Biological insights from 108 schizophrenia-associated genetic loci.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Issue Date
2014-07-24
Metadata
Show full item recordCitation
Nature 2014, 511 (7510):421-7Abstract
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.Description
To access publisher's full text version of this article click on the hyperlink at the bottom of the pageAdditional Links
http://dx.doi.org/10.1038/nature13595http://www.nature.com/nature/journal/v511/n7510/pdf/nature13595.pdf
Rights
Archived with thanks to Natureae974a485f413a2113503eed53cd6c53
10.1038/nature13595
Scopus Count
Collections
Related articles
- Genetics: finding genes for schizophrenia.
- Authors: Flint J, Munafò MR
- Issue date: 2014 Aug 18
- Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia.
- Authors: Devor A, Andreassen OA, Wang Y, Mäki-Marttunen T, Smeland OB, Fan CC, Schork AJ, Holland D, Thompson WK, Witoelar A, Chen CH, Desikan RS, McEvoy LK, Djurovic S, Greengard P, Svenningsson P, Einevoll GT, Dale AM
- Issue date: 2017 Jun
- Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence.
- Authors: Smeland OB, Bahrami S, Frei O, Shadrin A, O'Connell K, Savage J, Watanabe K, Krull F, Bettella F, Steen NE, Ueland T, Posthuma D, Djurovic S, Dale AM, Andreassen OA
- Issue date: 2020 Apr
- Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools.
- Authors: Bahrami S, Hindley G, Winsvold BS, O'Connell KS, Frei O, Shadrin A, Cheng W, Bettella F, Rødevand L, Odegaard KJ, Fan CC, Pirinen MJ, Hautakangas HM, HUNT All-In Headache ., Dale AM, Djurovic S, Smeland OB, Andreassen OA
- Issue date: 2022 Mar 29
- Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.
- Authors: Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S, Cameron D, Hamshere ML, Han J, Hubbard L, Lynham A, Mantripragada K, Rees E, MacCabe JH, McCarroll SA, Baune BT, Breen G, Byrne EM, Dannlowski U, Eley TC, Hayward C, Martin NG, McIntosh AM, Plomin R, Porteous DJ, Wray NR, Caballero A, Geschwind DH, Huckins LM, Ruderfer DM, Santiago E, Sklar P, Stahl EA, Won H, Agerbo E, Als TD, Andreassen OA, Bækvad-Hansen M, Mortensen PB, Pedersen CB, Børglum AD, Bybjerg-Grauholm J, Djurovic S, Durmishi N, Pedersen MG, Golimbet V, Grove J, Hougaard DM, Mattheisen M, Molden E, Mors O, Nordentoft M, Pejovic-Milovancevic M, Sigurdsson E, Silagadze T, Hansen CS, Stefansson K, Stefansson H, Steinberg S, Tosato S, Werge T, GERAD1 Consortium., CRESTAR Consortium., Collier DA, Rujescu D, Kirov G, Owen MJ, O'Donovan MC, Walters JTR
- Issue date: 2018 Mar