Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Hysi, Pirro GCheng, Ching-Yu
Springelkamp, Henriët
Macgregor, Stuart
Bailey, Jessica N Cooke
Wojciechowski, Robert
Vitart, Veronique
Nag, Abhishek
Hewitt, Alex W
Höhn, René
Venturini, Cristina
Mirshahi, Alireza
Ramdas, Wishal D
Thorleifsson, Gudmar
Vithana, Eranga
Khor, Chiea-Chuen
Stefansson, Arni B
Liao, Jiemin
Haines, Jonathan L
Amin, Najaf
Wang, Ya Xing
Wild, Philipp S
Ozel, Ayse B
Li, Jun Z
Fleck, Brian W
Zeller, Tanja
Staffieri, Sandra E
Teo, Yik-Ying
Cuellar-Partida, Gabriel
Luo, Xiaoyan
Allingham, R Rand
Richards, Julia E
Senft, Andrea
Karssen, Lennart C
Zheng, Yingfeng
Bellenguez, Céline
Xu, Liang
Iglesias, Adriana I
Wilson, James F
Kang, Jae H
van Leeuwen, Elisabeth M
Jonsson, Vesteinn
Thorsteinsdottir, Unnur
Despriet, Dominiek D G
Ennis, Sarah
Moroi, Sayoko E
Martin, Nicholas G
Jansonius, Nomdo M
Yazar, Seyhan
Tai, E-Shyong
Amouyel, Philippe
Kirwan, James
van Koolwijk, Leonieke M E
Hauser, Michael A
Jonasson, Fridbert
Leo, Paul
Loomis, Stephanie J
Fogarty, Rhys
Rivadeneira, Fernando
Kearns, Lisa
Lackner, Karl J
de Jong, Paulus T V M
Simpson, Claire L
Pennell, Craig E
Oostra, Ben A
Uitterlinden, André G
Saw, Seang-Mei
Lotery, Andrew J
Bailey-Wilson, Joan E
Hofman, Albert
Vingerling, Johannes R
Maubaret, Cécilia
Pfeiffer, Norbert
Wolfs, Roger C W
Lemij, Hans G
Young, Terri L
Pasquale, Louis R
Delcourt, Cécile
Spector, Timothy D
Klaver, Caroline C W
Small, Kerrin S
Burdon, Kathryn P
Stefansson, Kari
Wong, Tien-Yin
Viswanathan, Ananth
Mackey, David A
Craig, Jamie E
Wiggs, Janey L
van Duijn, Cornelia M
Hammond, Christopher J
Aung, Tin
Issue Date
2014-10
Metadata
Show full item recordCitation
Nat. Genet. 2014, 46 (10):1126-30Abstract
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10(-8) for rs6445055), two on chromosome 9 (P = 2.80 × 10(-11) for rs2472493 near ABCA1 and P = 6.39 × 10(-11) for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10(-11) for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG.Description
To access publisher's full text version of this article click on the hyperlink at the bottom of the pageAdditional Links
http://www.nature.com/ng/journal/v46/n10/pdf/ng.3087.pdfhttp://dx.doi.org/10.1038/ng.3087
Rights
Archived with thanks to Nature geneticsae974a485f413a2113503eed53cd6c53
10.1038/ng.3087
Scopus Count
Collections
Related articles
- Copy number variation at chromosome 5q21.2 is associated with intraocular pressure.
- Authors: Nag A, Venturini C, Hysi PG, Arno M, Aldecoa-Otalora Astarloa E, Macgregor S, Hewitt AW, Young TL, Mitchell P, Viswanathan AC, Mackey DA, Hammond CJ
- Issue date: 2013 May 1
- ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure.
- Authors: Springelkamp H, Iglesias AI, Cuellar-Partida G, Amin N, Burdon KP, van Leeuwen EM, Gharahkhani P, Mishra A, van der Lee SJ, Hewitt AW, Rivadeneira F, Viswanathan AC, Wolfs RC, Martin NG, Ramdas WD, van Koolwijk LM, Pennell CE, Vingerling JR, Mountain JE, Uitterlinden AG, Hofman A, Mitchell P, Lemij HG, Wang JJ, Klaver CC, Mackey DA, Craig JE, van Duijn CM, MacGregor S
- Issue date: 2015 May 1
- Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.
- Authors: Khawaja AP, Cooke Bailey JN, Wareham NJ, Scott RA, Simcoe M, Igo RP Jr, Song YE, Wojciechowski R, Cheng CY, Khaw PT, Pasquale LR, Haines JL, Foster PJ, Wiggs JL, Hammond CJ, Hysi PG, UK Biobank Eye and Vision Consortium., NEIGHBORHOOD Consortium.
- Issue date: 2018 Jun
- Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma.
- Authors: Chen Y, Lin Y, Vithana EN, Jia L, Zuo X, Wong TY, Chen LJ, Zhu X, Tam PO, Gong B, Qian S, Li Z, Liu X, Mani B, Luo Q, Guzman C, Leung CK, Li X, Cao W, Yang Q, Tham CC, Cheng Y, Zhang X, Wang N, Aung T, Khor CC, Pang CP, Sun X, Yang Z
- Issue date: 2014 Oct
- A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure.
- Authors: Choquet H, Thai KK, Yin J, Hoffmann TJ, Kvale MN, Banda Y, Schaefer C, Risch N, Nair KS, Melles R, Jorgenson E
- Issue date: 2017 Dec 13