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Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.

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Authors
Hysi, Pirro G
Cheng, Ching-Yu
Springelkamp, Henriët
Macgregor, Stuart
Bailey, Jessica N Cooke
Wojciechowski, Robert
Vitart, Veronique
Nag, Abhishek
Hewitt, Alex W
Höhn, René
Venturini, Cristina
Mirshahi, Alireza
Ramdas, Wishal D
Thorleifsson, Gudmar
Vithana, Eranga
Khor, Chiea-Chuen
Stefansson, Arni B
Liao, Jiemin
Haines, Jonathan L
Amin, Najaf
Wang, Ya Xing
Wild, Philipp S
Ozel, Ayse B
Li, Jun Z
Fleck, Brian W
Zeller, Tanja
Staffieri, Sandra E
Teo, Yik-Ying
Cuellar-Partida, Gabriel
Luo, Xiaoyan
Allingham, R Rand
Richards, Julia E
Senft, Andrea
Karssen, Lennart C
Zheng, Yingfeng
Bellenguez, Céline
Xu, Liang
Iglesias, Adriana I
Wilson, James F
Kang, Jae H
van Leeuwen, Elisabeth M
Jonsson, Vesteinn
Thorsteinsdottir, Unnur
Despriet, Dominiek D G
Ennis, Sarah
Moroi, Sayoko E
Martin, Nicholas G
Jansonius, Nomdo M
Yazar, Seyhan
Tai, E-Shyong
Amouyel, Philippe
Kirwan, James
van Koolwijk, Leonieke M E
Hauser, Michael A
Jonasson, Fridbert
Leo, Paul
Loomis, Stephanie J
Fogarty, Rhys
Rivadeneira, Fernando
Kearns, Lisa
Lackner, Karl J
de Jong, Paulus T V M
Simpson, Claire L
Pennell, Craig E
Oostra, Ben A
Uitterlinden, André G
Saw, Seang-Mei
Lotery, Andrew J
Bailey-Wilson, Joan E
Hofman, Albert
Vingerling, Johannes R
Maubaret, Cécilia
Pfeiffer, Norbert
Wolfs, Roger C W
Lemij, Hans G
Young, Terri L
Pasquale, Louis R
Delcourt, Cécile
Spector, Timothy D
Klaver, Caroline C W
Small, Kerrin S
Burdon, Kathryn P
Stefansson, Kari
Wong, Tien-Yin
Viswanathan, Ananth
Mackey, David A
Craig, Jamie E
Wiggs, Janey L
van Duijn, Cornelia M
Hammond, Christopher J
Aung, Tin
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Issue Date
2014-10

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Citation
Nat. Genet. 2014, 46 (10):1126-30
Abstract
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10(-8) for rs6445055), two on chromosome 9 (P = 2.80 × 10(-11) for rs2472493 near ABCA1 and P = 6.39 × 10(-11) for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10(-11) for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG.
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To access publisher's full text version of this article click on the hyperlink at the bottom of the page
Additional Links
http://www.nature.com/ng/journal/v46/n10/pdf/ng.3087.pdf
http://dx.doi.org/10.1038/ng.3087
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Archived with thanks to Nature genetics
ae974a485f413a2113503eed53cd6c53
10.1038/ng.3087
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