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dc.contributor.authorde Rooy, D P C
dc.contributor.authorvan Nies, J A B
dc.contributor.authorKapetanovic, M C
dc.contributor.authorKristjansdottir, H
dc.contributor.authorAndersson, M L E
dc.contributor.authorForslind, K
dc.contributor.authorvan der Heijde, D M F M
dc.contributor.authorGregersen, P K
dc.contributor.authorLindqvist, E
dc.contributor.authorHuizinga, T W J
dc.contributor.authorGröndal, G
dc.contributor.authorSvensson, B
dc.contributor.authorvan der Helm-van Mil, A H M
dc.date.accessioned2014-08-25T15:16:19Z
dc.date.available2014-08-25T15:16:19Z
dc.date.issued2014-07
dc.date.submitted2014
dc.identifier.citationAnn. Rheum. Dis. 2014, 73 (7):1384-7en
dc.identifier.issn1468-2060
dc.identifier.pmid24389296
dc.identifier.doi10.1136/annrheumdis-2013-203940
dc.identifier.urihttp://hdl.handle.net/2336/325173
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractSmoking is a risk factor for the development of anti -citrullinated protein antibodies (ACPA) positive rheumatoid arthritis (RA). Whether smoking predisposes to severe joint damage progression is not known, since deleterious, protective and neutral observations have been made.
dc.description.abstractTo determine the effect of smoking on joint damage progression.
dc.description.abstractSmoking status was assessed in 3158 RA patients included in six cohorts (Leiden Early Arthritis Clinic (Leiden-EAC), BARFOT, Lund, Iceland, NDB and Wichita). In total 9412 radiographs were assessed. Multivariate normal regression and linear regression analyses were performed. Data were summarised in a random effects inverse variance meta-analysis.
dc.description.abstractWhen comparing radiological progression for RA patients that were never, past and current smokers, smoking was significantly associated with more severe joint damage in Leiden-EAC (p=0.042) and BARFOT (p=0.015) RA patients. No significant associations were found in the other cohorts, though a meta-analysis on the six cohorts showed significantly more severe joint damage progression in smokers (p=0.01). Since smoking predisposes to ACPA, analyses were repeated with ACPA as additional adjustment factor. Then the association was lost (meta-analysis p=0.29).
dc.description.abstractThis multi-cohort study indicated that the effect of smoking on joint damage is mediated via ACPA and that smoking is not an independent risk factor for radiological progression in RA.
dc.description.sponsorshipBBMRI-Nl - Dutch government/NWO 184.021.007en
dc.language.isoenen
dc.publisherBMJ Publishing Groupen
dc.relation.urlhttp://dx.doi.org/10.1136/annrheumdis-2013-203940en
dc.rightsArchived with thanks to Annals of the rheumatic diseasesen
dc.subjectIktsýkien
dc.subjectÚlnliðiren
dc.subjectÖkklaliðiren
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshArthritis, Rheumatoid/epidemiology*en
dc.subject.meshAutoantibodies/immunologyen
dc.subject.meshCohort Studiesen
dc.subject.meshDisease Progressionen
dc.subject.meshFemaleen
dc.subject.meshFoot Joints/radiography*en
dc.subject.meshHand Joints/radiography*en
dc.subject.meshHumansen
dc.subject.meshLinear Modelsen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshMultivariate Analysisen
dc.subject.meshPeptides, Cyclic/immunologyen
dc.subject.meshSeverity of Illness Indexen
dc.subject.meshSmoking/epidemiology*en
dc.subject.meshArthritis, Rheumatoid/immunologyen
dc.subject.meshArthritis, Rheumatoid/radiographyen
dc.subject.meshSmoking/immunologyen
dc.titleSmoking as a risk factor for the radiological severity of rheumatoid arthritis: a study on six cohorts.en
dc.typeArticleen
dc.contributor.departmentLeiden Univ, Med Ctr, Dept Rheumatol, NL-2300 RC Leiden, Netherlands, Lund Univ, Dept Clin Sci, Rheumatol Sect, Lund, Sweden, Skane Univ Hosp, Dept Rheumatol, Lund, Sweden, Landspitali, Dept Rheumatol, Reykjavik, Iceland, Landspitali, Ctr Rheumatol Res, Reykjavik, Iceland, Spenshult Hosp, R&D Ctr, Oskarstrom, Sweden, Lund Univ, Dept Clin Sci, Sect Rheumatol, Sweden BARFOT Study Grp, Lund, Sweden, Helsingborgs Lasarett, Dept Med, Sect Rheumatol, Helsingborg, Sweden, Feinstein Inst Med Res, Manhasset, NY USA, North Shore Long Isl Jewish Hlth Syst, Manhasset, NY USAen
dc.identifier.journalAnnals of the rheumatic diseasesen
dc.rights.accessLandspítali Heilbrigðisvísindabókasafnis
html.description.abstractSmoking is a risk factor for the development of anti -citrullinated protein antibodies (ACPA) positive rheumatoid arthritis (RA). Whether smoking predisposes to severe joint damage progression is not known, since deleterious, protective and neutral observations have been made.
html.description.abstractTo determine the effect of smoking on joint damage progression.
html.description.abstractSmoking status was assessed in 3158 RA patients included in six cohorts (Leiden Early Arthritis Clinic (Leiden-EAC), BARFOT, Lund, Iceland, NDB and Wichita). In total 9412 radiographs were assessed. Multivariate normal regression and linear regression analyses were performed. Data were summarised in a random effects inverse variance meta-analysis.
html.description.abstractWhen comparing radiological progression for RA patients that were never, past and current smokers, smoking was significantly associated with more severe joint damage in Leiden-EAC (p=0.042) and BARFOT (p=0.015) RA patients. No significant associations were found in the other cohorts, though a meta-analysis on the six cohorts showed significantly more severe joint damage progression in smokers (p=0.01). Since smoking predisposes to ACPA, analyses were repeated with ACPA as additional adjustment factor. Then the association was lost (meta-analysis p=0.29).
html.description.abstractThis multi-cohort study indicated that the effect of smoking on joint damage is mediated via ACPA and that smoking is not an independent risk factor for radiological progression in RA.


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