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Jonsson, Palmi V
von Bonsdorff, Mikaela B
Harris, Tamara B
van Buchem, Mark
Launer, Lenore J
MetadataShow full item record
CitationPediatrics 2014, 134 (4):761-70
AbstractThere are several lines of evidence pointing to fetal and other early origins of diseases of the aging brain, but there are no data directly addressing the hypotheses in an older population. We investigated the association of fetal size to late-age measures of brain structure and function in a large cohort of older men and women and explored the modifying effect of education on these associations.
Within the AGES (Age Gene/Environment Susceptibility)-Reykjavik population-based cohort (born between 1907 and 1935), archived birth records were abstracted for 1254 men and women who ∼75 years later underwent an examination that included brain MRI and extensive cognitive assessment.
Adjustment for intracranial volume, demographic and medical history characteristics, and lower Ponderal index at birth (per kg/m(3)), an indicator of third-trimester fetal wasting, was significantly associated with smaller volumes of total brain and white matter; βs (95% confidence intervals) were -1.0 (-1.9 to -0.0) and -0.5 (-1.0 to -0.0) mL. Furthermore, lower Ponderal index was associated with slower processing speed and reduced executive functioning but only in those with low education (β [95% confidence interval]: -0.136 [-0.235 to -0.036] and -0.077 [-0.153 to -0.001]).
This first study of its kind provides clinical measures suggesting that smaller birth size, as an indicator of a suboptimal intrauterine environment, is associated with late-life alterations in brain tissue volume and function. In addition, it shows that the effects of a suboptimal intrauterine environment on late-life cognitive function were present only in those with lower educational levels.
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RightsArchived with thanks to Pediatrics
- Late-life brain volume: a life-course approach. The AGES-Reykjavik study.
- Authors: Muller M, Sigurdsson S, Kjartansson O, Gunnarsdottir I, Thorsdottir I, Harris TB, van Buchem M, Gudnason V, Launer LJ, Age, Gene/Environment Susceptibility-Reykjavik Study Investigators.
- Issue date: 2016 May
- Salivary cortisol, brain volumes, and cognition in community-dwelling elderly without dementia.
- Authors: Geerlings MI, Sigurdsson S, Eiriksdottir G, Garcia ME, Harris TB, Gudnason V, Launer LJ
- Issue date: 2015 Sep 15
- Joint effect of mid- and late-life blood pressure on the brain: the AGES-Reykjavik study.
- Authors: Muller M, Sigurdsson S, Kjartansson O, Aspelund T, Lopez OL, Jonnson PV, Harris TB, van Buchem M, Gudnason V, Launer LJ, Age, Gene/Environment Susceptibility-Reykjavik Study Investigators.
- Issue date: 2014 Jun 17
- Persistence of the effect of birth size on dysglycaemia and type 2 diabetes in old age: AGES-Reykjavik Study.
- Authors: von Bonsdorff MB, Muller M, Aspelund T, Garcia M, Eiriksdottir G, Rantanen T, Gunnarsdottir I, Birgisdottir BE, Thorsdottir I, Sigurdsson G, Gudnason V, Launer L, Harris TB, Age, Gene/Environment Susceptibility-Reykjavik Study Investigators.
- Issue date: 2013 Aug
- Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study.
- Authors: Vidal JS, Sigurdsson S, Jonsdottir MK, Eiriksdottir G, Thorgeirsson G, Kjartansson O, Garcia ME, van Buchem MA, Harris TB, Gudnason V, Launer LJ
- Issue date: 2010 May