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Anti-C1q antibodies in systemic lupus erythematosus.

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Authors
Orbai, A-M
Truedsson, L
Sturfelt, G
Nived, O
Fang, H
Alarcón, Gs
Gordon, C
Merrill, Jt
Fortin, Pr
Bruce, In
Isenberg, DA
Wallace, Dj
Ramsey-Goldman, R
Bae, S-C
Hanly, Jg
Sanchez-Guerrero, J
Clarke, Ae
Aranow, Cb
Manzi, S
Urowitz, Mb
Gladman, Dd
Kalunian, Kc
Costner, Mi
Werth, Vp
Zoma, A
Bernatsky, S
Ruiz-Irastorza, G
Khamashta, Ma
Jacobsen, S
Buyon, Jp
Maddison, P
Dooley, Ma
Van Vollenhoven, Rf
Ginzler, E
Stoll, T
Peschken, C
Jorizzo, Jl
Callen, Jp
Lim, Ss
Fessler, Bj
Inanc, M
Kamen, Dl
Rahman, A
Steinsson, K
Franks, Ag
Sigler, L
Hameed, S
Pham, N
Brey, R
Weisman, Mh
McGwin, G
Magder, Ls
Petri, M
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Issue Date
2014-08-14

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Citation
Lupus 2015 Jan;24(1):42-9
Abstract
Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study.
Information and blood samples were obtained in a cross-sectional study from patients with SLE (n = 308) and other rheumatologic diseases (n = 389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA.
Prevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR = 2.7, 95% CI: 1.8-4, p < 0.001). Anti-C1q was associated with proteinuria (OR = 3.0, 95% CI: 1.7-5.1, p < 0.001), red cell casts (OR = 2.6, 95% CI: 1.2-5.4, p = 0.015), anti-dsDNA (OR = 3.4, 95% CI: 1.9-6.1, p < 0.001) and anti-Smith (OR = 2.8, 95% CI: 1.5-5.0, p = 0.01). Anti-C1q was independently associated with renal involvement after adjustment for demographics, ANA, anti-dsDNA and low complement (OR = 2.3, 95% CI: 1.3-4.2, p < 0.01). Simultaneously positive anti-C1q, anti-dsDNA and low complement was strongly associated with renal involvement (OR = 14.9, 95% CI: 5.8-38.4, p < 0.01).
Anti-C1q was more common in patients with SLE and those of Asian race/ethnicity. We confirmed a significant association of anti-C1q with renal involvement, independent of demographics and other serologies. Anti-C1q in combination with anti-dsDNA and low complement was the strongest serological association with renal involvement. These data support the usefulness of anti-C1q in SLE, especially in lupus nephritis.
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Additional Links
http://dx.doi.org/10.1177/0961203314547791
http://lup.sagepub.com/content/early/2014/09/02/0961203314547791.full.pdf+html
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Archived with thanks to Lupus
ae974a485f413a2113503eed53cd6c53
10.1177/0961203314547791
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English Journal Articles (Peer Reviewed)

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