Show simple item record

dc.contributor.authorHelgadóttir, Hólmfridur
dc.contributor.authorMetz, David C
dc.contributor.authorYang, Yu-Xiao
dc.contributor.authorRhim, Andrew D
dc.contributor.authorBjörnsson, Einar S
dc.date.accessioned2014-09-12T14:54:56Z
dc.date.available2014-09-12T14:54:56Z
dc.date.issued2014-02
dc.date.submitted2014
dc.identifier.citationDig Liver Dis. 2014, 46 (2):125-30en
dc.identifier.issn1878-3562
dc.identifier.pmid24210828
dc.identifier.doi10.1016/j.dld.2013.09.021
dc.identifier.urihttp://hdl.handle.net/2336/326077
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractDyspepsia develops in healthy volunteers after withdrawal of proton-pump inhibitors. This phenomenon, attributed to rebound acid hypersecretion, is thought to be mediated by reflex hypergastrinemia.
dc.description.abstractTo measure fasting and postprandial gastrin in patients on long-term proton-pump inhibitor treatment and correlate gastrin levels with the duration of treatment and other potential predictors.
dc.description.abstractIn this cross sectional study patients, with erosive esophagitis, on long-term proton-pump inhibitor treatment and healthy controls underwent gastrin measurements at baseline and four times following a meal and Helicobacter pylori status was determined.
dc.description.abstractA total of 100 patients and 50 controls were studied. Pre- and postprandial gastrin levels were higher in patients (p<0.001). No significant correlation was found between the area under the gastrin-curve and the treatment duration. Female patients had significantly higher gastrin levels than males pre- and postprandial, whereas such differences was not found in the control group. Female gender was the only independent predictor of s-gastrin levels (OR 2.50 compared to males, 95% CI: 1.08-5.76, p=0.032) in the patient group.
dc.description.abstractGastrin values were higher in patients compared to controls. There was no correlation between gastrin levels and treatment duration. Female patients had significantly higher gastrin values than males.
dc.description.sponsorshipNational Institutes of Health/DK088945 DK19525 Penn Radioimmunoassay and Biomarkers Core of the Diabetes Research Center/DK050306 Penn Center for Molecular Studies in Digestive and Liver Diseases Molecular Pathology and Imaging Core (ADR) Research Fund of the National University Hospital of Iceland University of Iceland Research Funden
dc.language.isoenen
dc.publisherElsevier Science Ltd.en
dc.relation.urlhttp://dx.doi.org/10.1016/j.dld.2013.09.021en
dc.rightsArchived with thanks to Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liveren
dc.subjectMeltingarfærasjúkdómaren
dc.subjectLyfjagjöfen
dc.subject.meshDyspepsia/etiologyen
dc.subject.meshProton Pump Inhibitors/adverse effects*en
dc.subject.meshEsophagitis, Peptic/complicationsen
dc.subject.meshGastrins/blood*en
dc.subject.meshAgeden
dc.subject.meshCase-Control Studiesen
dc.subject.meshChromogranin Aen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshDyspepsia/blooden
dc.subject.meshEsophagitis, Peptic/drug therapy*en
dc.subject.meshFemaleen
dc.subject.meshHelicobacter Infections/complicationsen
dc.subject.meshHelicobacter pylorien
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPostprandial Period*en
dc.subject.meshSex Factorsen
dc.subject.meshSubstance Withdrawal Syndrome/etiology*en
dc.titleThe effects of long-term therapy with proton pump inhibitors on meal stimulated gastrin.en
dc.typeArticleen
dc.contributor.departmentUniv Iceland, Fac Med, Reykjavik, Iceland, Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA, Natl Univ Hosp Iceland, Dept Internal Med, Div Gastroenterol & Hepatol, Reykjavik, Icelanden
dc.identifier.journalDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liveren
dc.rights.accessNational Consortium - Landsaðganguren
html.description.abstractDyspepsia develops in healthy volunteers after withdrawal of proton-pump inhibitors. This phenomenon, attributed to rebound acid hypersecretion, is thought to be mediated by reflex hypergastrinemia.
html.description.abstractTo measure fasting and postprandial gastrin in patients on long-term proton-pump inhibitor treatment and correlate gastrin levels with the duration of treatment and other potential predictors.
html.description.abstractIn this cross sectional study patients, with erosive esophagitis, on long-term proton-pump inhibitor treatment and healthy controls underwent gastrin measurements at baseline and four times following a meal and Helicobacter pylori status was determined.
html.description.abstractA total of 100 patients and 50 controls were studied. Pre- and postprandial gastrin levels were higher in patients (p<0.001). No significant correlation was found between the area under the gastrin-curve and the treatment duration. Female patients had significantly higher gastrin levels than males pre- and postprandial, whereas such differences was not found in the control group. Female gender was the only independent predictor of s-gastrin levels (OR 2.50 compared to males, 95% CI: 1.08-5.76, p=0.032) in the patient group.
html.description.abstractGastrin values were higher in patients compared to controls. There was no correlation between gastrin levels and treatment duration. Female patients had significantly higher gastrin values than males.


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record