Smoking as a risk factor for the radiological severity of rheumatoid arthritis: a study on six cohorts.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authorsde Rooy, D P C
van Nies, J A B
Kapetanovic, M C
Andersson, M L E
van der Heijde, D M F M
Gregersen, P K
Huizinga, T W J
van der Helm-van Mil, A H M
MetadataShow full item record
CitationAnn. Rheum. Dis. 2014, 73 (7):1384-7
AbstractSmoking is a risk factor for the development of anti -citrullinated protein antibodies (ACPA) positive rheumatoid arthritis (RA). Whether smoking predisposes to severe joint damage progression is not known, since deleterious, protective and neutral observations have been made.
To determine the effect of smoking on joint damage progression.
Smoking status was assessed in 3158 RA patients included in six cohorts (Leiden Early Arthritis Clinic (Leiden-EAC), BARFOT, Lund, Iceland, NDB and Wichita). In total 9412 radiographs were assessed. Multivariate normal regression and linear regression analyses were performed. Data were summarised in a random effects inverse variance meta-analysis.
When comparing radiological progression for RA patients that were never, past and current smokers, smoking was significantly associated with more severe joint damage in Leiden-EAC (p=0.042) and BARFOT (p=0.015) RA patients. No significant associations were found in the other cohorts, though a meta-analysis on the six cohorts showed significantly more severe joint damage progression in smokers (p=0.01). Since smoking predisposes to ACPA, analyses were repeated with ACPA as additional adjustment factor. Then the association was lost (meta-analysis p=0.29).
This multi-cohort study indicated that the effect of smoking on joint damage is mediated via ACPA and that smoking is not an independent risk factor for radiological progression in RA.
DescriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the page
RightsArchived with thanks to Annals of the rheumatic diseases
- SPP1 rs9138 variant contributes to the severity of radiological damage in anti-citrullinated protein autoantibody-negative rheumatoid arthritis.
- Authors: Juge PA, van Steenbergen HW, Constantin A, Tobon GJ, Schaeverbeke T, Gazal S, Combe B, Devauchelle-Pensec V, Nigon D, van der Helm-van Mil AH, Dieude P
- Issue date: 2014 Oct
- Association of valine and leucine at HLA-DRB1 position 11 with radiographic progression in rheumatoid arthritis, independent of the shared epitope alleles but not independent of anti-citrullinated protein antibodies.
- Authors: van Steenbergen HW, Raychaudhuri S, Rodríguez-Rodríguez L, Rantapää-Dahlqvist S, Berglin E, Toes RE, Huizinga TW, Fernández-Gutiérrez B, Gregersen PK, van der Helm-van Mil AH
- Issue date: 2015 Apr
- Rheumatoid Factor Is Associated With the Distribution of Hand Joint Destruction in Rheumatoid Arthritis.
- Authors: Terao C, Yamakawa N, Yano K, Markusse IM, Ikari K, Yoshida S, Furu M, Hashimoto M, Ito H, Fujii T, Ohmura K, Murakami K, Takahashi M, Hamaguchi M, Tabara Y, Taniguchi A, Momohara S, Raychaudhuri S, Allaart CF, Yamanaka H, Mimori T, Matsuda F
- Issue date: 2015 Dec
- Studies on ageing and the severity of radiographic joint damage in rheumatoid arthritis.
- Authors: Mangnus L, van Steenbergen HW, Lindqvist E, Brouwer E, Reijnierse M, Huizinga TW, Gregersen PK, Berglin E, Rantapää-Dahlqvist S, van der Heijde D, van der Helm-van Mil AH
- Issue date: 2015 Aug 24
- Genetic Factors for the Severity of ACPA-negative Rheumatoid Arthritis in 2 Cohorts of Early Disease: A Genome-wide Study.
- Authors: de Rooy DP, Tsonaka R, Andersson ML, Forslind K, Zhernakova A, Frank-Bertoncelj M, de Kovel CG, Koeleman BP, van der Heijde DM, Huizinga TW, Toes RE, Houwing-Duistermaat JJ, Ospelt C, Svensson B, van der Helm-van Mil AH
- Issue date: 2015 Aug