Melanocortin receptor agonist transiently increases oxygen consumption in rats
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Skarphedinsson, J O
Skuladottir, G V
Atlason, P T
Eiriksdottir, V H
Schiöth, H B
MetadataShow full item record
CitationNeuroreport. 2001, 12(17):3703-8
AbstractAcute injections of melanocortin (MC) agonist and antagonist are highly effective in reducing or increasing food take, respectively. Much less is known about how injection of MC receptor active substances affects metabolism, in particular during long term administration. Here we investigated the effect of 8 days continuous i.c.v. infusion of either MC receptor agonist MTII or the selective MC4 receptor antagonist HS024 on oxygen consumption, food intake and body weight in rats. We observed significant increase in oxygen consumption 2 days after the start of the MTII infusion. However, this increase had disappeared by day 4 of the study. No difference was observed in the oxygen consumption after injection of HS024. MTII substantially decreased the food intake during the first days, but then the feeding recovered and the body weight stabilised at a new level. The immediate effect of the MC receptor agonist on both food intake and metabolism was thus transient, even though the weight loss was maintained. The HS024 treated rats were hyperphagic throughout the test period, continuously gaining weight, resulting in increased fat pads and high leptin levels. This is the first study that describes long term effects of MC receptor agonist and antagonist on metabolism and energy balance.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats.
- Authors: Jonsson L, Skarphedinsson JO, Skuladottir GV, Watanobe H, Schiöth HB
- Issue date: 2002 Jun
- The role of the melanocortin system and the melanocortin-4 receptor in ring dove (Streptopelia risoria) feeding behavior.
- Authors: Strader AD, Schiöth HB, Buntin JD
- Issue date: 2003 Jan 17
- Effects of melanocortin receptor ligands on ethanol intake and opioid peptide levels in alcohol-preferring AA rats.
- Authors: Ploj K, Roman E, Kask A, Hyytiä P, Schiöth HB, Wikberg JE, Nylander I
- Issue date: 2002 Oct 30
- Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight.
- Authors: Grill HJ, Ginsberg AB, Seeley RJ, Kaplan JM
- Issue date: 1998 Dec 1
- Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II.
- Authors: Scarpace PJ, Matheny M, Zolotukhin S, Tümer N, Zhang Y
- Issue date: 2003 Aug