Ctr Biol Sequence Anal, DK-2800 Lyngby, Denmark Show the Organization-Enhanced name(s) [ 5 ] Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA Show the Organization-Enhanced name(s) [ 6 ] Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA 02115 USA Show the Organization-Enhanced name(s) [ 7 ] Broad Inst, Cambridge, MA USA Show the Organization-Enhanced name(s) [ 8 ] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England Show the Organization-Enhanced name(s) [ 9 ] Univ London, Div Populat Hlth Sci & Educ, London, England Show the Organization-Enhanced name(s) [ 10 ] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England Show the Organization-Enhanced name(s) [ 11 ] Glostrup Cty Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark Show the Organization-Enhanced name(s) [ 12 ] Univ Manchester, Univ Hosp South Manchester Natl Hlth Serv NHS Fdn, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England Show the Organization-Enhanced name(s) [ 13 ] Univ Western Australia, Sch Womens & Infants Hlth, Crawley, WA, Australia Show the Organization-Enhanced name(s) [ 14 ] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany Show the Organization-Enhanced name(s) [ 15 ] Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma & COPD GRIAC, Dept Epidemiol, Groningen, Netherlands [ 16 ] deCODE Genet, Reykjavik, Iceland Show the Organization-Enhanced name(s) [ 17 ] Univ Iceland, Reykjavik, Iceland Show the Organization-Enhanced name(s) [ 18 ] Univ Osijek, Gen Hosp Dr Josip Bencev Slavonski Brod, Dept Pediat, Osijek, Croatia Show the Organization-Enhanced name(s) [ 19 ] Univ Oulu, Inst Hlth Sci, Oulu, Finland Show the Organization-Enhanced name(s) [ 20 ] Univ Oulu, Bioctr Oulu, Oulu, Finland Show the Organization-Enhanced name(s) [ 21 ] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Ctr Appl Genom, Philadelphia, PA 19104 USA Show the Organization-Enhanced name(s) [ 22 ] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Div Human Genet, Philadelphia, PA 19104 USA Show the Organization-Enhanced name(s) [ 23 ] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Human Genet, Neuherberg, Germany Show the Organization-Enhanced name(s) [ 24 ] Univ Western Australia, Lung Inst Western Australia, Perth, WA 6009, Australia Show the Organization-Enhanced name(s) [ 25 ] Univ Western Australia, Ctr Asthma Allergy & Resp Res, Perth, WA 6009, Australia [ 26 ] PathWest Lab Med Western Australia, Nedlands, WA, Australia Show the Organization-Enhanced name(s) [ 27 ] Univ Western Australia, Sch Populat Hlth, Nedlands, WA 6009, Australia Show the Organization-Enhanced name(s) [ 28 ] Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia [ 29 ] Sir Charles Gairdner Hosp, Busselton Populat Med Res Fdn, Perth, WA, Australia Show the Organization-Enhanced name(s) [ 30 ] Univ Tasmania, Sch Med, Hobart, Tas, Australia Show the Organization-Enhanced name(s) [ 31 ] Queensland Inst Med Res, Brisbane, Qld 4006, Australia Show the Organization-Enhanced name(s) [ 32 ] Univ Western Sydney, Sch Sci & Hlth, Penrith, NSW 1797, Australia Show the Organization-Enhanced name(s) [ 33 ] Murdoch Childrens Res Inst, Melbourne, Vic, Australia [ 34 ] Natl Inst Hlth & Welf THL, Dept Environm Hlth, Kuopio, Finland Show the Organization-Enhanced name(s) [ 35 ] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland Show the Organization-Enhanced name(s) [ 36 ] Univ Oulu, Inst Clin Med, Dept Clin Sci Obstet & Gynecol, Oulu, Finland Show the Organization-Enhanced name(s) [ 37 ] Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, D-40225 Dusseldorf, Germany Show the Organization-Enhanced name(s) [ 38 ] Univ Western Australia, Sch Med & Pharmacol, Nedlands, WA 6009, Australia [ 39 ] West Australian Sleep Disorders Res Inst, Dept Pulm Physiol, Nedlands, WA, Australia Show the Organization-Enhanced name(s) [ 40 ] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany Show the Organization-Enhanced name(s) [ 41 ] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia Show the Organization-Enhanced name(s) [ 42 ] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England Show the Organization-Enhanced name(s) [ 43 ] Univ Western Australia, Telethon Inst Child Hlth Res, Perth, WA 6009, Australia Show the Organization-Enhanced name(s) [ 44 ] Univ Western Australia, Ctr Child Hlth Res, Perth, WA 6009, Australia Show the Organization-Enhanced name(s) [ 45 ] Univ Queensland, Queensland Childrens Med Res Inst, WHO Collaborating Ctr Res Childrens Environm Hlth, Brisbane, Qld, Australia Show the Organization-Enhanced name(s) [ 46 ] Childrens Hosp, Div Genet, Boston, MA 02115 USA Show the Organization-Enhanced name(s) [ 47 ] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA Show the Organization-Enhanced name(s) [ 48 ] Univ Hosp Schleswig Holstein, Dept Dermatol Allergol & Venerol, Kiel, Germany Show the Organization-Enhanced name(s) [ 49 ] Univ Groningen, Univ Med Ctr Groningen, GRIAC, Dept Pulmonol, Groningen, Netherlands Show the Organization-Enhanced name(s) [ 50 ] Univ London Imperial Coll Sci Technol & Med, MRC HPA Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England [ 51 ] Natl Inst Hlth & Welf, Oulu, Finland [ 52 ] Oulu Univ Hosp, Unit Primary Care, Oulu, Finland Show the Organization-Enhanced name(s) [ 53 ] Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp,GRIAC, Dept Pediat Pulmonol & Pediat Allergol, Groningen, Netherlandsen
dc.identifier.journalNature geneticsen
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractAllergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.


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