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dc.contributor.authorJörgensen, G H
dc.contributor.authorGardulf, A
dc.contributor.authorSigurdsson, M I
dc.contributor.authorArnlaugsson, S
dc.contributor.authorHammarström, L
dc.contributor.authorLudviksson, B R
dc.date.accessioned2014-09-15T14:14:04Z
dc.date.available2014-09-15T14:14:04Z
dc.date.issued2014-03
dc.date.submitted2014
dc.identifier.citationQual Life Res. 2014, 23 (2):645-58en
dc.identifier.issn1573-2649
dc.identifier.pmid24022790
dc.identifier.doi10.1007/s11136-013-0491-9
dc.identifier.urihttp://hdl.handle.net/2336/326154
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractSelective IgA deficiency (SIgAD) is the most common primary immunodeficiency with a prevalence of 1/600 in the general population. Any targeted health-related quality of life (HRQL) study of adults with SIgAD has never been presented. The objectives of the study were to compare HRQL between SIgAD adults and randomly selected age- and gender-matched population controls, and to identify risk factors for poor HRQL.
dc.description.abstractThirty-two SIgAD individuals and 63 controls answered three questionnaires (clinical data, Short Form-36 Health Survey (SF-36), infection-related HRQL) at baseline before undergoing medical/dental examinations and laboratory assessments. HRQL in SIgAD was re-evaluated after 6 and 12 months.
dc.description.abstractBaseline: Selective IgA deficiency individuals reported significantly increased fear of contracting infections (p < 0.01). Those scoring high on fear also perceived significantly poorer physical health (p < 0.01). SF-36 results indicated that SIgAD individuals perceived poorer HRQL, although this was not statistically significant. Follow-up: Compared with SF-36 responses at baseline, SIgAD individuals reported significantly more pain (p < 0.01) at 6 months, poorer general health (p < 0.05) and summarised physical HRQL (p < 0.01) at 6 and 12 months and decreased vitality at 12 months. The summarised mental scale remained stable over time. Risk factors for poor HRQL: The number of antibiotic treatments during the previous year (p < 0.001), number of daily medications (p < 0.01), allergic rhinoconjunctivitis (p < 0.05), chronic musculoskeletal symptoms at least every week (p < 0.05) and anxiety and/or insomnia (p < 0.05) were identified as independent risk factors for poor HRQL.
dc.description.abstractThe study highlights the importance of identifying and thoroughly evaluating, educating and following up individuals with SIgAD, as their HRQL may be negatively affected due to health problems possible to prevent and treat.
dc.description.sponsorshipLandspitali University Hospital Research Fund, Icelandic Research Fund, Karolinska Institutet (KI Fonder), Stockholm, Sweden, Division of Research and Development, Primary Care, County Council of Uppsala, Sweden.en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttp://dx.doi.org/10.1007/s11136-013-0491-9en
dc.relation.urlhttp://download.springer.com/static/pdf/253/art%253A10.1007%252Fs11136-013-0491-9.pdf?auth66=1410963379_8480e53564dda7a16b1214c6d38241b9&ext=.pdfen
dc.rightsArchived with thanks to Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitationen
dc.subjectOfnæmien
dc.subjectSjúklingafræðslaen
dc.subjectÁhættuþættiren
dc.subject.meshHealth Status*en
dc.subject.meshQuality of Life*en
dc.subject.meshIgA Deficiency/physiopathology*en
dc.subject.meshIcelanden
dc.subject.meshImmunologic Deficiency Syndromesen
dc.subject.meshPatient Education as Topicen
dc.subject.meshRisk Factorsen
dc.subject.meshPatient Outcome Assessmenten
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshCase-Control Studiesen
dc.subject.meshFemaleen
dc.subject.meshHealth Surveysen
dc.subject.meshHumansen
dc.subject.meshIgA Deficiency/psychology*en
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshQuestionnairesen
dc.titleHealth-related quality of life (HRQL) in immunodeficient adults with selective IgA deficiency compared with age- and gender-matched controls and identification of risk factors for poor HRQL.en
dc.typeArticleen
dc.contributor.departmentUniv Iceland, Dept Med, Reykjavik, Iceland, Landspitali Univ Hosp, Dept Immunol, IS-101 Reykjavik, Iceland, Karolinska Univ Hosp, Karolinska Inst, Dept Lab Med, Div Clin Immunol, Stockholm, Sweden, Univ Iceland, Fac Odontol, IS-101 Reykjavik, Icelanden
dc.identifier.journalQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitationen
dc.rights.accessNational Consortium - Landsaðganguren
html.description.abstractSelective IgA deficiency (SIgAD) is the most common primary immunodeficiency with a prevalence of 1/600 in the general population. Any targeted health-related quality of life (HRQL) study of adults with SIgAD has never been presented. The objectives of the study were to compare HRQL between SIgAD adults and randomly selected age- and gender-matched population controls, and to identify risk factors for poor HRQL.
html.description.abstractThirty-two SIgAD individuals and 63 controls answered three questionnaires (clinical data, Short Form-36 Health Survey (SF-36), infection-related HRQL) at baseline before undergoing medical/dental examinations and laboratory assessments. HRQL in SIgAD was re-evaluated after 6 and 12 months.
html.description.abstractBaseline: Selective IgA deficiency individuals reported significantly increased fear of contracting infections (p < 0.01). Those scoring high on fear also perceived significantly poorer physical health (p < 0.01). SF-36 results indicated that SIgAD individuals perceived poorer HRQL, although this was not statistically significant. Follow-up: Compared with SF-36 responses at baseline, SIgAD individuals reported significantly more pain (p < 0.01) at 6 months, poorer general health (p < 0.05) and summarised physical HRQL (p < 0.01) at 6 and 12 months and decreased vitality at 12 months. The summarised mental scale remained stable over time. Risk factors for poor HRQL: The number of antibiotic treatments during the previous year (p < 0.001), number of daily medications (p < 0.01), allergic rhinoconjunctivitis (p < 0.05), chronic musculoskeletal symptoms at least every week (p < 0.05) and anxiety and/or insomnia (p < 0.05) were identified as independent risk factors for poor HRQL.
html.description.abstractThe study highlights the importance of identifying and thoroughly evaluating, educating and following up individuals with SIgAD, as their HRQL may be negatively affected due to health problems possible to prevent and treat.


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