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Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa.

dc.contributor.authorEysteinsson, Thor
dc.contributor.authorHardarson, Sveinn H
dc.contributor.authorBragason, David
dc.contributor.authorStefánsson, Einar
dc.date.accessioned2014-09-08T15:56:47Zen
dc.date.available2014-09-08T15:56:47Zen
dc.date.issued2014-08en
dc.date.submitted2014en
dc.identifier.citationActa Ophthalmol. 2014, 92 (5):449-53en
dc.identifier.issn1755-3768en
dc.identifier.pmid24767302en
dc.identifier.doi10.1111/aos.12359en
dc.identifier.urihttp://hdl.handle.net/2336/325945en
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractTo assess retinal vessel oxygen saturation and retinal vessel diameter in retinitis pigmentosa.
dc.description.abstractA retinal oximeter (Oxymap ehf., Reykjavik, Iceland) was used to measure retinal vessel oxygen saturation and vessel diameter in ten patients with retinitis pigmentosa (RP) (mean age 49 years, range 23-71 years). Results were compared with age- and gender-matched healthy individuals. All patients had advanced stage of the disease with visual fields restricted to the macular region.
dc.description.abstractOxygen saturation in retinal venules was 58.0 ± 6.2% in patients with RP and 53.4 ± 4.8% in healthy subjects (p = 0.017). Oxygen saturation in retinal arterioles was not significantly different between groups (p = 0.65). The mean diameter of retinal arterioles was 8.9 ± 1.6 pixels in patients with RP and 11.4 ± 1.2 in healthy controls (p < 0.0001). The corresponding diameters for venules were 10.1 ± 1.2 (RP) and 15.3 ± 1.7 (healthy, p < 0.0001).
dc.description.abstractIncreased venous saturation and decreased retinal vessel diameter suggest decreased oxygen delivery from the retinal circulation in retinitis pigmentosa. This is probably secondary to tissue atrophy and reduced oxygen consumption.
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://dx.doi.org/10.1111/aos.12359en
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1111/aos.12359/pdfen
dc.rightsArchived with thanks to Acta ophthalmologicaen
dc.subjectSjónhimnaen
dc.subjectSykursýkien
dc.subjectSjónskerðingen
dc.subject.meshRetinal Vesselsen
dc.subject.meshOxygen/blooden
dc.subject.meshRetinitis Pigmentosaen
dc.subject.meshDiabetic Retinopathyen
dc.subject.meshPigmentationen
dc.subject.meshEpitheliumen
dc.subject.meshOximetryen
dc.subject.meshAdulten
dc.subject.meshBlood Pressure/physiologyen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIntraocular Pressure/physiologyen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshRetina/pathologyen
dc.subject.meshRetinal Artery/physiopathology*en
dc.subject.meshRetinal Vein/physiopathology*en
dc.subject.meshRetinitis Pigmentosa/physiopathology*en
dc.subject.meshTomography, Optical Coherenceen
dc.subject.meshYoung Adulten
dc.titleRetinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa.en
dc.typeArticleen
dc.contributor.departmentUniv Iceland, Reykjavik, Iceland, Univ Iceland, Landspitali Univ Hosp, Reykjavik, Icelanden
dc.identifier.journalActa ophthalmologicaen
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractTo assess retinal vessel oxygen saturation and retinal vessel diameter in retinitis pigmentosa.
html.description.abstractA retinal oximeter (Oxymap ehf., Reykjavik, Iceland) was used to measure retinal vessel oxygen saturation and vessel diameter in ten patients with retinitis pigmentosa (RP) (mean age 49 years, range 23-71 years). Results were compared with age- and gender-matched healthy individuals. All patients had advanced stage of the disease with visual fields restricted to the macular region.
html.description.abstractOxygen saturation in retinal venules was 58.0 ± 6.2% in patients with RP and 53.4 ± 4.8% in healthy subjects (p = 0.017). Oxygen saturation in retinal arterioles was not significantly different between groups (p = 0.65). The mean diameter of retinal arterioles was 8.9 ± 1.6 pixels in patients with RP and 11.4 ± 1.2 in healthy controls (p < 0.0001). The corresponding diameters for venules were 10.1 ± 1.2 (RP) and 15.3 ± 1.7 (healthy, p < 0.0001).
html.description.abstractIncreased venous saturation and decreased retinal vessel diameter suggest decreased oxygen delivery from the retinal circulation in retinitis pigmentosa. This is probably secondary to tissue atrophy and reduced oxygen consumption.


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