Fracture risk assessment in older adults using a combination of selected quantitative computed tomography bone measures: a subanalysis of the Age, Gene/Environment Susceptibility-Reykjavik Study.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsRianon, Nahid J
Lang, Thomas F
Jonsson, Brynjolfur Y
Kapadia, Asha S
Taylor, Wendell C
Selwyn, Beatrice J
Launer, Lenore J
Harris, Tamara B
MetadataShow full item record
CitationJ Clin Densitom. 2014; 17 (1):25-31
AbstractBone mineral density (BMD) and geometric bone measures are individually associated with prevalent osteoporotic fractures. Whether an aggregate of these measures would better associate with fractures has not been examined. We examined relationships between self-reported fractures and selected bone measures acquired by quantitative computerized tomography (QCT), a composite bone score, and QCT-acquired dual-energy X-ray absorptiometry-like total femur BMD in 2110 men and 2682 women in the Age, Gene/Environment Susceptibility-Reykjavik Study. The combined bone score was generated by summing gender-specific Z-scores for 4 QCT measures: vertebral trabecular BMD, femur neck cortical thickness, femur neck trabecular BMD, and femur neck minimal cross-sectional area. Except for the latter measure, lower scores for QCT measures, singly and combined, showed positive (p < 0.05) associations with fractures. Results remained the same in stratified models for participants not taking bone-promoting medication. In women on bone-promoting medication, greater femur neck cortical thickness and trabecular BMD were significantly associated with fracture status. However, the association between fracture and combined bone score was not stronger than the associations between fracture and individual measures or total femur BMD. Thus, the selected measures did not all similarly associate with fracture status and did not appear to have an additive effect on fracture status.
DescriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the page
RightsArchived with thanks to Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
- QCT of the proximal femur--which parameters should be measured to discriminate hip fracture?
- Authors: Museyko O, Bousson V, Adams J, Laredo J-, Engelke K
- Issue date: 2016 Mar
- Distribution of bone density and cortical thickness in the proximal femur and their association with hip fracture in postmenopausal women: a quantitative computed tomography study.
- Authors: Yang L, Udall WJ, McCloskey EV, Eastell R
- Issue date: 2014 Jan
- Association of 3D Geometric Measures Derived From Quantitative Computed Tomography With Hip Fracture Risk in Older Men.
- Authors: Borggrefe J, de Buhr T, Shrestha S, Marshall LM, Orwoll E, Peters K, Black DM, Glüer CC, Osteoporotic Fractures in Men (MrOS) Study Research Group.
- Issue date: 2016 Aug
- In vivo discrimination of hip fracture with quantitative computed tomography: results from the prospective European Femur Fracture Study (EFFECT).
- Authors: Bousson VD, Adams J, Engelke K, Aout M, Cohen-Solal M, Bergot C, Haguenauer D, Goldberg D, Champion K, Aksouh R, Vicaut E, Laredo JD
- Issue date: 2011 Apr
- Assessment of the strength of proximal femur in vitro: relationship to femoral bone mineral density and femoral geometry.
- Authors: Cheng XG, Lowet G, Boonen S, Nicholson PH, Brys P, Nijs J, Dequeker J
- Issue date: 1997 Mar