• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • ec_fundedresources to openaire
  • ec_fundedresources to openaire
  • View Item
  •   Home
  • ec_fundedresources to openaire
  • ec_fundedresources to openaire
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Mahajan, Anubha
Go, Min Jin
Zhang, Weihua
Below, Jennifer E
Gaulton, Kyle J
Ferreira, Teresa
Horikoshi, Momoko
Johnson, Andrew D
Ng, Maggie C Y
Prokopenko, Inga
Saleheen, Danish
Li, Xinzhong
Li, Yun
Liang, Junbin
Steinbach, Gerald
Liju, Samuel
Syvänen, Ann-Christine
Aung, Tin
Hayward, Caroline
Lim, Wei-Yen
Cruz, Miguel
Frayling, Timothy M
Metspalu, Andres
Chambers, Jonh C
Lind, Lars
Njølstad, Inger
Nöthen, Markus M
Ohnaka, Keizo
Hedman, Asa K
Takayanagi, Ryoichi
Ong, Twee Hee
Barnett, Anthony H
Froguel, Philippe
Lu, Wei
Owen, Katharine R
Palmer, Colin N A
Strawbridge, Rona J
Grrop, Leif C
Pankow, James S
Shu, Xiao Ou
Park, Kyong Soo
Parkin, Melissa
Takeuchi, Fumihiko
Frossard, Philippe
Pechlivanis, Sonali
Scott, Laura J
Pedersen, Nancy L
Peltonen, Leena
Herder, Christian
Perry, John R B
Peters, Annette
Groves, Chrisropher J
Barroso, Ines
Benediktsson, Rafn
Moebus, Susanne
Cai, Qiuyin
Cauchi, Stephane
Balkau, Beverley
Pinidiyapathirage, Janini M
Platou, Carl G
Potter, Simon
Price, Jackie F
Qi, Lu
Radha, Venkatesan
Rallidis, Loukianos
Gao, Yutang
Grundberg, Elin
Hofman, Albert
Rasheed, Asif
Melander, Olle
Tay, Wan Ting
Rathman, Wolfgang
McCarthy, Mark I
Stringham, Heather M
Rauramaa, Rainer
Basit, Abdul
Nakashima, Eitaro
Raychaudhuri, Soumya
Rayner, N William
Rees, Simon D
Mohan, Viswanathan
Hanis, Craig L
Rehnberg, Emil
Teslovich, Tanya M
Ripatti, Samuli
Robertson, Neil
Holmen, Oddgeir L
Gertow, Karl
Morris, Andrew P
Roden, Michael
Sun, Qi
Rossin, Elizabeth J
Rudan, Igor
Chang, Tien-Jyun
Rybin, Denis
Guiducci, Candace
Lindholm, Eero
Been, Latonya F
Zeggini, Eleftheria
Saaristo, Timo E
Salomaa, Veikko
Saltevo, Juha
Samuel, Maria
Campbell, Harry
Sanghera, Dharambir K
Chang, Yi-Cheng
Hovingh, Kees
Ma, Ronald C W
Saramies, Jouko
Gieger, Christian
Small, Kerrin S
Hamsten, Anders
Scott, James
Thorand, Barbara
Thorleifsson, Gudmar
Bergman, Richard N
Maeda, Shiro
Charpentier, Guillaume
Thorsteinsdottir, Unnur
Wang, Xu
Shah, Sonia
Tikkanen, Emmi
Trakalo, Joseph
Caulfield, Mark
Liu, Ching-Ti
Tremoli, Elena
Kooner, Jaspal
Trip, Mieke D
Tsai, Fuu Jen
Chen, Chien-Hsiun
Tuomi, Tiinamaija
Zimmet, Paul Z
Tuomilehto, Jaakko
Uitterlinden, Andre G
Mägi, Reedik
Valladares-Salgado, Adan
Boehm, Bernhard O
Liu, Jian Jun
Hui, Jennie
Hydrie, Zafar I
Isomaa, Bo
James, Alan
Hu, Cheng
Vedantam, Sailaja
Veglia, Fabrizio
Voight, Benjamin F
Wang, Congrong
Wareham, Nicholas J
Wennauer, Roman
Wickremasinghe, Ananda R
Lobbens, Stéphane
Männisto, Satu
Wilsgaard, Tom
Sivapalaratnam, Suthesh
Chen, Han
Wilson, James F
Hara, Kazuo
Chan, Juliana C N
Wiltshire, Steven
Humphries, Steve E
Boerwinkle, Eric
Winckler, Wendy
Wong, Tien Yin
Steinthorsdottir, Valgerdur
Gigante, Bruna
Wood, Andrew R
Chen, Yuan-Tsong
Wu, Jer-Yuarn
Wu, Ying
Matthews, David R
Hassanali, Neelam
Yamamoto, Ken
Chang, Li-Ching
Yamauchi, Toshimasa
Yang, Mingyu
Jowett, Jeremy B M
Yengo, Loic
Long, Jirong
Scott, Robert A
Hunt, Sarah E
Yokota, Mitsuhiro
Bonnycastle, Lori L
Young, Robin
Zabaneh, Delilah
Jackson, Anne U
Zhang, Fan
Kadowaki, Takashi
Meigs, James B
Shuldiner, Alan R
Zhang, Rong
Tai, E Shyong
Loos, Ruth J F
Zheng, Wei
Chia, Kee-Seng
Chidambaram, Manickam
Ikegami, Hiroshi
Sigurđsson, Gunnar
Kang, Hyun Min
Chines, Peter S
Hattersley, Andrew T
Cho, Nam H
Cho, Young Min
Jia, Weiping
Segrè, Ayellet V
Chuang, Lee-Ming
Grallert, Harald
Collins, Francis S
Cornelis, Marylin C
Abecasis, Goncalo R
Couper, David J
Crenshaw, Andrew T
van Dam, Rob M
Sijbrands, Eric
Danesh, John
Illig, Thomas
Beilby, John
Meyer, Julia
Mohlke, Karen L
Bao, Yuqian
Navarro, Pau
Das, Debashish
de Faire, Ulf
Dedoussis, George
Deloukas, Panos
Dimas, Antigone S
Dina, Christian
Doney, Alex S
Sehmi, Joban
Silveira, Angela
Donnelly, Peter J
Kanoni, Stavroula
Dorkhan, Mozhgan
Baldassarre, Damiano
Jöckel, Karl-Heinz
van Duijn, Cornelia
Mirza, Ghazala
Ingelsson, Erik
Dupuis, Josée
Edkins, Sarah
Carey, Jason
Elliott, Paul
Kao, Wen Hong L
Emilsson, Valur
Erbel, Raimund
Bell, Graeme I
Luan, Jian'an
Eriksson, Johan G
Jonsson, Anna
Escobedo, Jorge
Esko, Tonu
Eury, Elodie
Sennblad, Bengt
Altshuler, David
Mihailov, Evelin
Florez, Jose C
Islam, Muhammed
Fontanillas, Pierre
Forouhi, Nita G
Nakamura, Jiro
Forsen, Tom
Sim, Xueling
Lee, Jong-Young
Fox, Caroline
Han, Bok-Ghee
Shah, Nabi
Fraser, Ross M
Kathiresan, Sekar
Kato, Norihiro
Morris, Andrew D
Seielstad, Mark
Katulanda, Prasad
Lyssenko, Valeriya
Keinanen-Kiukaanniemi, Kirkka M
Kelly, Ann M
Ng, Peng-Keat
Bowden, Donald W
Khan, Hassan
Lindgren, Cecilia M
Khaw, Kay-Tee
Khor, Chiea-Chuen
Adair, Linda S
Kim, Hyung-Lae
Kim, Sangsoo
Teo, Yik Ying
Kim, Young Jin
Mühleisen, Thomas W
Hunter, David J
So, Wing Yee
Stirrups, Kathleen
Hu, Frank B
Kinnunen, Leena
Klopp, Norman
Kong, Augustine
Korpi-Hyövälti, Eeva
Kowlessur, Sudhir
Kraft, Peter
Kravic, Jasmina
Cho, Yoon Shin
Boehnke, Michael
Almgren, Peter
Kristensen, Malene M
Hreidarsson, Astradur B
Nica, Alexandra C
Krithika, S
Stančáková, Alena
Müller-Nurasyid, Martina
Kumar, Ashish
Kumate, Jesus
Jafar, Tazeen
Kuusisto, Johanna
Kwak, Soo Heon
Laakso, Markku
Hveem, Kristian
Shera, A Samad
Lagou, Vasiliki
Nilsson, Peter M
Lakka, Timo A
Langenberg, Claudia
Atalay, Mustafa
Cox, Nancy J
Stefansson, Kari
Langford, Cordelia
Musk, Bill
Lawrence, Robert
Leander, Karin
Suo, Chen
Lee, Jen-Mai
Parra, Esteban J
Grant, George B
Lee, Nanette R
Burtt, Noël
Li, Man
Show allShow less
Issue Date
2014-03

Metadata
Show full item record
Citation
Nat. Genet. 2014, 46 (3):234-44
Abstract
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.
Description
To access publisher's full text version of this article click on the hyperlink at the bottom of the page
Additional Links
http://dx.doi.org/10.1038/ng.2897
http://www.nature.com/ng/journal/v46/n3/pdf/ng.2897.pdf
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969612/
Rights
restrictedAccess
ae974a485f413a2113503eed53cd6c53
10.1038/ng.2897
Scopus Count
Collections
ec_fundedresources to openaire

entitlement

Related articles

  • Ancestry effects on type 2 diabetes genetic risk inference in Hispanic/Latino populations.
  • Authors: Chande AT, Rishishwar L, Conley AB, Valderrama-Aguirre A, Medina-Rivas MA, Jordan IK
  • Issue date: 2020 Jun 25
  • Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND).
  • Authors: Iyengar SK, Sedor JR, Freedman BI, Kao WH, Kretzler M, Keller BJ, Abboud HE, Adler SG, Best LG, Bowden DW, Burlock A, Chen YD, Cole SA, Comeau ME, Curtis JM, Divers J, Drechsler C, Duggirala R, Elston RC, Guo X, Huang H, Hoffmann MM, Howard BV, Ipp E, Kimmel PL, Klag MJ, Knowler WC, Kohn OF, Leak TS, Leehey DJ, Li M, Malhotra A, März W, Nair V, Nelson RG, Nicholas SB, O'Brien SJ, Pahl MV, Parekh RS, Pezzolesi MG, Rasooly RS, Rotimi CN, Rotter JI, Schelling JR, Seldin MF, Shah VO, Smiles AM, Smith MW, Taylor KD, Thameem F, Thornley-Brown DP, Truitt BJ, Wanner C, Weil EJ, Winkler CA, Zager PG, Igo RP Jr, Hanson RL, Langefeld CD, Family Investigation of Nephropathy and Diabetes (FIND).
  • Issue date: 2015 Aug
  • A comparison of type 2 diabetes risk allele load between African Americans and European Americans.
  • Authors: Keaton JM, Cooke Bailey JN, Palmer ND, Freedman BI, Langefeld CD, Ng MC, Bowden DW
  • Issue date: 2014 Dec
  • Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution.
  • Authors: Mägi R, Horikoshi M, Sofer T, Mahajan A, Kitajima H, Franceschini N, McCarthy MI, COGENT-Kidney Consortium, T2D-GENES Consortium., Morris AP
  • Issue date: 2017 Sep 15
  • Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.
  • Authors: Liu CT, Raghavan S, Maruthur N, Kabagambe EK, Hong J, Ng MC, Hivert MF, Lu Y, An P, Bentley AR, Drolet AM, Gaulton KJ, Guo X, Armstrong LL, Irvin MR, Li M, Lipovich L, Rybin DV, Taylor KD, Agyemang C, Palmer ND, Cade BE, Chen WM, Dauriz M, Delaney JA, Edwards TL, Evans DS, Evans MK, Lange LA, Leong A, Liu J, Liu Y, Nayak U, Patel SR, Porneala BC, Rasmussen-Torvik LJ, Snijder MB, Stallings SC, Tanaka T, Yanek LR, Zhao W, Becker DM, Bielak LF, Biggs ML, Bottinger EP, Bowden DW, Chen G, Correa A, Couper DJ, Crawford DC, Cushman M, Eicher JD, Fornage M, Franceschini N, Fu YP, Goodarzi MO, Gottesman O, Hara K, Harris TB, Jensen RA, Johnson AD, Jhun MA, Karter AJ, Keller MF, Kho AN, Kizer JR, Krauss RM, Langefeld CD, Li X, Liang J, Liu S, Lowe WL Jr, Mosley TH, North KE, Pacheco JA, Peyser PA, Patrick AL, Rice KM, Selvin E, Sims M, Smith JA, Tajuddin SM, Vaidya D, Wren MP, Yao J, Zhu X, Ziegler JT, Zmuda JM, Zonderman AB, Zwinderman AH, AAAG Consortium., CARe Consortium., COGENT-BP Consortium., eMERGE Consortium., MEDIA Consortium., Adeyemo A, Boerwinkle E, Ferrucci L, Hayes MG, Kardia SL, Miljkovic I, Pankow JS, Rotimi CN, Sale MM, Wagenknecht LE, Arnett DK, Chen YD, Nalls MA, MAGIC Consortium., Province MA, Kao WH, Siscovick DS, Psaty BM, Wilson JG, Loos RJ, Dupuis J, Rich SS, Florez JC, Rotter JI, Morris AP, Meigs JB
  • Issue date: 2016 Jul 7

DSpace software (copyright © 2002 - 2021)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.