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dc.contributor.authorBurisch, J
dc.contributor.authorPedersen, N
dc.contributor.authorČuković-Čavka, S
dc.contributor.authorBrinar, M
dc.contributor.authorKaimakliotis, I
dc.contributor.authorDuricova, D
dc.contributor.authorShonová, O
dc.contributor.authorVind, I
dc.contributor.authorAvnstrøm, S
dc.contributor.authorThorsgaard, N
dc.contributor.authorAndersen, V
dc.contributor.authorKrabbe, S
dc.contributor.authorDahlerup, J F
dc.contributor.authorSalupere, R
dc.contributor.authorNielsen, K R
dc.contributor.authorOlsen, J
dc.contributor.authorManninen, P
dc.contributor.authorCollin, P
dc.contributor.authorTsianos, E V
dc.contributor.authorKatsanos, K H
dc.contributor.authorLadefoged, K
dc.contributor.authorLakatos, L
dc.contributor.authorBjörnsson, E
dc.contributor.authorRagnarsson, G
dc.contributor.authorBailey, Y
dc.contributor.authorOdes, S
dc.contributor.authorSchwartz, D
dc.contributor.authorMartinato, M
dc.contributor.authorLupinacci, G
dc.contributor.authorMilla, M
dc.contributor.authorDe Padova, A
dc.contributor.authorD'Incà, R
dc.contributor.authorBeltrami, M
dc.contributor.authorKupcinskas, L
dc.contributor.authorKiudelis, G
dc.contributor.authorTurcan, S
dc.contributor.authorTighineanu, O
dc.contributor.authorMihu, I
dc.contributor.authorMagro, F
dc.contributor.authorBarros, L F
dc.contributor.authorGoldis, A
dc.contributor.authorLazar, D
dc.contributor.authorBelousova, E
dc.contributor.authorNikulina, I
dc.contributor.authorHernandez, V
dc.contributor.authorMartinez-Ares, D
dc.contributor.authorAlmer, S
dc.contributor.authorZhulina, Y
dc.contributor.authorHalfvarson, J
dc.contributor.authorArebi, N
dc.contributor.authorSebastian, S
dc.contributor.authorLakatos, P L
dc.contributor.authorLangholz, E
dc.contributor.authorMunkholm, P
dc.date.accessioned2014-08-25T14:24:44Z
dc.date.available2014-08-25T14:24:44Z
dc.date.issued2014-04
dc.date.submitted2014
dc.identifier.citationGut 2014, 63 (4):588-97en
dc.identifier.issn1468-3288
dc.identifier.pmid23604131
dc.identifier.doi10.1136/gutjnl-2013-304636
dc.identifier.urihttp://hdl.handle.net/2336/325171
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.en
dc.description.abstractThe incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe. The reasons for these changes remain unknown. The aim of this study was to investigate whether an East-West gradient in the incidence of IBD in Europe exists.
dc.description.abstractA prospective, uniformly diagnosed, population based inception cohort of IBD patients in 31 centres from 14 Western and eight Eastern European countries covering a total background population of approximately 10.1 million people was created. One-third of the centres had previous experience with inception cohorts. Patients were entered into a low cost, web based epidemiological database, making participation possible regardless of socioeconomic status and prior experience.
dc.description.abstract1515 patients aged 15 years or older were included, of whom 535 (35%) were diagnosed with Crohn's disease (CD), 813 (54%) with ulcerative colitis (UC) and 167 (11%) with IBD unclassified (IBDU). The overall incidence rate ratios in all Western European centres were 1.9 (95% CI 1.5 to 2.4) for CD and 2.1 (95% CI 1.8 to 2.6) for UC compared with Eastern European centres. The median crude annual incidence rates per 100,000 in 2010 for CD were 6.5 (range 0-10.7) in Western European centres and 3.1 (range 0.4-11.5) in Eastern European centres, for UC 10.8 (range 2.9-31.5) and 4.1 (range 2.4-10.3), respectively, and for IBDU 1.9 (range 0-39.4) and 0 (range 0-1.2), respectively. In Western Europe, 92% of CD, 78% of UC and 74% of IBDU patients had a colonoscopy performed as the diagnostic procedure compared with 90%, 100% and 96%, respectively, in Eastern Europe. 8% of CD and 1% of UC patients in both regions underwent surgery within the first 3 months of the onset of disease. 7% of CD patients and 3% of UC patients from Western Europe received biological treatment as rescue therapy. Of all European CD patients, 20% received only 5-aminosalicylates as induction therapy.
dc.description.abstractAn East-West gradient in IBD incidence exists in Europe. Among this inception cohort--including indolent and aggressive cases--international guidelines for diagnosis and initial treatment are not being followed uniformly by physicians.
dc.description.sponsorshipDanish Colitis Crohn Patients Organisation (CCF) Vibeke Binder and Povl Riis' Foundation Scientific Council at Herlev Hospital Sigrid Rigmor Moran Foundation Aage and Johanne Louis-Hansens Foundation Munkholm Foundation CC Klestrup and Henriette Klestrup Foundation Knud and Dagny Gad Andresens Foundation Else and Mogens Wedell-Wedellsborgs Foundation Direktor Jacob Madsen Foundation Olga Madsens Foundation ScanVet Torben og Alice Frimodt Foundation Bengt Ihre's Foundation Nanna Svartz' Foundation Orebro University Hospital Research Foundation Orebro County Research Foundation Swedish Foundation for Gastrointestinal Research Swedish Research Council Swedish Society of Medicine Research Council of South-East Sweden County Council of Ostergotland Swedish Organization for the study of inflammatory bowel disease European Crohn's and Colitis Organisation's (ECCO)en
dc.language.isoenen
dc.publisherBmj Publishing Groupen
dc.relation.urlhttp://dx.doi.org/10.1136/gutjnl-2013-304636en
dc.relation.urlhttp://gut.bmj.com/content/63/4/588.full.pdf+htmlen
dc.rightsopenAccessen
dc.subjectCrohns-sjúkdómuren
dc.subjectIðraólgaen
dc.subjectRistilspeglunen
dc.subjectTíðnien
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshColitis, Ulcerativeen
dc.subject.meshColonoscopyen
dc.subject.meshCrohn Diseaseen
dc.subject.meshEuropeen
dc.subject.meshEurope, Easternen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIncidenceen
dc.subject.meshInflammatory Bowel Diseasesen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshProspective Studiesen
dc.subject.meshYoung Adulten
dc.titleEast-West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort.en
dc.typeArticleen
dc.contributor.departmentHerlev Univ Hosp, Ctr Digest Dis, Med Sect, DK-2730 Copenhagen, Denmark, Univ Zagreb, Sch Med, Univ Hosp Ctr Zagreb, Div Gastroenterol & Hepatol, Zagreb 41000, Croatia, Nicosia Private Practice, Nicosia, Cyprus, Charles Univ Prague, IBD Ctr ISCARE, Prague, Czech Republic, Hosp Ceske Budejovice, Dept Gastroenterol, Ceske Budejovice, Czech Republic, Amager Hosp, Dept Med, Amager, Denmark, Herning Cent Hosp, Dept Med, Herning, Denmark, Viborg Reg Hosp, Dept Med, Viborg, Denmark, Hosp Southern Jutland, Dept Med, Aabenraa, Denmark, Univ Southern Denmark, Odense, Denmark, Aarhus Univ Hosp, Dept Med Hepatol & Gastroenterol 5, Aarhus, Denmark, Tartu Univ Hosp, Div Endocrinol & Gastroenterol, Tartu, Estonia, Natl Hosp Faroe Isl, Med Dept, Torshavn, Faroe Islands, Denmark, Tampere Univ Hosp, Dept Gastroenterol & Alimentary Tract Surg, Tampere, Finland, Univ Hosp, Div Internal Med 1, Ioannina, Greece, Univ Hosp, Hepato Gastroenterol Unit, Ioannina, Greece, Dronning Ingrids Hosp, Dept Med, Nuuk, Greenland, Natl Univ Hosp Reykjavik, Sect Gastroenterol & Hepatol, Dept Internal Med, Reykjavik, Iceland, ACD, Adelaide & Meath Hosp, Dept Gastroenterol, Dublin, Ireland, Ben Gurion Univ Negev, Dept Gastroenterol & Hepatol, Soroka Med Ctr, IL-84105 Beer Sheva, Israel, Ben Gurion Univ Negev, IL-84105 Beer Sheva, Israel, Univ Padua, UO Gastroenterol, Azienda Osped, Padua, Italy, Az Osped Osped Cremona, UO Med Gastroenterol, Cremona, Italy, UO Gastroenterol Endoscopia Digest, Az Osped Osped Maggiore Crema, Crema, Italy, Careggi Hosp, Gastroenterol Unit, Florence, Italy, Osped Morgagni Pierantoni, UO Gastroenterol Endoscopia Digest, Forli, Italy, Azienda Osped Arcispedale S Maria Nuova, UO Med & Gastroenterol 3, Reggio Emilia, Italy, Lithuanian Univ Hlth Sci, Inst Digest Res, Kaunas, Lithuania, Ctr Mother & Child, Dept Paediat Gastroenterol, Kishinev, Moldova, Hosp Sao Joao, Dept Gastroenterol, Oporto, Portugal, Oporto Med Sch, Inst Pharmacol & Therapeut, Oporto, Portugal, Univ Porto, Inst Mol & Cell Biol, P-4100 Oporto, Portugal, Hosp Vale Sousa, Oporto, Portugal, Univ Med Victor Babes, Clin Gastroenterol, Timisoara, Romania, Moscow Reg Res Clin Inst, Dept Gastroenterol, Moscow, Russia, Complexo Hosp Univ Vigo, Dept Gastroenterol, Vigo, Spain, Linkoping Univ, Div Gastroenterol & Hepatol, Dept Clin & Expt Med, Linkoping, Sweden, Cty Council Ostergotland, Dept Gastroenterol UHL, Linkoping, Sweden, Orebro Univ Hosp, Div Gastroenterol, Dept Med, Orebro, Sweden, Rebro Univ, Sch Hlth & Med Sci, Orebro, Sweden, Univ London Imperial Coll Sci Technol & Med, St Marks Hosp, Sir Alan Parks Physiol Unit, London, England, Hull & E Yorkshire NHS Trust & Hull & York, Sch Med, Hull Royal Infirm, Kingston Upon Hull, N Humberside, England, Gentofte Univ Hosp, Dept Med Gastroenterol, Copenhagen, Denmarken
dc.identifier.journalGuten
dc.rights.accessOpen Accessen
refterms.dateFOA2018-09-12T13:36:54Z
html.description.abstractThe incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe. The reasons for these changes remain unknown. The aim of this study was to investigate whether an East-West gradient in the incidence of IBD in Europe exists.
html.description.abstractA prospective, uniformly diagnosed, population based inception cohort of IBD patients in 31 centres from 14 Western and eight Eastern European countries covering a total background population of approximately 10.1 million people was created. One-third of the centres had previous experience with inception cohorts. Patients were entered into a low cost, web based epidemiological database, making participation possible regardless of socioeconomic status and prior experience.
html.description.abstract1515 patients aged 15 years or older were included, of whom 535 (35%) were diagnosed with Crohn's disease (CD), 813 (54%) with ulcerative colitis (UC) and 167 (11%) with IBD unclassified (IBDU). The overall incidence rate ratios in all Western European centres were 1.9 (95% CI 1.5 to 2.4) for CD and 2.1 (95% CI 1.8 to 2.6) for UC compared with Eastern European centres. The median crude annual incidence rates per 100,000 in 2010 for CD were 6.5 (range 0-10.7) in Western European centres and 3.1 (range 0.4-11.5) in Eastern European centres, for UC 10.8 (range 2.9-31.5) and 4.1 (range 2.4-10.3), respectively, and for IBDU 1.9 (range 0-39.4) and 0 (range 0-1.2), respectively. In Western Europe, 92% of CD, 78% of UC and 74% of IBDU patients had a colonoscopy performed as the diagnostic procedure compared with 90%, 100% and 96%, respectively, in Eastern Europe. 8% of CD and 1% of UC patients in both regions underwent surgery within the first 3 months of the onset of disease. 7% of CD patients and 3% of UC patients from Western Europe received biological treatment as rescue therapy. Of all European CD patients, 20% received only 5-aminosalicylates as induction therapy.
html.description.abstractAn East-West gradient in IBD incidence exists in Europe. Among this inception cohort--including indolent and aggressive cases--international guidelines for diagnosis and initial treatment are not being followed uniformly by physicians.


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