• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

Age-Related Macular Degeneration and Mortality in Community-Dwelling Elders: The Age, Gene/Environment Susceptibility Reykjavik Study.

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Thumbnail
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Fisher, Diana E
Jonasson, Fridbert
Eiriksdottir, Gudny
Sigurdsson, Sigurdur
Klein, Ronald
Launer, Lenore J
Gudnason, Vilmundur
Cotch, Mary Frances
Issue Date
2014-09-25

Metadata
Show full item record
Citation
Ophthalmology 2015,122(2):382-90
Abstract
To investigate the association between age-related macular degeneration (AMD) and mortality in older persons.
Population-based prospective cohort study.
Participants 67 to 96 years of age (43.1% male) enrolled between 2002 and 2006 in the Age, Gene/Environment Susceptibility-Reykjavik Study.
Retinal photographs of the macula were acquired digitally and evaluated for the presence of AMID lesions using the Wisconsin Age-Related Maculopathy grading scheme. Mortality was assessed prospectively through 2013 with cause of death available through 2009. The association between AMD and death, resulting from any cause and specifically cardiovascular disease (CVD), was examined using Cox proportional hazards regression with age as the time scale, adjusted for significant risk factors and comorbid conditions. To address a violation in the proportional hazards assumption, analyses were stratified into 2 groups based on the mean age at death (83 years).
Mortality resulting from all causes and CVD.
Among 4910 participants, after a median follow-up of 8.6 years, 1742 died (35.5%), of whom 614 (35.2%) had signs of AMD at baseline. Cardiovascular disease was the cause of death for 357 people who died before the end of 2009, of whom 144 (40%) had AMD (101 with early disease and 43 with late disease). After considering covariates, including comorbid conditions, having early AMD at any age or having late AMD in individuals younger than 83 years (n = 4179) were not associated with all-cause or CVD mortality. In individuals 83 years of age and older (n = 731), late AMD was associated significantly with increased risk of all-cause mortality (hazard ratio [HR], 1.76; 95% confidence interval [CI], 1.20-2.57) and CVD-related mortality (HR, 2.37; 95% CI, 1.41-3.98). In addition to having AMD, older individuals who died were more likely to be male and to have low body mass index, impaired cognition, and microalbuminuria.
Competing risk factors and concomitant conditions are important in determining mortality risk resulting from AMD. Individuals with early AMD are not more likely to die than peers of comparable age. Late AMD becomes a predictor of mortality by the mid-octogenarian years.
Description
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field
Additional Links
http://dx.doi.org/10.1016/j.ophtha.2014.08.006
Rights
Archived with thanks to Ophthalmology
ae974a485f413a2113503eed53cd6c53
10.1016/j.ophtha.2014.08.006
Scopus Count
Collections
English Journal Articles (Peer Reviewed)

entitlement

Related articles

  • Association of Age-Related Macular Degeneration With Risk of All-Cause and Specific-Cause Mortality in the National Health and Nutrition Examination Survey, 2005 to 2008.
  • Authors: Zhu Z, Wang W, Keel S, Zhang J, He M
  • Issue date: 2019 Mar 1
  • Age-related macular degeneration and mortality in older women: the study of osteoporotic fractures.
  • Authors: Pedula KL, Coleman AL, Yu F, Cauley JA, Ensrud KE, Hochberg MC, Fink HA, Hillier TA, Study of Osteoporotic Fractures Research Group.
  • Issue date: 2015 May
  • Serum carboxymethyllysine, an advanced glycation end product, and age-related macular degeneration: the Age, Gene/Environment Susceptibility-Reykjavik Study.
  • Authors: Semba RD, Cotch MF, Gudnason V, Eiríksdottir G, Harris TB, Sun K, Klein R, Jonasson F, Ferrucci L, Schaumberg DA
  • Issue date: 2014 Apr 1
  • Association of Mortality with Ocular Diseases and Visual Impairment in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 Report Number 13.
  • Authors: Age-Related Eye Disease Study 2 Research Group., Papudesu C, Clemons TE, Agrón E, Chew EY
  • Issue date: 2018 Apr
  • Age-related macular degeneration and risk of coronary heart disease: the Atherosclerosis Risk in Communities Study.
  • Authors: Wong TY, Tikellis G, Sun C, Klein R, Couper DJ, Sharrett AR
  • Issue date: 2007 Jan

DSpace software (copyright © 2002 - 2022)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.