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dc.contributor.authorHaflidadottir, Svanhildur
dc.contributor.authorJonasson, Jon G
dc.contributor.authorNorland, Helga
dc.contributor.authorEinarsdottir, Sylvia O
dc.contributor.authorKleiner, David E
dc.contributor.authorLund, Sigrun H
dc.contributor.authorBjörnsson, Einar S
dc.date.accessioned2015-01-20T09:48:50Zen
dc.date.available2015-01-20T09:48:50Zen
dc.date.issued2014en
dc.date.submitted2015en
dc.identifier.citationBMC Gastroenterol. 2014, 14:166en
dc.identifier.issn1471-230Xen
dc.identifier.pmid25260964en
dc.identifier.doi10.1186/1471-230X-14-166en
dc.identifier.urihttp://hdl.handle.net/2336/338573en
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.en
dc.description.abstractFew studies have compared the prognosis and liver-related mortality in patients with NAFLD (nonalcoholic fatty liver disease) and AFLD (alcoholic fatty liver disease). We aimed to investigate the etiology and liver-related mortality of patients with liver biopsy verified fatty liver disease in a population based setting.
dc.description.abstractIn this retrospective study, all patients who underwent a liver biopsy 1984-2009 at the National University Hospital of Iceland were identified through a computerized pathological database with the code for fatty liver. Only patients with NAFLD and AFLD were included and medical records reviewed. The patients were linked to the Hospital Discharge Register, the Causes of Death Registry and Centre for Addiction Medicine.
dc.description.abstractA total of 151 had NAFLD and 94 AFLD with median survival of 24 years and 20 years, respectively (p = NS). A total of 10/151 (7%) patients developed cirrhosis in the NAFLD group and 19/94 (20%) in AFLD group (p = 0.03). The most common cause of death in the NAFLD group was cardiovascular disease (48%). Liver disease was the most common cause of death in the AFLD group (36%), whereas liver-related death occurred in 7% of the NAFLD group. The mean liver-related death rate among the general population during the study period was 0.1% of all deaths. There was a significantly worse survival for patients in the AFLD group compared to the NAFLD group after adjusting for gender, calendar year of diagnosis and age at diagnosis (HR 2.16, p = 0.009). The survival for patients with moderate to severe fibrosis was significantly worse than for patients with mild fibrosis after adjusting for gender, calendar year of diagnosis and age at diagnosis (HR 2.09, p = 0.01).
dc.description.abstractPatients with fatty liver disease showed a markedly higher risk of developing liver-related death compared to the general population. The AFLD group had higher liver-related mortality and had a worse survival than the NAFLD group. Patients with more severe fibrosis at baseline showed a worse survival than patients with none or mild fibrosis at baseline.
dc.description.sponsorshipNIH, National Cancer Institute University Hospital of Iceland Research Funden
dc.language.isoenen
dc.publisherBioMed Central Ltden
dc.relation.urlhttp://dx.doi.org/10.1186/1471-230X-14-166en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182763/en
dc.rightsopenAccessen
dc.subjectLifrarbólgaen
dc.subjectFitulifuren
dc.subjectDánarmeinen
dc.subject.lcshLiver Cirrhosis/etiologyen
dc.subject.meshFatty Liver, Alcoholic/complicationsen
dc.subject.meshFatty Liver, Alcoholic/mortality*en
dc.subject.meshCause of Deathen
dc.subject.meshRisk Factorsen
dc.subject.meshFatty Liveren
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshDisease Progressionen
dc.subject.meshFatty Liver, Alcoholic/pathologyen
dc.subject.meshFemaleen
dc.subject.meshFollow-Up Studiesen
dc.subject.meshHumansen
dc.subject.meshLiver Cirrhosis/mortalityen
dc.subject.meshLiver Cirrhosis/pathologyen
dc.subject.meshLiver Cirrhosis, Alcoholic/etiologyen
dc.subject.meshLiver Cirrhosis, Alcoholic/mortality*en
dc.subject.meshLiver Cirrhosis, Alcoholic/pathologyen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshNon-alcoholic Fatty Liver Disease/complicationsen
dc.subject.meshNon-alcoholic Fatty Liver Disease/mortality*en
dc.subject.meshNon-alcoholic Fatty Liver Disease/pathologyen
dc.subject.meshPrognosisen
dc.subject.meshRetrospective Studiesen
dc.titleLong-term follow-up and liver-related death rate in patients with non-alcoholic and alcoholic related fatty liver disease.en
dc.typeArticleen
dc.identifier.journalBMC gastroenterologyen
dc.rights.accessOpen Accessen
refterms.dateFOA2018-09-12T14:00:49Z
html.description.abstractFew studies have compared the prognosis and liver-related mortality in patients with NAFLD (nonalcoholic fatty liver disease) and AFLD (alcoholic fatty liver disease). We aimed to investigate the etiology and liver-related mortality of patients with liver biopsy verified fatty liver disease in a population based setting.
html.description.abstractIn this retrospective study, all patients who underwent a liver biopsy 1984-2009 at the National University Hospital of Iceland were identified through a computerized pathological database with the code for fatty liver. Only patients with NAFLD and AFLD were included and medical records reviewed. The patients were linked to the Hospital Discharge Register, the Causes of Death Registry and Centre for Addiction Medicine.
html.description.abstractA total of 151 had NAFLD and 94 AFLD with median survival of 24 years and 20 years, respectively (p = NS). A total of 10/151 (7%) patients developed cirrhosis in the NAFLD group and 19/94 (20%) in AFLD group (p = 0.03). The most common cause of death in the NAFLD group was cardiovascular disease (48%). Liver disease was the most common cause of death in the AFLD group (36%), whereas liver-related death occurred in 7% of the NAFLD group. The mean liver-related death rate among the general population during the study period was 0.1% of all deaths. There was a significantly worse survival for patients in the AFLD group compared to the NAFLD group after adjusting for gender, calendar year of diagnosis and age at diagnosis (HR 2.16, p = 0.009). The survival for patients with moderate to severe fibrosis was significantly worse than for patients with mild fibrosis after adjusting for gender, calendar year of diagnosis and age at diagnosis (HR 2.09, p = 0.01).
html.description.abstractPatients with fatty liver disease showed a markedly higher risk of developing liver-related death compared to the general population. The AFLD group had higher liver-related mortality and had a worse survival than the NAFLD group. Patients with more severe fibrosis at baseline showed a worse survival than patients with none or mild fibrosis at baseline.


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