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dc.contributor.authorMahajan, Anubhaen
dc.contributor.authorGo, Min Jinen
dc.contributor.authorZhang, Weihuaen
dc.contributor.authorBelow, Jennifer Een
dc.contributor.authorGaulton, Kyle Jen
dc.contributor.authorFerreira, Teresaen
dc.contributor.authorHorikoshi, Momokoen
dc.contributor.authorJohnson, Andrew Den
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dc.contributor.authorProkopenko, Ingaen
dc.contributor.authorSaleheen, Danishen
dc.contributor.authorLi, Xinzhongen
dc.contributor.authorLi, Yunen
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dc.contributor.authorLim, Wei-Yenen
dc.contributor.authorCruz, Miguelen
dc.contributor.authorFrayling, Timothy Men
dc.contributor.authorMetspalu, Andresen
dc.contributor.authorChambers, Jonh Cen
dc.contributor.authorLind, Larsen
dc.contributor.authorNjølstad, Ingeren
dc.contributor.authorNöthen, Markus Men
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dc.contributor.authorHedman, Asa Ken
dc.contributor.authorTakayanagi, Ryoichien
dc.contributor.authorOng, Twee Heeen
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dc.contributor.authorFroguel, Philippeen
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dc.contributor.authorOwen, Katharine Ren
dc.contributor.authorPalmer, Colin N Aen
dc.contributor.authorStrawbridge, Rona Jen
dc.contributor.authorGrrop, Leif Cen
dc.contributor.authorPankow, James Sen
dc.contributor.authorShu, Xiao Ouen
dc.contributor.authorPark, Kyong Sooen
dc.contributor.authorParkin, Melissaen
dc.contributor.authorTakeuchi, Fumihikoen
dc.contributor.authorFrossard, Philippeen
dc.contributor.authorPechlivanis, Sonalien
dc.contributor.authorScott, Laura Jen
dc.contributor.authorPedersen, Nancy Len
dc.contributor.authorPeltonen, Leenaen
dc.contributor.authorHerder, Christianen
dc.contributor.authorPerry, John R Ben
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dc.contributor.authorGroves, Chrisropher Jen
dc.contributor.authorBarroso, Inesen
dc.contributor.authorBenediktsson, Rafnen
dc.contributor.authorMoebus, Susanneen
dc.contributor.authorCai, Qiuyinen
dc.contributor.authorCauchi, Stephaneen
dc.contributor.authorBalkau, Beverleyen
dc.contributor.authorPinidiyapathirage, Janini Men
dc.contributor.authorPlatou, Carl Gen
dc.contributor.authorPotter, Simonen
dc.contributor.authorPrice, Jackie Fen
dc.contributor.authorQi, Luen
dc.contributor.authorRadha, Venkatesanen
dc.contributor.authorRallidis, Loukianosen
dc.contributor.authorGao, Yutangen
dc.contributor.authorGrundberg, Elinen
dc.contributor.authorHofman, Alberten
dc.contributor.authorRasheed, Asifen
dc.contributor.authorMelander, Olleen
dc.contributor.authorTay, Wan Tingen
dc.contributor.authorRathman, Wolfgangen
dc.contributor.authorMcCarthy, Mark Ien
dc.contributor.authorStringham, Heather Men
dc.contributor.authorRauramaa, Raineren
dc.contributor.authorBasit, Abdulen
dc.contributor.authorNakashima, Eitaroen
dc.contributor.authorRaychaudhuri, Soumyaen
dc.contributor.authorRayner, N Williamen
dc.contributor.authorRees, Simon Den
dc.contributor.authorMohan, Viswanathanen
dc.contributor.authorHanis, Craig Len
dc.contributor.authorRehnberg, Emilen
dc.contributor.authorTeslovich, Tanya Men
dc.contributor.authorRipatti, Samulien
dc.contributor.authorRobertson, Neilen
dc.contributor.authorHolmen, Oddgeir Len
dc.contributor.authorGertow, Karlen
dc.contributor.authorMorris, Andrew Pen
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dc.contributor.authorSun, Qien
dc.contributor.authorRossin, Elizabeth Jen
dc.contributor.authorRudan, Igoren
dc.contributor.authorChang, Tien-Jyunen
dc.contributor.authorRybin, Denisen
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dc.contributor.authorBeen, Latonya Fen
dc.contributor.authorZeggini, Eleftheriaen
dc.contributor.authorSaaristo, Timo Een
dc.contributor.authorSalomaa, Veikkoen
dc.contributor.authorSaltevo, Juhaen
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dc.contributor.authorCampbell, Harryen
dc.contributor.authorSanghera, Dharambir Ken
dc.contributor.authorChang, Yi-Chengen
dc.contributor.authorHovingh, Keesen
dc.contributor.authorMa, Ronald C Wen
dc.contributor.authorSaramies, Joukoen
dc.contributor.authorGieger, Christianen
dc.contributor.authorSmall, Kerrin Sen
dc.contributor.authorHamsten, Andersen
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dc.contributor.authorBergman, Richard Nen
dc.contributor.authorMaeda, Shiroen
dc.contributor.authorCharpentier, Guillaumeen
dc.contributor.authorThorsteinsdottir, Unnuren
dc.contributor.authorWang, Xuen
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dc.contributor.authorTikkanen, Emmien
dc.contributor.authorTrakalo, Josephen
dc.contributor.authorCaulfield, Marken
dc.contributor.authorLiu, Ching-Tien
dc.contributor.authorTremoli, Elenaen
dc.contributor.authorKooner, Jaspalen
dc.contributor.authorTrip, Mieke Den
dc.contributor.authorTsai, Fuu Jenen
dc.contributor.authorChen, Chien-Hsiunen
dc.contributor.authorTuomi, Tiinamaijaen
dc.contributor.authorZimmet, Paul Zen
dc.contributor.authorTuomilehto, Jaakkoen
dc.contributor.authorUitterlinden, Andre Gen
dc.contributor.authorMägi, Reediken
dc.contributor.authorValladares-Salgado, Adanen
dc.contributor.authorBoehm, Bernhard Oen
dc.contributor.authorLiu, Jian Junen
dc.contributor.authorHui, Jennieen
dc.contributor.authorHydrie, Zafar Ien
dc.contributor.authorIsomaa, Boen
dc.contributor.authorJames, Alanen
dc.contributor.authorHu, Chengen
dc.contributor.authorVedantam, Sailajaen
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dc.contributor.authorVoight, Benjamin Fen
dc.contributor.authorWang, Congrongen
dc.contributor.authorWareham, Nicholas Jen
dc.contributor.authorWennauer, Romanen
dc.contributor.authorWickremasinghe, Ananda Ren
dc.contributor.authorLobbens, Stéphaneen
dc.contributor.authorMännisto, Satuen
dc.contributor.authorWilsgaard, Tomen
dc.contributor.authorSivapalaratnam, Sutheshen
dc.contributor.authorChen, Hanen
dc.contributor.authorWilson, James Fen
dc.contributor.authorHara, Kazuoen
dc.contributor.authorChan, Juliana C Nen
dc.contributor.authorWiltshire, Stevenen
dc.contributor.authorHumphries, Steve Een
dc.contributor.authorBoerwinkle, Ericen
dc.contributor.authorWinckler, Wendyen
dc.contributor.authorWong, Tien Yinen
dc.contributor.authorSteinthorsdottir, Valgerduren
dc.contributor.authorGigante, Brunaen
dc.contributor.authorWood, Andrew Ren
dc.contributor.authorChen, Yuan-Tsongen
dc.contributor.authorWu, Jer-Yuarnen
dc.contributor.authorWu, Yingen
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dc.contributor.authorYamamoto, Kenen
dc.contributor.authorChang, Li-Chingen
dc.contributor.authorYamauchi, Toshimasaen
dc.contributor.authorYang, Mingyuen
dc.contributor.authorJowett, Jeremy B Men
dc.contributor.authorYengo, Loicen
dc.contributor.authorLong, Jirongen
dc.contributor.authorScott, Robert Aen
dc.contributor.authorHunt, Sarah Een
dc.contributor.authorYokota, Mitsuhiroen
dc.contributor.authorBonnycastle, Lori Len
dc.contributor.authorYoung, Robinen
dc.contributor.authorZabaneh, Delilahen
dc.contributor.authorJackson, Anne Uen
dc.contributor.authorZhang, Fanen
dc.contributor.authorKadowaki, Takashien
dc.contributor.authorMeigs, James Ben
dc.contributor.authorShuldiner, Alan Ren
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dc.contributor.authorTai, E Shyongen
dc.contributor.authorLoos, Ruth J Fen
dc.contributor.authorZheng, Weien
dc.contributor.authorChia, Kee-Sengen
dc.contributor.authorChidambaram, Manickamen
dc.contributor.authorIkegami, Hiroshien
dc.contributor.authorSigurđsson, Gunnaren
dc.contributor.authorKang, Hyun Minen
dc.contributor.authorChines, Peter Sen
dc.contributor.authorHattersley, Andrew Ten
dc.contributor.authorCho, Nam Hen
dc.contributor.authorCho, Young Minen
dc.contributor.authorJia, Weipingen
dc.contributor.authorSegrè, Ayellet Ven
dc.contributor.authorChuang, Lee-Mingen
dc.contributor.authorGrallert, Haralden
dc.contributor.authorCollins, Francis Sen
dc.contributor.authorCornelis, Marylin Cen
dc.contributor.authorAbecasis, Goncalo Ren
dc.contributor.authorCouper, David Jen
dc.contributor.authorCrenshaw, Andrew Ten
dc.contributor.authorvan Dam, Rob Men
dc.contributor.authorSijbrands, Ericen
dc.contributor.authorDanesh, Johnen
dc.contributor.authorIllig, Thomasen
dc.contributor.authorBeilby, Johnen
dc.contributor.authorMeyer, Juliaen
dc.contributor.authorMohlke, Karen Len
dc.contributor.authorBao, Yuqianen
dc.contributor.authorNavarro, Pauen
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dc.contributor.authorDeloukas, Panosen
dc.contributor.authorDimas, Antigone Sen
dc.contributor.authorDina, Christianen
dc.contributor.authorDoney, Alex Sen
dc.contributor.authorSehmi, Jobanen
dc.contributor.authorSilveira, Angelaen
dc.contributor.authorDonnelly, Peter Jen
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dc.contributor.authorDorkhan, Mozhganen
dc.contributor.authorBaldassarre, Damianoen
dc.contributor.authorJöckel, Karl-Heinzen
dc.contributor.authorvan Duijn, Corneliaen
dc.contributor.authorMirza, Ghazalaen
dc.contributor.authorIngelsson, Eriken
dc.contributor.authorDupuis, Joséeen
dc.contributor.authorEdkins, Sarahen
dc.contributor.authorCarey, Jasonen
dc.contributor.authorElliott, Paulen
dc.contributor.authorKao, Wen Hong Len
dc.contributor.authorEmilsson, Valuren
dc.contributor.authorErbel, Raimunden
dc.contributor.authorBell, Graeme Ien
dc.contributor.authorLuan, Jian'anen
dc.contributor.authorEriksson, Johan Gen
dc.contributor.authorJonsson, Annaen
dc.contributor.authorEscobedo, Jorgeen
dc.contributor.authorEsko, Tonuen
dc.contributor.authorEury, Elodieen
dc.contributor.authorSennblad, Bengten
dc.contributor.authorAltshuler, Daviden
dc.contributor.authorMihailov, Evelinen
dc.contributor.authorFlorez, Jose Cen
dc.contributor.authorIslam, Muhammeden
dc.contributor.authorFontanillas, Pierreen
dc.contributor.authorForouhi, Nita Gen
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dc.contributor.authorForsen, Tomen
dc.contributor.authorSim, Xuelingen
dc.contributor.authorLee, Jong-Youngen
dc.contributor.authorFox, Carolineen
dc.contributor.authorHan, Bok-Gheeen
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dc.contributor.authorFraser, Ross Men
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dc.contributor.authorKato, Norihiroen
dc.contributor.authorMorris, Andrew Den
dc.contributor.authorSeielstad, Marken
dc.contributor.authorKatulanda, Prasaden
dc.contributor.authorLyssenko, Valeriyaen
dc.contributor.authorKeinanen-Kiukaanniemi, Kirkka Men
dc.contributor.authorKelly, Ann Men
dc.contributor.authorNg, Peng-Keaten
dc.contributor.authorBowden, Donald Wen
dc.contributor.authorKhan, Hassanen
dc.contributor.authorLindgren, Cecilia Men
dc.contributor.authorKhaw, Kay-Teeen
dc.contributor.authorKhor, Chiea-Chuenen
dc.contributor.authorAdair, Linda Sen
dc.contributor.authorKim, Hyung-Laeen
dc.contributor.authorKim, Sangsooen
dc.contributor.authorTeo, Yik Yingen
dc.contributor.authorKim, Young Jinen
dc.contributor.authorMühleisen, Thomas Wen
dc.contributor.authorHunter, David Jen
dc.contributor.authorSo, Wing Yeeen
dc.contributor.authorStirrups, Kathleenen
dc.contributor.authorHu, Frank Ben
dc.contributor.authorKinnunen, Leenaen
dc.contributor.authorKlopp, Normanen
dc.contributor.authorKong, Augustineen
dc.contributor.authorKorpi-Hyövälti, Eevaen
dc.contributor.authorKowlessur, Sudhiren
dc.contributor.authorKraft, Peteren
dc.contributor.authorKravic, Jasminaen
dc.contributor.authorCho, Yoon Shinen
dc.contributor.authorBoehnke, Michaelen
dc.contributor.authorAlmgren, Peteren
dc.contributor.authorKristensen, Malene Men
dc.contributor.authorHreidarsson, Astradur Ben
dc.contributor.authorNica, Alexandra Cen
dc.contributor.authorKrithika, Sen
dc.contributor.authorStančáková, Alenaen
dc.contributor.authorMüller-Nurasyid, Martinaen
dc.contributor.authorKumar, Ashishen
dc.contributor.authorKumate, Jesusen
dc.contributor.authorJafar, Tazeenen
dc.contributor.authorKuusisto, Johannaen
dc.contributor.authorKwak, Soo Heonen
dc.contributor.authorLaakso, Markkuen
dc.contributor.authorHveem, Kristianen
dc.contributor.authorShera, A Samaden
dc.contributor.authorLagou, Vasilikien
dc.contributor.authorNilsson, Peter Men
dc.contributor.authorLakka, Timo Aen
dc.contributor.authorLangenberg, Claudiaen
dc.contributor.authorAtalay, Mustafaen
dc.contributor.authorCox, Nancy Jen
dc.contributor.authorStefansson, Karien
dc.contributor.authorLangford, Cordeliaen
dc.contributor.authorMusk, Billen
dc.contributor.authorLawrence, Roberten
dc.contributor.authorLeander, Karinen
dc.contributor.authorSuo, Chenen
dc.contributor.authorLee, Jen-Maien
dc.contributor.authorParra, Esteban Jen
dc.contributor.authorGrant, George Ben
dc.contributor.authorLee, Nanette Ren
dc.contributor.authorBurtt, Noëlen
dc.contributor.authorLi, Manen
dc.date.accessioned2014-09-01T11:44:28Z
dc.date.available2014-09-01T11:44:28Z
dc.date.issued2014-03
dc.date.submitted2014
dc.identifier.citationNat. Genet. 2014, 46 (3):234-44en
dc.identifier.issn1546-1718
dc.identifier.pmid24509480
dc.identifier.doi10.1038/ng.2897
dc.identifier.urihttp://hdl.handle.net/2336/325606
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractTo further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.
dc.description.sponsorshipCanadian Institutes of Health Research Medical Research Council UK G0601261 Mexico Convocatoria SSA/IMMS/ISSSTE-CONACYT 2012-2 clave 150352 IMSS R-2011-785-018 CONACYT Salud-2007-C01-71068 US National Institutes of Health DK062370 HG000376 DK085584 DK085545 DK073541 DK085501 Wellcome Trust WT098017 WT090532 WT090367 WT098381 WT081682 WT085475en
dc.description.sponsorshipinfo:eu-repo/grantAgreement/EC/FP7/201413en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/201413en
dc.relation.urlhttp://dx.doi.org/10.1038/ng.2897en
dc.relation.urlhttp://www.nature.com/ng/journal/v46/n3/pdf/ng.2897.pdfen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969612/en
dc.rightsrestrictedAccessen
dc.subjectSykursýkien
dc.subjectArfgengien
dc.subject.meshAllelesen
dc.subject.meshAsian Continental Ancestry Groupen
dc.subject.meshCase-Control Studiesen
dc.subject.meshDiabetes Mellitus, Type 2en
dc.subject.meshEuropean Continental Ancestry Groupen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshGenome-Wide Association Studyen
dc.subject.meshHispanic Americansen
dc.subject.meshHumansen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshRisk Factorsen
dc.titleGenome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.en
dc.typeArticleen
dc.contributor.department[ 1 ] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England [ 2 ] Natl Inst Hlth, Ctr Genome Sci, Gangoe Myeon, Yeonje Ri, South Korea [ 3 ] Univ London Imperial Coll Sci Technol & Med, London, England [ 4 ] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA [ 5 ] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX1 2JD, England [ 6 ] NHLBI, Framingham Heart Study, Framingham, MA USA [ 7 ] Wake Forest Sch Med, Ctr Genom & Personalized Med Res, Winston Salem, NC USA [ 8 ] Wake Forest Sch Med, Ctr Diabet Res, Winston Salem, NC USA [ 9 ] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, London, England [ 10 ] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England [ 11 ] Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan [ 12 ] Natl Univ Singapore, Dept Epidemiol & Publ Hlth, Singapore 117548, Singapore [ 13 ] Wellcome Trust Sanger Inst, Cambridge, England [ 14 ] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA [ 15 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dc.identifier.journalNature geneticsen
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractTo further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.


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