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dc.contributor.authorEysteinsdóttir, Jenna Huld
dc.contributor.authorÓlafsson, Jón Hjaltalín
dc.contributor.authorAgnarsson, Bjarni A
dc.contributor.authorLúðvíksson, Björn Rúnar
dc.contributor.authorSigurgeirsson, Bárður
dc.date.accessioned2014-08-26T10:11:06Z
dc.date.available2014-08-26T10:11:06Z
dc.date.issued2014-02
dc.date.submitted2014
dc.identifier.citationPhotodermatol Photoimmunol Photomed 2014, 30 (1):25-34en
dc.identifier.issn1600-0781
dc.identifier.pmid24255991
dc.identifier.doi10.1111/phpp.12090
dc.identifier.urihttp://hdl.handle.net/2336/325194
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.en
dc.description.abstractThe combination of seawater baths and narrowband ultraviolet B (NB-UVB) is a known treatment for psoriasis. This study evaluates two treatment regimens that combine bathing in geothermal seawater and NB-UVB therapy in comparison with NB-UVB monotherapy.
dc.description.abstractSixty-eight psoriasis patients were randomly assigned to outpatient bathing in geothermal seawater combined with NB-UVB therapy three times a week, intensive daily treatment involving bathing in geothermal seawater combined with NB-UVB therapy, or NB-UVB therapy alone three times a week; treatment period was 6 weeks. Disease severity [Psoriasis Area Severity Index (PASI) and Lattice System Physician's Global Assessment scores], quality of life (Dermatology Life Quality Index) and histological changes were evaluated before, during and after treatment. The primary end point was the proportion of patients who achieved PASI 75 at 6 weeks.
dc.description.abstractAt 6 weeks, the percentage of patients who achieved PASI 75 and PASI 90 was significantly greater for both regimens, bathing in geothermal seawater three times a week (68.1% and 18.2%, respectively) and intensive treatment with geothermal seawater (73.1% and 42.3%, respectively) than for NB-UVB monotherapy (16.7% and 0%, respectively) (P < 0.05 in all comparisons). Clinical improvement was paralleled by improvement in quality of life and histological score and a reduction in NB-UVB doses.
dc.description.abstractBathing in geothermal seawater combined with NB-UVB therapy in psoriasis induces faster clinical and histological improvement, produces longer remission time and permits lower NB-UVB doses than UVB therapy alone.
dc.description.sponsorshipLandspitali University Hospital Research Fund Icelandic Technology Development Research Fund Blue Lagoon Ltd.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://dx.doi.org/10.1111/phpp.12090en
dc.rightsopenAccessen
dc.subjectSóríasisen
dc.subjectHeilsuböðen
dc.subjectsalten
dc.subjectGufuböðen
dc.subjectVatnsmeðferðen
dc.subject.meshAdulten
dc.subject.meshBalneology*en
dc.subject.meshCombined Modality Therapyen
dc.subject.meshFemaleen
dc.subject.meshHot Springs*en
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPhototherapy*en
dc.subject.meshPsoriasis/therapy*en
dc.subject.meshSeawater*en
dc.titlePsoriasis treatment: faster and long-standing results after bathing in geothermal seawater. A randomized trial of three UVB phototherapy regimens.en
dc.typeArticleen
dc.contributor.departmentUniv Iceland, Fac Med, Reykjavik, Iceland, Sahlgrens Univ Hosp, Dept Dermatol, S-41345 Gothenburg, Sweden, Landspitali Univ Hosp, Dept Dermatol, Reykjavik, Iceland, Landspitali Univ Hosp, Dept Immunol, Reykjavik, Iceland, Landspitali Univ Hosp, Dept Pathol, Reykjavik, Icelanden
dc.identifier.journalPhotodermatology, photoimmunology & photomedicineen
dc.rights.accessOpen Accessen
refterms.dateFOA2018-09-12T13:37:28Z
html.description.abstractThe combination of seawater baths and narrowband ultraviolet B (NB-UVB) is a known treatment for psoriasis. This study evaluates two treatment regimens that combine bathing in geothermal seawater and NB-UVB therapy in comparison with NB-UVB monotherapy.
html.description.abstractSixty-eight psoriasis patients were randomly assigned to outpatient bathing in geothermal seawater combined with NB-UVB therapy three times a week, intensive daily treatment involving bathing in geothermal seawater combined with NB-UVB therapy, or NB-UVB therapy alone three times a week; treatment period was 6 weeks. Disease severity [Psoriasis Area Severity Index (PASI) and Lattice System Physician's Global Assessment scores], quality of life (Dermatology Life Quality Index) and histological changes were evaluated before, during and after treatment. The primary end point was the proportion of patients who achieved PASI 75 at 6 weeks.
html.description.abstractAt 6 weeks, the percentage of patients who achieved PASI 75 and PASI 90 was significantly greater for both regimens, bathing in geothermal seawater three times a week (68.1% and 18.2%, respectively) and intensive treatment with geothermal seawater (73.1% and 42.3%, respectively) than for NB-UVB monotherapy (16.7% and 0%, respectively) (P < 0.05 in all comparisons). Clinical improvement was paralleled by improvement in quality of life and histological score and a reduction in NB-UVB doses.
html.description.abstractBathing in geothermal seawater combined with NB-UVB therapy in psoriasis induces faster clinical and histological improvement, produces longer remission time and permits lower NB-UVB doses than UVB therapy alone.


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