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Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.

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Authors
Peterlongo, Paolo
Chang-Claude, Jenny
Moysich, Kirsten B
Rudolph, Anja
Schmutzler, Rita K
Simard, Jacques
Soucy, Penny
Eeles, Rosalind A
Easton, Douglas F
Hamann, Ute
Wilkening, Stefan
Feliubadalo, Lidia
Cybulski, Cezary
Gronwald, Jacek
Spurdle, Amanda B
Durda, Katarzyna
Jaworska-Bieniek, Katarzyna
Sukiennicki, Grzegorz
Rantala, Johanna
Arason, Adalgeir
Kaulich, Daphne Geschwantler
Giannini, Giuseppe
Chiquette, Jocelyne
Teixeira, Manuel R
Olswold, Curtis
Couch, Fergus J
Lindor, Noralane M
Wang, Xianshu
Walker, Logan C
Szabo, Csilla I
Offit, Kenneth
von Wachenfeldt, Anna
Papi, Laura
Ehrencrona, Hans
Corines, Marina
Barwell, Julian
Pfeiler, Georg
Tea, Muy-Kheng M
Phelan, Catherine M
Greene, Mark H
Mai, Phuong L
Rennert, Gad
Mulligan, Anna Marie
Martayan, Aline
Glendon, Gord
Tchatchou, Sandrine
Maia, Ana-Teresa
Walker, Lisa
Montagna, Marco
Andrulis, Irene L
Niederacher, Dieter
Askmalm, Marie Stenmark
Borg, Åke
Kuchenbaecker, Karoline B
Tibiletti, Maria Grazia
McGuffog, Lesley
Barrowdale, Daniel
Healey, Sue
Lee, Andrew
Izatt, Louise
Pharoah, Paul D P
Chenevix-Trench, Georgia
Antoniou, Antonis C
Steinemann, Doris
Matricardi, Laura
Radice, Paolo
Friedman, Eitan
Lubinski, Jan
Jakubowska, Anna
Gómez Garcia, Encarna B
Olopade, Olufunmilayo I
Side, Lucy E
Nussbaum, Robert L
Nathanson, Katherine L
Domchek, Susan M
Rebbeck, Timothy R
Vratimos, Athanassios
Plendl, Hansjoerg
Arun, Banu K
Karlan, Beth Y
Orsulic, Sandra
Lester, Jenny
Chung, Wendy K
Kennedy, M John
Miron, Alex
Southey, Melissa C
Goldgar, David E
Fostira, Florentia
Buys, Saundra S
Janavicius, Ramunas
Kast, Karin
Dorfling, Cecilia M
van Rensburg, Elizabeth J
Ding, Yuan Chun
Neuhausen, Susan L
Rogers, Mark T
Hansen, Thomas V O
Gerdes, Anne-Marie
Arnold, Norbert
Ejlertsen, Bent
Jønson, Lars
Osorio, Ana
Martínez-Bouzas, Cristina
Rhiem, Kerstin
Benitez, Javier
Conway, Edye E
Blazer, Kathleen R
Porteous, Mary E
Weitzel, Jeffrey N
Garber, Judy E
Manoukian, Siranoush
Peissel, Bernard
Zaffaroni, Daniela
Scuvera, Giulietta
Barile, Monica
Ficarazzi, Filomena
Ditsch, Nina
Mariette, Frederique
Fortuzzi, Stefano
Morrison, Patrick J
Platte, Radka
Viel, Alessandra
Jacobs, Lauren
Donaldson, Alan
Brewer, Carole
Foo, Claire
Evans, D Gareth R
Frost, Debra
Eccles, Diana
Brady, Angela
Cook, Jackie
Tischkowitz, Marc
Varon-Mateeva, Raymonda
Robson, Mark E
Wappenschmidt, Barbara
Adlard, Julian
Toland, Amanda Ewart
Davidson, Rosemarie
Hodgson, Shirley V
Ellis, Steve
Cole, Trevor
Godwin, Andrew K
Claes, Kathleen
Van Maerken, Tom
Zhang, Liying
Meindl, Alfons
Gehrig, Andrea
Sutter, Christian
Bojesen, Anders
Wang-Gohrke, Shan
Engel, Christoph
Chen, Bowang
Bressac-de Paillerets, Brigitte
Buecher, Bruno
Delnatte, Capucine
Joseph, Vijai
Houdayer, Claude
Stoppa-Lyonnet, Dominique
Damiola, Francesca
Coupier, Isabelle
Pedersen, Inge Sokilde
Barjhoux, Laure
Venat-Bouvet, Laurence
Golmard, Lisa
Rookus, Matti A
Boutry-Kryza, Nadia
Berger, Andreas
Sinilnikova, Olga M
Caron, Olivier
Pujol, Pascal
Mazoyer, Sylvie
Belotti, Muriel
Thomassen, Mads
Piedmonte, Marion
Friedlander, Michael L
Rodriguez, Gustavo C
Copeland, Larry J
Singer, Christian F
Schmidt, Marjanka K
de la Hoya, Miguel
Segura, Pedro Perez
Nevanlinna, Heli
Aittomäki, Kristiina
van Os, Theo A M
Jensen, Uffe Birk
Meijers-Heijboer, Hanne E J
van der Hout, Annemarie H
Vreeswijk, Maaike P G
Rappaport, Christine
Hoogerbrugge, Nicoline
Ausems, Margreet G E M
van der Baan, Frederieke H
van Doorn, Helena C
Collée, J Margriet
Olah, Edith
Diez, Orland
Laitman, Yael
Blanco, Ignacio
Lazaro, Conxi
Lose, Felicity
Brunet, Joan
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Issue Date
2015-01

Metadata
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Citation
Cancer Epidemiol. Biomarkers Prev. 2015, 24 (1):308-16
Abstract
BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes.
Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach.
The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments.
There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.
Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies. Cancer Epidemiol Biomarkers Prev; 24(1); 308-16. ©2014 AACR.
Description
To access publisher's full text version of this article click on the hyperlink at the bottom of the page
Additional Links
http://dx.doi.org/ 10.1158/1055-9965.EPI-14-0532
http://cebp.aacrjournals.org/content/24/1/308.full.pdf
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294951/
Rights
Archived with thanks to Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ae974a485f413a2113503eed53cd6c53
10.1158/1055-9965.EPI-14-0532
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