Retinal oxygen metabolism in healthy subjects and glaucoma patients.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsOlafsdottir, Olof Birna
Abegão Pinto, Luis
De Clerck, Eline
Gottfredsdottir, Maria Soffia
Kristjansdottir, Jona Valgerdur
Van Calster, Joachim
MetadataShow full item record
CitationBr J Ophthalmol. 2014, 98 (3):329-33
AbstractTo test whether retinal oxygen metabolism is different in glaucoma patients compared with healthy subjects.
This was a two-centre study where retinal vessel oxygen saturation was measured in glaucoma patients and healthy individuals with a non-invasive spectrophotometric retinal oximeter. Visual fields were obtained in the glaucoma patients.
No statistical difference was found in retinal oxygen saturation in arterioles (p=0.16), venules (p=0.16) and arteriovenous difference (p=0.24) when all glaucoma patients (n=74) were compared with healthy individuals (n=89). When patients with advanced glaucoma (visual field mean defect (MD ≥ 10 dB, n=21)) were compared with healthy individuals, the oxygen saturation in venules was higher in glaucoma patients (58.2% ± 5.4% vs 53.8% ± 6.4%; p=0.0054, mean ± SD) and the arteriovenous difference was lower in glaucoma patients (36.4% ± 4.7% vs 39.5% ± 5.7%; p=0.021). In glaucoma patients with mild glaucoma (visual field MD ≤ 5 dB, n=33), no statistical differences were found in retinal oxygen saturation compared with healthy individuals.
Glaucoma patients with advanced glaucoma have higher oxygen saturation in venules and lower arteriovenous difference in oxygen saturation compared with healthy individuals. The decreased arteriovenous difference in severe glaucoma may be related to lower oxygen consumption secondary to neuropathy.
RightsArchived with thanks to The British journal of ophthalmology
- Relationship between oxygen saturation of the retinal vessels and visual field defect in glaucoma patients: comparison with each hemifield.
- Authors: Shimazaki T, Hirooka K, Nakano Y, Nitta E, Ukegawa K, Sato S, Tsujikawa A
- Issue date: 2016 Dec
- Retinal oximetry in primary open-angle glaucoma.
- Authors: Olafsdottir OB, Hardarson SH, Gottfredsdottir MS, Harris A, Stefánsson E
- Issue date: 2011 Aug 16
- Oximetry in glaucoma: correlation of metabolic change with structural and functional damage.
- Authors: Vandewalle E, Abegão Pinto L, Olafsdottir OB, De Clerck E, Stalmans P, Van Calster J, Zeyen T, Stefánsson E, Stalmans I
- Issue date: 2014 Mar
- Oxygen venular saturation correlates with a functional loss in primary open-angle glaucoma and normal-tension glaucoma patients.
- Authors: Shimazaki T, Hirooka K, Nakano Y, Nitta E, Ukegawa K, Tsujikawa A
- Issue date: 2018 May
- Retinal Oxygen Saturation in Patients with Primary Open-angle Glaucoma Using a Non-flash Hypespectral Camera.
- Authors: Shahidi AM, Hudson C, Tayyari F, Flanagan JG
- Issue date: 2017 Apr