Risk of mortality in patients with psoriatic arthritis, rheumatoid arthritis and psoriasis: a longitudinal cohort study.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Ogdie, AlexisHaynes, Kevin
Troxel, Andrea B
Love, Thorvardur Jon
Hennessy, Sean
Choi, Hyon
Gelfand, Joel M
Issue Date
2014-01
Metadata
Show full item recordCitation
Ann. Rheum. Dis. 2014, 73 (1):149-53Abstract
There are conflicting reports in the literature of the mortality risk among patients with psoriatic arthritis (PsA). The objective of this study was to examine the risk of mortality in patients with PsA compared with matched controls, patients with psoriasis and those with rheumatoid arthritis (RA).A longitudinal cohort study was performed in a large UK medical record database, The Health Improvement Network, among patients with PsA, rheumatoid arthritis (RA) or psoriasis with data from 1994 to 2010. Unexposed controls were matched on practice and start date within the practice for each patient with PsA. Cox proportional hazards models were used to calculate the relative hazards for death.
Patients with PsA (N=8706), RA (N=41 752), psoriasis (N=138 424) and unexposed controls (N=82 258) were identified; 1 442 357 person-years were observed during which 21 825 deaths occurred. Compared with population controls, patients with PsA did not have an increased risk of mortality after adjusting for age and sex (disease-modifying antirheumatic drug (DMARD) users: HR 0.94, 95% CI 0.80 to 1.10; DMARD non-users: HR 1.06, 95% CI 0.94 to 1.19) whereas patients with RA had increased mortality (DMARD users: HR 1.59, 95% CI 1.52 to 1.66; DMARD non-users: HR 1.54, 95% CI 1.47 to 1.60). Patients with psoriasis who had not been prescribed a DMARD had a small increased risk of mortality (HR 1.08, 95% CI 1.04 to 1.12) while those who had been prescribed a DMARD, indicating severe psoriasis, were at increased risk (HR 1.75, 95% CI 1.56 to 1.95).
Patients with RA and psoriasis have increased mortality compared with the general population but patients with PsA do not have a significantly increased risk of mortality.
Additional Links
http://dx.doi.org/10.1136/annrheumdis-2012-202424http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883139/
http://ard.bmj.com/content/73/1/149.full.pdf+html
Rights
Archived with thanks to Annals of the rheumatic diseasesae974a485f413a2113503eed53cd6c53
10.1136/annrheumdis-2012-202424
Scopus Count
Collections
Related articles
- Risk of major cardiovascular events in patients with psoriatic arthritis, psoriasis and rheumatoid arthritis: a population-based cohort study.
- Authors: Ogdie A, Yu Y, Haynes K, Love TJ, Maliha S, Jiang Y, Troxel AB, Hennessy S, Kimmel SE, Margolis DJ, Choi H, Mehta NN, Gelfand JM
- Issue date: 2015 Feb
- Risk of venous thromboembolism in patients with psoriatic arthritis, psoriasis and rheumatoid arthritis: a general population-based cohort study.
- Authors: Ogdie A, Kay McGill N, Shin DB, Takeshita J, Jon Love T, Noe MH, Chiesa Fuxench ZC, Choi HK, Mehta NN, Gelfand JM
- Issue date: 2018 Oct 14
- Physical trauma recorded in primary care is associated with the onset of psoriatic arthritis among patients with psoriasis.
- Authors: Thorarensen SM, Lu N, Ogdie A, Gelfand JM, Choi HK, Love TJ
- Issue date: 2017 Mar
- Cause-specific mortality in patients with psoriatic arthritis and rheumatoid arthritis.
- Authors: Ogdie A, Maliha S, Shin D, Love TJ, Baker J, Jiang Y, Choi H, Gelfand JM
- Issue date: 2017 Jun 1
- Incidence and Management of Cardiovascular Risk Factors in Psoriatic Arthritis and Rheumatoid Arthritis: A Population-Based Study.
- Authors: Jafri K, Bartels CM, Shin D, Gelfand JM, Ogdie A
- Issue date: 2017 Jan