Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsArnardottir, Erna S
Nikonova, Elena V
Shockley, Keith R
Podtelezhnikov, Alexei A
Anafi, Ron C
Tanis, Keith Q
Stone, David J
Renger, John J
Winrow, Christopher J
Pack, Allan I
MetadataShow full item record
CitationSleep 2014, 37 (10):1589-600
AbstractTo address whether changes in gene expression in blood cells with sleep loss are different in individuals resistant and sensitive to sleep deprivation.
Blood draws every 4 h during a 3-day study: 24-h normal baseline, 38 h of continuous wakefulness and subsequent recovery sleep, for a total of 19 time-points per subject, with every 2-h psychomotor vigilance task (PVT) assessment when awake.
Fourteen subjects who were previously identified as behaviorally resistant (n = 7) or sensitive (n = 7) to sleep deprivation by PVT.
Thirty-eight hours of continuous wakefulness.
We found 4,481 unique genes with a significant 24-h diurnal rhythm during a normal sleep-wake cycle in blood (false discovery rate [FDR] < 5%). Biological pathways were enriched for biosynthetic processes during sleep. After accounting for circadian effects, two genes (SREBF1 and CPT1A, both involved in lipid metabolism) exhibited small, but significant, linear changes in expression with the duration of sleep deprivation (FDR < 5%). The main change with sleep deprivation was a reduction in the amplitude of the diurnal rhythm of expression of normally cycling probe sets. This reduction was noticeably higher in behaviorally resistant subjects than sensitive subjects, at any given P value. Furthermore, blood cell type enrichment analysis showed that the expression pattern difference between sensitive and resistant subjects is mainly found in cells of myeloid origin, such as monocytes.
Individual differences in behavioral effects of sleep deprivation are associated with differences in diurnal amplitude of gene expression for genes that show circadian rhythmicity.
DescriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the page
RightsArchived with thanks to Sleep
- Sustained attention performance during sleep deprivation associates with instability in behavior and physiologic measures at baseline.
- Authors: Chua EC, Yeo SC, Lee IT, Tan LC, Lau P, Cai S, Zhang X, Puvanendran K, Gooley JJ
- Issue date: 2014 Jan 1
- Mood, alertness, and performance in response to sleep deprivation and recovery sleep in experienced shiftworkers versus non-shiftworkers.
- Authors: Wehrens SM, Hampton SM, Kerkhofs M, Skene DJ
- Issue date: 2012 Jun
- The effect of split sleep schedules (6h-on/6h-off) on neurobehavioural performance, sleep and sleepiness.
- Authors: Short MA, Centofanti S, Hilditch C, Banks S, Lushington K, Dorrian J
- Issue date: 2016 May
- Trait-like vulnerability of higher-order cognition and ability to maintain wakefulness during combined sleep restriction and circadian misalignment.
- Authors: Sprecher KE, Ritchie HK, Burke TM, Depner CM, Smits AN, Dorrestein PC, Fleshner M, Knight R, Lowry CA, Turek FW, Vitaterna MH, Wright KP
- Issue date: 2019 Aug 1
- Classifying attentional vulnerability to total sleep deprivation using baseline features of Psychomotor Vigilance Test performance.
- Authors: Chua EC, Sullivan JP, Duffy JF, Klerman EB, Lockley SW, Kristal BS, Czeisler CA, Gooley JJ
- Issue date: 2019 Aug 20