Maternal protein intake during pregnancy and offspring overweight 20 y later.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Bech, Bodil H
Henriksen, Tine B
Rasmussen, Morten A
Olsen, Sjurdur F
Halldorsson, Thorhallur I
MetadataShow full item record
CitationAm. J. Clin. Nutr. 2014: 1-10
AbstractAnimal studies have shown that protein intake in pregnancy may influence offspring fat metabolism and adiposity. The macronutrient ratio in human pregnancy appears to be important for offspring glucose tolerance; however, less is known about the influence on offspring adiposity.
We examined the relation between maternal dietary protein intake during pregnancy and offspring anthropometric measures and biomarkers of adiposity and glucose metabolism.
We used a prospective cohort of 965 Danish pregnant women recruited in 1988-1989 with offspring follow-up at 19-21 y. Macronutrient intake was collected in gestational week 30, and we divided protein according to its source (animal and vegetable including cereals). Offspring body mass index (BMI; in kg/m(2)) and waist circumference were recorded at follow-up (n = 695-697), and biomarkers were quantified in a subset (n = 443) of participants. We used multivariable linear and log-binomial regression to calculate effect estimates and 95% CIs for a 1:1-g substitution of carbohydrates for protein.
Offspring mean (±SD) BMI was 22.1 ± 3.3 and 22.8 ± 2.9 for women and men, respectively. The prevalence of overweight (BMI ≥25) was 16.9% for women and 19.1% for men. We showed that a 1:1-g substitution of animal protein for carbohydrates increased risk of BMI ≥25 in female [quartile 4 compared with quartile 1: risk ratio (RR): 3.36; 95% CI: 1.52, 7.42] and male (quartile 4 compared with quartile 1: RR: 2.22; 95% CI: 0.92, 5.35) offspring. These results appeared to be accounted for by protein from meat sources. The results could not be explained by postnatal risk factors.
Protein from animal sources, primarily meat products, consumed during pregnancy may increase risk of overweight in offspring; this association appeared to be stronger for female offspring. Because of the lack of information on postnatal exposure in this cohort, these results are hypothesis-generating and need to be replicating in other cohorts.
DescriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the page
RightsArchived with thanks to The American journal of clinical nutrition
- Maternal intake of fat in pregnancy and offspring metabolic health - A prospective study with 20 years of follow-up.
- Authors: Maslova E, Rytter D, Bech BH, Henriksen TB, Olsen SF, Halldorsson TI
- Issue date: 2016 Apr
- Maternal Macronutrient Intake during Pregnancy Is Associated with Neonatal Abdominal Adiposity: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) Study.
- Authors: Chen LW, Tint MT, Fortier MV, Aris IM, Bernard JY, Colega M, Gluckman PD, Saw SM, Chong YS, Yap F, Godfrey KM, Kramer MS, van Dam RM, Chong MF, Lee YS
- Issue date: 2016 Aug
- Prenatal exposure to perfluorooctanoate and risk of overweight at 20 years of age: a prospective cohort study.
- Authors: Halldorsson TI, Rytter D, Haug LS, Bech BH, Danielsen I, Becher G, Henriksen TB, Olsen SF
- Issue date: 2012 May
- Maternal protein intake in pregnancy and offspring metabolic health at age 9-16 y: results from a Danish cohort of gestational diabetes mellitus pregnancies and controls.
- Authors: Maslova E, Hansen S, Grunnet LG, Strøm M, Bjerregaard AA, Hjort L, Kampmann FB, Madsen CM, Baun Thuesen AC, Bech BH, Halldorsson TI, Vaag AA, Olsen SF
- Issue date: 2017 Aug
- Intake of carbohydrates during pregnancy in obese women is associated with fat mass in the newborn offspring.
- Authors: Renault KM, Carlsen EM, Nørgaard K, Nilas L, Pryds O, Secher NJ, Cortes D, Jensen JE, Olsen SF, Halldorsson TI
- Issue date: 2015 Dec