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dc.contributor.authorMahajan, Anubha
dc.contributor.authorGo, Min Jin
dc.contributor.authorZhang, Weihua
dc.contributor.authorBelow, Jennifer E
dc.contributor.authorGaulton, Kyle J
dc.contributor.authorFerreira, Teresa
dc.contributor.authorHorikoshi, Momoko
dc.contributor.authorJohnson, Andrew D
dc.contributor.authorNg, Maggie C Y
dc.contributor.authorProkopenko, Inga
dc.contributor.authorSaleheen, Danish
dc.contributor.authorLi, Xinzhong
dc.contributor.authorLi, Yun
dc.contributor.authorLiang, Junbin
dc.contributor.authorSteinbach, Gerald
dc.contributor.authorLiju, Samuel
dc.contributor.authorSyvänen, Ann-Christine
dc.contributor.authorAung, Tin
dc.contributor.authorHayward, Caroline
dc.contributor.authorLim, Wei-Yen
dc.contributor.authorCruz, Miguel
dc.contributor.authorFrayling, Timothy M
dc.contributor.authorMetspalu, Andres
dc.contributor.authorChambers, Jonh C
dc.contributor.authorLind, Lars
dc.contributor.authorNjølstad, Inger
dc.contributor.authorNöthen, Markus M
dc.contributor.authorOhnaka, Keizo
dc.contributor.authorHedman, Asa K
dc.contributor.authorTakayanagi, Ryoichi
dc.contributor.authorOng, Twee Hee
dc.contributor.authorBarnett, Anthony H
dc.contributor.authorFroguel, Philippe
dc.contributor.authorLu, Wei
dc.contributor.authorOwen, Katharine R
dc.contributor.authorPalmer, Colin N A
dc.contributor.authorStrawbridge, Rona J
dc.contributor.authorGrrop, Leif C
dc.contributor.authorPankow, James S
dc.contributor.authorShu, Xiao Ou
dc.contributor.authorPark, Kyong Soo
dc.contributor.authorParkin, Melissa
dc.contributor.authorTakeuchi, Fumihiko
dc.contributor.authorFrossard, Philippe
dc.contributor.authorPechlivanis, Sonali
dc.contributor.authorScott, Laura J
dc.contributor.authorPedersen, Nancy L
dc.contributor.authorPeltonen, Leena
dc.contributor.authorHerder, Christian
dc.contributor.authorPerry, John R B
dc.contributor.authorPeters, Annette
dc.contributor.authorGroves, Chrisropher J
dc.contributor.authorBarroso, Ines
dc.contributor.authorBenediktsson, Rafn
dc.contributor.authorMoebus, Susanne
dc.contributor.authorCai, Qiuyin
dc.contributor.authorCauchi, Stephane
dc.contributor.authorBalkau, Beverley
dc.contributor.authorPinidiyapathirage, Janini M
dc.contributor.authorPlatou, Carl G
dc.contributor.authorPotter, Simon
dc.contributor.authorPrice, Jackie F
dc.contributor.authorQi, Lu
dc.contributor.authorRadha, Venkatesan
dc.contributor.authorRallidis, Loukianos
dc.contributor.authorGao, Yutang
dc.contributor.authorGrundberg, Elin
dc.contributor.authorHofman, Albert
dc.contributor.authorRasheed, Asif
dc.contributor.authorMelander, Olle
dc.contributor.authorTay, Wan Ting
dc.contributor.authorRathman, Wolfgang
dc.contributor.authorMcCarthy, Mark I
dc.contributor.authorStringham, Heather M
dc.contributor.authorRauramaa, Rainer
dc.contributor.authorBasit, Abdul
dc.contributor.authorNakashima, Eitaro
dc.contributor.authorRaychaudhuri, Soumya
dc.contributor.authorRayner, N William
dc.contributor.authorRees, Simon D
dc.contributor.authorMohan, Viswanathan
dc.contributor.authorHanis, Craig L
dc.contributor.authorRehnberg, Emil
dc.contributor.authorTeslovich, Tanya M
dc.contributor.authorRipatti, Samuli
dc.contributor.authorRobertson, Neil
dc.contributor.authorHolmen, Oddgeir L
dc.contributor.authorGertow, Karl
dc.contributor.authorMorris, Andrew P
dc.contributor.authorRoden, Michael
dc.contributor.authorSun, Qi
dc.contributor.authorRossin, Elizabeth J
dc.contributor.authorRudan, Igor
dc.contributor.authorChang, Tien-Jyun
dc.contributor.authorRybin, Denis
dc.contributor.authorGuiducci, Candace
dc.contributor.authorLindholm, Eero
dc.contributor.authorBeen, Latonya F
dc.contributor.authorZeggini, Eleftheria
dc.contributor.authorSaaristo, Timo E
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorSaltevo, Juha
dc.contributor.authorSamuel, Maria
dc.contributor.authorCampbell, Harry
dc.contributor.authorSanghera, Dharambir K
dc.contributor.authorChang, Yi-Cheng
dc.contributor.authorHovingh, Kees
dc.contributor.authorMa, Ronald C W
dc.contributor.authorSaramies, Jouko
dc.contributor.authorGieger, Christian
dc.contributor.authorSmall, Kerrin S
dc.contributor.authorHamsten, Anders
dc.contributor.authorScott, James
dc.contributor.authorThorand, Barbara
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorBergman, Richard N
dc.contributor.authorMaeda, Shiro
dc.contributor.authorCharpentier, Guillaume
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorWang, Xu
dc.contributor.authorShah, Sonia
dc.contributor.authorTikkanen, Emmi
dc.contributor.authorTrakalo, Joseph
dc.contributor.authorCaulfield, Mark
dc.contributor.authorLiu, Ching-Ti
dc.contributor.authorTremoli, Elena
dc.contributor.authorKooner, Jaspal
dc.contributor.authorTrip, Mieke D
dc.contributor.authorTsai, Fuu Jen
dc.contributor.authorChen, Chien-Hsiun
dc.contributor.authorTuomi, Tiinamaija
dc.contributor.authorZimmet, Paul Z
dc.contributor.authorTuomilehto, Jaakko
dc.contributor.authorUitterlinden, Andre G
dc.contributor.authorMägi, Reedik
dc.contributor.authorValladares-Salgado, Adan
dc.contributor.authorBoehm, Bernhard O
dc.contributor.authorLiu, Jian Jun
dc.contributor.authorHui, Jennie
dc.contributor.authorHydrie, Zafar I
dc.contributor.authorIsomaa, Bo
dc.contributor.authorJames, Alan
dc.contributor.authorHu, Cheng
dc.contributor.authorVedantam, Sailaja
dc.contributor.authorVeglia, Fabrizio
dc.contributor.authorVoight, Benjamin F
dc.contributor.authorWang, Congrong
dc.contributor.authorWareham, Nicholas J
dc.contributor.authorWennauer, Roman
dc.contributor.authorWickremasinghe, Ananda R
dc.contributor.authorLobbens, Stéphane
dc.contributor.authorMännisto, Satu
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorSivapalaratnam, Suthesh
dc.contributor.authorChen, Han
dc.contributor.authorWilson, James F
dc.contributor.authorHara, Kazuo
dc.contributor.authorChan, Juliana C N
dc.contributor.authorWiltshire, Steven
dc.contributor.authorHumphries, Steve E
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorWinckler, Wendy
dc.contributor.authorWong, Tien Yin
dc.contributor.authorSteinthorsdottir, Valgerdur
dc.contributor.authorGigante, Bruna
dc.contributor.authorWood, Andrew R
dc.contributor.authorChen, Yuan-Tsong
dc.contributor.authorWu, Jer-Yuarn
dc.contributor.authorWu, Ying
dc.contributor.authorMatthews, David R
dc.contributor.authorHassanali, Neelam
dc.contributor.authorYamamoto, Ken
dc.contributor.authorChang, Li-Ching
dc.contributor.authorYamauchi, Toshimasa
dc.contributor.authorYang, Mingyu
dc.contributor.authorJowett, Jeremy B M
dc.contributor.authorYengo, Loic
dc.contributor.authorLong, Jirong
dc.contributor.authorScott, Robert A
dc.contributor.authorHunt, Sarah E
dc.contributor.authorYokota, Mitsuhiro
dc.contributor.authorBonnycastle, Lori L
dc.contributor.authorYoung, Robin
dc.contributor.authorZabaneh, Delilah
dc.contributor.authorJackson, Anne U
dc.contributor.authorZhang, Fan
dc.contributor.authorKadowaki, Takashi
dc.contributor.authorMeigs, James B
dc.contributor.authorShuldiner, Alan R
dc.contributor.authorZhang, Rong
dc.contributor.authorTai, E Shyong
dc.contributor.authorLoos, Ruth J F
dc.contributor.authorZheng, Wei
dc.contributor.authorChia, Kee-Seng
dc.contributor.authorChidambaram, Manickam
dc.contributor.authorIkegami, Hiroshi
dc.contributor.authorSigurđsson, Gunnar
dc.contributor.authorKang, Hyun Min
dc.contributor.authorChines, Peter S
dc.contributor.authorHattersley, Andrew T
dc.contributor.authorCho, Nam H
dc.contributor.authorCho, Young Min
dc.contributor.authorJia, Weiping
dc.contributor.authorSegrè, Ayellet V
dc.contributor.authorChuang, Lee-Ming
dc.contributor.authorGrallert, Harald
dc.contributor.authorCollins, Francis S
dc.contributor.authorCornelis, Marylin C
dc.contributor.authorAbecasis, Goncalo R
dc.contributor.authorCouper, David J
dc.contributor.authorCrenshaw, Andrew T
dc.contributor.authorvan Dam, Rob M
dc.contributor.authorSijbrands, Eric
dc.contributor.authorDanesh, John
dc.contributor.authorIllig, Thomas
dc.contributor.authorBeilby, John
dc.contributor.authorMeyer, Julia
dc.contributor.authorMohlke, Karen L
dc.contributor.authorBao, Yuqian
dc.contributor.authorNavarro, Pau
dc.contributor.authorDas, Debashish
dc.contributor.authorde Faire, Ulf
dc.contributor.authorDedoussis, George
dc.contributor.authorDeloukas, Panos
dc.contributor.authorDimas, Antigone S
dc.contributor.authorDina, Christian
dc.contributor.authorDoney, Alex S
dc.contributor.authorSehmi, Joban
dc.contributor.authorSilveira, Angela
dc.contributor.authorDonnelly, Peter J
dc.contributor.authorKanoni, Stavroula
dc.contributor.authorDorkhan, Mozhgan
dc.contributor.authorBaldassarre, Damiano
dc.contributor.authorJöckel, Karl-Heinz
dc.contributor.authorvan Duijn, Cornelia
dc.contributor.authorMirza, Ghazala
dc.contributor.authorIngelsson, Erik
dc.contributor.authorDupuis, Josée
dc.contributor.authorEdkins, Sarah
dc.contributor.authorCarey, Jason
dc.contributor.authorElliott, Paul
dc.contributor.authorKao, Wen Hong L
dc.contributor.authorEmilsson, Valur
dc.contributor.authorErbel, Raimund
dc.contributor.authorBell, Graeme I
dc.contributor.authorLuan, Jian'an
dc.contributor.authorEriksson, Johan G
dc.contributor.authorJonsson, Anna
dc.contributor.authorEscobedo, Jorge
dc.contributor.authorEsko, Tonu
dc.contributor.authorEury, Elodie
dc.contributor.authorSennblad, Bengt
dc.contributor.authorAltshuler, David
dc.contributor.authorMihailov, Evelin
dc.contributor.authorFlorez, Jose C
dc.contributor.authorIslam, Muhammed
dc.contributor.authorFontanillas, Pierre
dc.contributor.authorForouhi, Nita G
dc.contributor.authorNakamura, Jiro
dc.contributor.authorForsen, Tom
dc.contributor.authorSim, Xueling
dc.contributor.authorLee, Jong-Young
dc.contributor.authorFox, Caroline
dc.contributor.authorHan, Bok-Ghee
dc.contributor.authorShah, Nabi
dc.contributor.authorFraser, Ross M
dc.contributor.authorKathiresan, Sekar
dc.contributor.authorKato, Norihiro
dc.contributor.authorMorris, Andrew D
dc.contributor.authorSeielstad, Mark
dc.contributor.authorKatulanda, Prasad
dc.contributor.authorLyssenko, Valeriya
dc.contributor.authorKeinanen-Kiukaanniemi, Kirkka M
dc.contributor.authorKelly, Ann M
dc.contributor.authorNg, Peng-Keat
dc.contributor.authorBowden, Donald W
dc.contributor.authorKhan, Hassan
dc.contributor.authorLindgren, Cecilia M
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorKhor, Chiea-Chuen
dc.contributor.authorAdair, Linda S
dc.contributor.authorKim, Hyung-Lae
dc.contributor.authorKim, Sangsoo
dc.contributor.authorTeo, Yik Ying
dc.contributor.authorKim, Young Jin
dc.contributor.authorMühleisen, Thomas W
dc.contributor.authorHunter, David J
dc.contributor.authorSo, Wing Yee
dc.contributor.authorStirrups, Kathleen
dc.contributor.authorHu, Frank B
dc.contributor.authorKinnunen, Leena
dc.contributor.authorKlopp, Norman
dc.contributor.authorKong, Augustine
dc.contributor.authorKorpi-Hyövälti, Eeva
dc.contributor.authorKowlessur, Sudhir
dc.contributor.authorKraft, Peter
dc.contributor.authorKravic, Jasmina
dc.contributor.authorCho, Yoon Shin
dc.contributor.authorBoehnke, Michael
dc.contributor.authorAlmgren, Peter
dc.contributor.authorKristensen, Malene M
dc.contributor.authorHreidarsson, Astradur B
dc.contributor.authorNica, Alexandra C
dc.contributor.authorKrithika, S
dc.contributor.authorStančáková, Alena
dc.contributor.authorMüller-Nurasyid, Martina
dc.contributor.authorKumar, Ashish
dc.contributor.authorKumate, Jesus
dc.contributor.authorJafar, Tazeen
dc.contributor.authorKuusisto, Johanna
dc.contributor.authorKwak, Soo Heon
dc.contributor.authorLaakso, Markku
dc.contributor.authorHveem, Kristian
dc.contributor.authorShera, A Samad
dc.contributor.authorLagou, Vasiliki
dc.contributor.authorNilsson, Peter M
dc.contributor.authorLakka, Timo A
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorAtalay, Mustafa
dc.contributor.authorCox, Nancy J
dc.contributor.authorStefansson, Kari
dc.contributor.authorLangford, Cordelia
dc.contributor.authorMusk, Bill
dc.contributor.authorLawrence, Robert
dc.contributor.authorLeander, Karin
dc.contributor.authorSuo, Chen
dc.contributor.authorLee, Jen-Mai
dc.contributor.authorParra, Esteban J
dc.contributor.authorGrant, George B
dc.contributor.authorLee, Nanette R
dc.contributor.authorBurtt, Noël
dc.contributor.authorLi, Man
dc.date.accessioned2014-09-01T11:44:28Z
dc.date.available2014-09-01T11:44:28Z
dc.date.issued2014-03
dc.date.submitted2014
dc.identifier.citationNat. Genet. 2014, 46 (3):234-44en
dc.identifier.issn1546-1718
dc.identifier.pmid24509480
dc.identifier.doi10.1038/ng.2897
dc.identifier.urihttp://hdl.handle.net/2336/325606
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractTo further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.
dc.description.sponsorshipCanadian Institutes of Health Research Medical Research Council UK G0601261 Mexico Convocatoria SSA/IMMS/ISSSTE-CONACYT 2012-2 clave 150352 IMSS R-2011-785-018 CONACYT Salud-2007-C01-71068 US National Institutes of Health DK062370 HG000376 DK085584 DK085545 DK073541 DK085501 Wellcome Trust WT098017 WT090532 WT090367 WT098381 WT081682 WT085475en
dc.description.sponsorshipinfo:eu-repo/grantAgreement/EC/FP7/201413en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/201413en
dc.relation.urlhttp://dx.doi.org/10.1038/ng.2897en
dc.relation.urlhttp://www.nature.com/ng/journal/v46/n3/pdf/ng.2897.pdfen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969612/en
dc.rightsrestrictedAccessen
dc.subjectSykursýkien
dc.subjectArfgengien
dc.subject.meshAllelesen
dc.subject.meshAsian Continental Ancestry Groupen
dc.subject.meshCase-Control Studiesen
dc.subject.meshDiabetes Mellitus, Type 2en
dc.subject.meshEuropean Continental Ancestry Groupen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshGenome-Wide Association Studyen
dc.subject.meshHispanic Americansen
dc.subject.meshHumansen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshRisk Factorsen
dc.titleGenome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.en
dc.typeArticleen
dc.contributor.department[ 1 ] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England [ 2 ] Natl Inst Hlth, Ctr Genome Sci, Gangoe Myeon, Yeonje Ri, South Korea [ 3 ] Univ London Imperial Coll Sci Technol & Med, London, England [ 4 ] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA [ 5 ] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX1 2JD, England [ 6 ] NHLBI, Framingham Heart Study, Framingham, MA USA [ 7 ] Wake Forest Sch Med, Ctr Genom & Personalized Med Res, Winston Salem, NC USA [ 8 ] Wake Forest Sch Med, Ctr Diabet Res, Winston Salem, NC USA [ 9 ] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, London, England [ 10 ] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England [ 11 ] Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan [ 12 ] Natl Univ Singapore, Dept Epidemiol & Publ Hlth, Singapore 117548, Singapore [ 13 ] Wellcome Trust Sanger Inst, Cambridge, England [ 14 ] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA [ 15 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CB2 2QQ, England [ 28 ] Addenbrookes Hosp, Inst Metab Sci, Cambridge Biomed Res Ctr, Natl Inst Hlth Res, Cambridge, England [ 29 ] Baqai Inst Diabetol & Endocrinol, Karachi, Pakistan [ 30 ] Univ Oklahoma, Hlth Sci Ctr, Coll Med, Dept Pediat,Sect Genet, Oklahoma City, OK 73190 USA [ 31 ] Sir Charles Gairdner Hosp, Busselton Populat Med Res Inst, Nedlands, WA 6009, Australia [ 32 ] Queen Elizabeth II Med Ctr, PathWest Lab Med Western Australia, Nedlands, WA, Australia [ 33 ] Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia [ 34 ] Univ Chicago, Dept Med, Chicago, IL 60637 USA [ 35 ] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA [ 36 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 37 ] Landspitali Univ Hosp, Reykjavik, Iceland [ 38 ] Cedars Sinai Med Ctr, Diabet & Obes Res Inst, Los Angeles, CA 90048 USA [ 39 ] Univ Med Ctr Ulm, Div Endocrinol & Diabet, Dept Internal Med, Ulm, Germany [ 40 ] Nanyang Technol Univ, Lee Kong Chian LKC Sch Med, Singapore 639798, 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dc.identifier.journalNature geneticsen
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractTo further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.


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