Renal, gastrointestinal, and hepatic late effects in survivors of childhood acute myeloid leukemia treated with chemotherapy only--a NOPHO-AML study.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Skou, Anne-SofieGlosli, Heidi
Jahnukainen, Kirsi
Jarfelt, Marianne
Jónmundsson, Guðmundur K
Malmros-Svennilson, Johan
Nysom, Karsten
Hasle, Henrik
Issue Date
2014-09
Metadata
Show full item recordCitation
Pediatr Blood Cancer 2014, 61(9):1638-43Abstract
We investigated the spectrum, frequency, and risk factors for renal, gastrointestinal, and hepatic late adverse effects in survivors of childhood acute myeloid leukemia (AML) without relapse treated with chemotherapy alone according to three consecutive AML trials by the Nordic Society of Pediatric Hematology and Oncology (NOPHO).A population-based cohort of children treated for AML according to the NOPHO-AML-84, -88, and -93 trials included 138 eligible survivors of whom 102 (74%) completed a questionnaire and 104 (75%) had a clinical examination and blood sampling performed. Eighty-five of 94 (90%) eligible sibling controls completed a similar questionnaire. Siblings had no clinical examination or blood sampling performed.
At a median of 11 years (range 4-25) after diagnosis, renal, gastrointestinal, and hepatic disorders were rare both in survivors of childhood AML and in sibling controls, with no significant differences. Ferritin was elevated in 21 (21%) AML survivors but none had biochemical signs of liver damage. Viral hepatitis was present in three and cholelithiasis in two AML survivors. One adult survivor had hypertension, two had slightly elevated systolic blood pressure, and eight survivors had slightly elevated diastolic blood pressure. These persons all had normal creatinine and cystatin C levels. Marginal abnormalities in potassium, magnesium, calcium, or bicarbonate levels were found in 34 survivors.
Survivors of childhood AML treated with chemotherapy only experienced few renal, gastrointestinal, and hepatic late effects.
Description
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.Additional Links
http://onlinelibrary.wiley.com/doi/10.1002/pbc.25069/pdfhttp://dx.doi.org/10.1002/pbc.25069
Rights
Archived with thanks to Pediatric blood & cancerae974a485f413a2113503eed53cd6c53
10.1002/pbc.25069
Scopus Count
Collections
Related articles
- Quality of health in survivors of childhood acute myeloid leukemia treated with chemotherapy only: a NOPHO-AML study.
- Authors: Molgaard-Hansen L, Glosli H, Jahnukainen K, Jarfelt M, Jónmundsson GK, Malmros-Svennilson J, Nysom K, Hasle H, Nordic Society of Pediatric Hematology and Oncology.
- Issue date: 2011 Dec 15
- Pubertal development and fertility in survivors of childhood acute myeloid leukemia treated with chemotherapy only: a NOPHO-AML study.
- Authors: Molgaard-Hansen L, Skou AS, Juul A, Glosli H, Jahnukainen K, Jarfelt M, Jónmundsson GK, Malmros J, Nysom K, Hasle H, Nordic Society of Pediatric Hematology and Oncology.
- Issue date: 2013 Dec
- Hearing Status in Survivors of Childhood Acute Myeloid Leukemia Treated With Chemotherapy Only: A NOPHO-AML Study.
- Authors: Skou AS, Olsen SØ, Nielsen LH, Glosli H, Jahnukainen K, Jarfelt M, Jónmundsson GK, Malmros J, Nysom K, Hasle H, Nordic Society of Pediatric Hematology and Oncology (NOPHO).
- Issue date: 2019 Jan
- Surveillance of hepatic late adverse effects in a large cohort of long-term survivors of childhood cancer: prevalence and risk factors.
- Authors: Mulder RL, Kremer LC, Koot BG, Benninga MA, Knijnenburg SL, van der Pal HJ, Koning CC, Oldenburger F, Wilde JC, Taminiau JA, Caron HN, van Dalen EC
- Issue date: 2013 Jan
- Cardiac function in survivors of childhood acute myeloid leukemia treated with chemotherapy only: a NOPHO-AML study.
- Authors: Jarfelt M, Andersen NH, Glosli H, Jahnukainen K, Jónmundsson GK, Malmros J, Nysom K, Hasle H, Nordic Society of Pediatric Hematology and Oncology (NOPHO).
- Issue date: 2016 Jul